Normal human microbiota and dysbiosis: Implications for health and disease
The normal human microbiota, formerly called the "microbial flora," consists of bacteria, fungi, viruses, and parasites that colonise the skin and mucous membranes of the respiratory, gastrointestinal, and genitourinary tracts. The number and diversity of microorganisms varies between diff...
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| Format: | Article |
| Language: | srp |
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Pharmaceutical Association of Serbia, Belgrade, Serbia
2024-01-01
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| Series: | Arhiv za farmaciju |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2024/0004-19632401001B.pdf |
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| author | Božić Dragana D. Milenković Marina Antić-Stanković Jelena Arsenović-Ranin Nevena Bufan Biljana |
| author_facet | Božić Dragana D. Milenković Marina Antić-Stanković Jelena Arsenović-Ranin Nevena Bufan Biljana |
| author_sort | Božić Dragana D. |
| collection | DOAJ |
| description | The normal human microbiota, formerly called the "microbial flora," consists of bacteria, fungi, viruses, and parasites that colonise the skin and mucous membranes of the respiratory, gastrointestinal, and genitourinary tracts. The number and diversity of microorganisms varies between different body niches and is greatest in the intestinal tract. The microbiota contributes to the homeostasis of the human organism by preventing colonisation by pathogenic microorganisms, participating in digestive processes and metabolism, and regulating immune functions. Various environmental and genetic factors can lead to an imbalance in the human microbiota, called dysbiosis, which can affect human health. Dysbiosis is usually the result of decreased microbial diversity and a lower number of saprophytic microorganisms, followed by an overgrowth of opportunistic species. The most common diseases directly related to intestinal dysbiosis are antibiotic-associated diarrhoea and pseudomembranous colitis, both of which are associated with the excessive growth of harmful bacteria and Clostridioides difficile following broad-spectrum antibiotic therapy. Dysbiosis is associated with various health conditions or diseases such as acne, psoriasis, eczema, chronic obstructive pulmonary disease, inflammatory bowel disease, obesity, metabolic syndrome, type 2 diabetes, autoimmune diseases and allergies, neurological diseases such as Parkinson's disease, Alzheimer's disease, epilepsy and stroke, depression, anxiety, infertility, preterm birth, and malignancies. |
| first_indexed | 2024-04-24T13:41:40Z |
| format | Article |
| id | doaj.art-4f48098d8fd84420b26ba199cc024480 |
| institution | Directory Open Access Journal |
| issn | 0004-1963 2217-8767 |
| language | srp |
| last_indexed | 2024-04-24T13:41:40Z |
| publishDate | 2024-01-01 |
| publisher | Pharmaceutical Association of Serbia, Belgrade, Serbia |
| record_format | Article |
| series | Arhiv za farmaciju |
| spelling | doaj.art-4f48098d8fd84420b26ba199cc0244802024-04-04T08:11:07ZsrpPharmaceutical Association of Serbia, Belgrade, SerbiaArhiv za farmaciju0004-19632217-87672024-01-0174112210.5937/arhfarm74-466120004-19632401001BNormal human microbiota and dysbiosis: Implications for health and diseaseBožić Dragana D.0https://orcid.org/0000-0002-5373-5540Milenković Marina1https://orcid.org/0000-0002-6298-0599Antić-Stanković Jelena2https://orcid.org/0000-0002-0348-4368Arsenović-Ranin Nevena3https://orcid.org/0000-0002-8052-8969Bufan Biljana4https://orcid.org/0000-0003-1861-5700University of Belgrade, Faculty of Pharmacy, Department of Microbiology and Immunology, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Microbiology and Immunology, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Microbiology and Immunology, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Microbiology and Immunology, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Microbiology and Immunology, SerbiaThe normal human microbiota, formerly called the "microbial flora," consists of bacteria, fungi, viruses, and parasites that colonise the skin and mucous membranes of the respiratory, gastrointestinal, and genitourinary tracts. The number and diversity of microorganisms varies between different body niches and is greatest in the intestinal tract. The microbiota contributes to the homeostasis of the human organism by preventing colonisation by pathogenic microorganisms, participating in digestive processes and metabolism, and regulating immune functions. Various environmental and genetic factors can lead to an imbalance in the human microbiota, called dysbiosis, which can affect human health. Dysbiosis is usually the result of decreased microbial diversity and a lower number of saprophytic microorganisms, followed by an overgrowth of opportunistic species. The most common diseases directly related to intestinal dysbiosis are antibiotic-associated diarrhoea and pseudomembranous colitis, both of which are associated with the excessive growth of harmful bacteria and Clostridioides difficile following broad-spectrum antibiotic therapy. Dysbiosis is associated with various health conditions or diseases such as acne, psoriasis, eczema, chronic obstructive pulmonary disease, inflammatory bowel disease, obesity, metabolic syndrome, type 2 diabetes, autoimmune diseases and allergies, neurological diseases such as Parkinson's disease, Alzheimer's disease, epilepsy and stroke, depression, anxiety, infertility, preterm birth, and malignancies.https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2024/0004-19632401001B.pdfhuman microbiotadysbiosiscommensal bacteriadysbiosis-associated diseases |
| spellingShingle | Božić Dragana D. Milenković Marina Antić-Stanković Jelena Arsenović-Ranin Nevena Bufan Biljana Normal human microbiota and dysbiosis: Implications for health and disease Arhiv za farmaciju human microbiota dysbiosis commensal bacteria dysbiosis-associated diseases |
| title | Normal human microbiota and dysbiosis: Implications for health and disease |
| title_full | Normal human microbiota and dysbiosis: Implications for health and disease |
| title_fullStr | Normal human microbiota and dysbiosis: Implications for health and disease |
| title_full_unstemmed | Normal human microbiota and dysbiosis: Implications for health and disease |
| title_short | Normal human microbiota and dysbiosis: Implications for health and disease |
| title_sort | normal human microbiota and dysbiosis implications for health and disease |
| topic | human microbiota dysbiosis commensal bacteria dysbiosis-associated diseases |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2024/0004-19632401001B.pdf |
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