A case of type 2 diabetes mellitus with weight gain and worsening of glycemic management after tezepelumab administration for severe bronchial asthma
Abstract Some cases of bronchial asthma are refractory to conventional therapies. As the pathogenesis of bronchial asthma has been clarified, new treatments, such as bronchial thermoplasty and biological drugs, have been developed. Tezepelumab, an anti‐thymic stromal lymphopoietin antibody, has been...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-03-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.14127 |
| _version_ | 1797289255744045056 |
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| author | Kotaro Umamoto Ryotaro Bouchi Noriko Ihana‐Sugiyama Noriko Kodani Mitsuru Ohsugi Masayuki Hojo Kohjiro Ueki Hiroshi Kajio |
| author_facet | Kotaro Umamoto Ryotaro Bouchi Noriko Ihana‐Sugiyama Noriko Kodani Mitsuru Ohsugi Masayuki Hojo Kohjiro Ueki Hiroshi Kajio |
| author_sort | Kotaro Umamoto |
| collection | DOAJ |
| description | Abstract Some cases of bronchial asthma are refractory to conventional therapies. As the pathogenesis of bronchial asthma has been clarified, new treatments, such as bronchial thermoplasty and biological drugs, have been developed. Tezepelumab, an anti‐thymic stromal lymphopoietin antibody, has been reported to inhibit the exacerbation of severe asthma; however, its adverse effects on glucose metabolism have not yet been reported. We encountered a case of weight gain and worsening glycemic management in a patient with type 2 diabetes and refractory bronchial asthma after the initiation of tezepelumab treatment. It has been reported that the overexpression of thymic stromal lymphopoietin in mice resulted in an enhanced release of free fatty acids from adipose tissues and the liver; thus, the administration of anti‐thymic stromal lymphopoietin antibodies in the present case might have caused obesity, fatty liver and lower glucose tolerance. |
| first_indexed | 2024-03-07T19:02:17Z |
| format | Article |
| id | doaj.art-4f45e155bdc74c508b92986572c95912 |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-03-07T19:02:17Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-4f45e155bdc74c508b92986572c959122024-03-01T12:52:02ZengWileyJournal of Diabetes Investigation2040-11162040-11242024-03-0115338839010.1111/jdi.14127A case of type 2 diabetes mellitus with weight gain and worsening of glycemic management after tezepelumab administration for severe bronchial asthmaKotaro Umamoto0Ryotaro Bouchi1Noriko Ihana‐Sugiyama2Noriko Kodani3Mitsuru Ohsugi4Masayuki Hojo5Kohjiro Ueki6Hiroshi Kajio7Department of Diabetes, Endocrinology and Metabolism, Center Hospital National Center for Global Health and Medicine Tokyo JapanDepartment of Diabetes, Endocrinology and Metabolism, Center Hospital National Center for Global Health and Medicine Tokyo JapanDepartment of Diabetes, Endocrinology and Metabolism, Center Hospital National Center for Global Health and Medicine Tokyo JapanDepartment of Diabetes, Endocrinology and Metabolism, Center Hospital National Center for Global Health and Medicine Tokyo JapanDepartment of Diabetes, Endocrinology and Metabolism, Center Hospital National Center for Global Health and Medicine Tokyo JapanDepartment of Respiratory Medicine, Center Hospital National Center for Global Health and Medicine Tokyo JapanDepartment of Diabetes, Endocrinology and Metabolism, Center Hospital National Center for Global Health and Medicine Tokyo JapanDepartment of Diabetes, Endocrinology and Metabolism, Center Hospital National Center for Global Health and Medicine Tokyo JapanAbstract Some cases of bronchial asthma are refractory to conventional therapies. As the pathogenesis of bronchial asthma has been clarified, new treatments, such as bronchial thermoplasty and biological drugs, have been developed. Tezepelumab, an anti‐thymic stromal lymphopoietin antibody, has been reported to inhibit the exacerbation of severe asthma; however, its adverse effects on glucose metabolism have not yet been reported. We encountered a case of weight gain and worsening glycemic management in a patient with type 2 diabetes and refractory bronchial asthma after the initiation of tezepelumab treatment. It has been reported that the overexpression of thymic stromal lymphopoietin in mice resulted in an enhanced release of free fatty acids from adipose tissues and the liver; thus, the administration of anti‐thymic stromal lymphopoietin antibodies in the present case might have caused obesity, fatty liver and lower glucose tolerance.https://doi.org/10.1111/jdi.14127AsthmaObesityTezepelumab |
| spellingShingle | Kotaro Umamoto Ryotaro Bouchi Noriko Ihana‐Sugiyama Noriko Kodani Mitsuru Ohsugi Masayuki Hojo Kohjiro Ueki Hiroshi Kajio A case of type 2 diabetes mellitus with weight gain and worsening of glycemic management after tezepelumab administration for severe bronchial asthma Journal of Diabetes Investigation Asthma Obesity Tezepelumab |
| title | A case of type 2 diabetes mellitus with weight gain and worsening of glycemic management after tezepelumab administration for severe bronchial asthma |
| title_full | A case of type 2 diabetes mellitus with weight gain and worsening of glycemic management after tezepelumab administration for severe bronchial asthma |
| title_fullStr | A case of type 2 diabetes mellitus with weight gain and worsening of glycemic management after tezepelumab administration for severe bronchial asthma |
| title_full_unstemmed | A case of type 2 diabetes mellitus with weight gain and worsening of glycemic management after tezepelumab administration for severe bronchial asthma |
| title_short | A case of type 2 diabetes mellitus with weight gain and worsening of glycemic management after tezepelumab administration for severe bronchial asthma |
| title_sort | case of type 2 diabetes mellitus with weight gain and worsening of glycemic management after tezepelumab administration for severe bronchial asthma |
| topic | Asthma Obesity Tezepelumab |
| url | https://doi.org/10.1111/jdi.14127 |
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