Use of a trigger tool to detect adverse drug reactions in an emergency department
Abstract Background Although there are systems for reporting adverse drug reactions (ADR), these safety events remain under reported. The low-cost, low-tech trigger tool method is based on the detection of events through clues, and it seems to increase the detection of adverse events compared to tra...
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| Format: | Article |
| Language: | English |
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BMC
2017-11-01
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| Series: | BMC Pharmacology and Toxicology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40360-017-0177-y |
| _version_ | 1818237101058031616 |
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| author | Silvana Maria de Almeida Aruana Romualdo Andressa de Abreu Ferraresi Giovana Roberta Zelezoglo Alexandre R. Marra Michael B. Edmond |
| author_facet | Silvana Maria de Almeida Aruana Romualdo Andressa de Abreu Ferraresi Giovana Roberta Zelezoglo Alexandre R. Marra Michael B. Edmond |
| author_sort | Silvana Maria de Almeida |
| collection | DOAJ |
| description | Abstract Background Although there are systems for reporting adverse drug reactions (ADR), these safety events remain under reported. The low-cost, low-tech trigger tool method is based on the detection of events through clues, and it seems to increase the detection of adverse events compared to traditional methodologies. This study seeks to estimate the prevalence of adverse reactions to drugs in patients seeking care in the emergency department. Methods Retrospective study from January to December, 2014, applying the Institute for Healthcare Improvement (IHI) trigger tool methodology for patients treated at the emergency room of a tertiary care hospital. Results The estimated prevalence of adverse reactions in patients presenting to the emergency department was 2.3% [CI95 1.3% to 3.3%]; 28.6% of cases required hospitalization at an average cost of US$ 5698.44. The most common triggers were hydrocortisone (57% of the cases), diphenhydramine (14%) and fexofenadine (14%). Anti-infectives (19%), cardiovascular agents (14%), and musculoskeletal drugs (14%) were the most common causes of adverse reactions. According to the Naranjo Scale, 71% were classified as possible and 29% as probable. There was no association between adverse reactions and age and sex in the present study. Conclusions The use of the trigger tool to identify adverse reactions in the emergency department was possible to identify a prevalence of 2.3%. It showed to be a viable method that can provide a better understanding of adverse drug reactions in this patient population. |
| first_indexed | 2024-12-12T12:20:24Z |
| format | Article |
| id | doaj.art-4f451ef5e71c4d829ffad03f4e72ed7e |
| institution | Directory Open Access Journal |
| issn | 2050-6511 |
| language | English |
| last_indexed | 2024-12-12T12:20:24Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pharmacology and Toxicology |
| spelling | doaj.art-4f451ef5e71c4d829ffad03f4e72ed7e2022-12-22T00:24:41ZengBMCBMC Pharmacology and Toxicology2050-65112017-11-011811710.1186/s40360-017-0177-yUse of a trigger tool to detect adverse drug reactions in an emergency departmentSilvana Maria de Almeida0Aruana Romualdo1Andressa de Abreu Ferraresi2Giovana Roberta Zelezoglo3Alexandre R. Marra4Michael B. Edmond5Pharmacist, Hospital Israelita Albert EinsteinPharmacist, Hospital Israelita Albert EinsteinPharmacist, Hospital Israelita Albert EinsteinPharmacist, Hospital Israelita Albert EinsteinDivision of Medical Practice, Hospital Israelita Albert EinsteinOffice of Clinical Quality, Safety and Performance Improvement, University of Iowa Hospitals and ClinicsAbstract Background Although there are systems for reporting adverse drug reactions (ADR), these safety events remain under reported. The low-cost, low-tech trigger tool method is based on the detection of events through clues, and it seems to increase the detection of adverse events compared to traditional methodologies. This study seeks to estimate the prevalence of adverse reactions to drugs in patients seeking care in the emergency department. Methods Retrospective study from January to December, 2014, applying the Institute for Healthcare Improvement (IHI) trigger tool methodology for patients treated at the emergency room of a tertiary care hospital. Results The estimated prevalence of adverse reactions in patients presenting to the emergency department was 2.3% [CI95 1.3% to 3.3%]; 28.6% of cases required hospitalization at an average cost of US$ 5698.44. The most common triggers were hydrocortisone (57% of the cases), diphenhydramine (14%) and fexofenadine (14%). Anti-infectives (19%), cardiovascular agents (14%), and musculoskeletal drugs (14%) were the most common causes of adverse reactions. According to the Naranjo Scale, 71% were classified as possible and 29% as probable. There was no association between adverse reactions and age and sex in the present study. Conclusions The use of the trigger tool to identify adverse reactions in the emergency department was possible to identify a prevalence of 2.3%. It showed to be a viable method that can provide a better understanding of adverse drug reactions in this patient population.http://link.springer.com/article/10.1186/s40360-017-0177-yTrigger toolPharmacovigilanceAdverse drug reactionsMedicationHospitalMethodology |
| spellingShingle | Silvana Maria de Almeida Aruana Romualdo Andressa de Abreu Ferraresi Giovana Roberta Zelezoglo Alexandre R. Marra Michael B. Edmond Use of a trigger tool to detect adverse drug reactions in an emergency department BMC Pharmacology and Toxicology Trigger tool Pharmacovigilance Adverse drug reactions Medication Hospital Methodology |
| title | Use of a trigger tool to detect adverse drug reactions in an emergency department |
| title_full | Use of a trigger tool to detect adverse drug reactions in an emergency department |
| title_fullStr | Use of a trigger tool to detect adverse drug reactions in an emergency department |
| title_full_unstemmed | Use of a trigger tool to detect adverse drug reactions in an emergency department |
| title_short | Use of a trigger tool to detect adverse drug reactions in an emergency department |
| title_sort | use of a trigger tool to detect adverse drug reactions in an emergency department |
| topic | Trigger tool Pharmacovigilance Adverse drug reactions Medication Hospital Methodology |
| url | http://link.springer.com/article/10.1186/s40360-017-0177-y |
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