Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults
Abstract We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as were selected polymorphisms of the cor...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-67516-2 |
| _version_ | 1818994645153087488 |
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| author | Anna Sokołowska Anna S. Świerzko Gabriela Gajek Aleksandra Gołos Mateusz Michalski Mateusz Nowicki Agnieszka Szala-Poździej Anna Wolska-Washer Olga Brzezińska Agnieszka Wierzbowska Krzysztof Jamroziak Marek L. Kowalski Steffen Thiel Misao Matsushita Jens C. Jensenius Maciej Cedzyński |
| author_facet | Anna Sokołowska Anna S. Świerzko Gabriela Gajek Aleksandra Gołos Mateusz Michalski Mateusz Nowicki Agnieszka Szala-Poździej Anna Wolska-Washer Olga Brzezińska Agnieszka Wierzbowska Krzysztof Jamroziak Marek L. Kowalski Steffen Thiel Misao Matsushita Jens C. Jensenius Maciej Cedzyński |
| author_sort | Anna Sokołowska |
| collection | DOAJ |
| description | Abstract We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as were selected polymorphisms of the corresponding genes (FCN1, FCN2, FCN3 and MBL2). The control group (C) consisted of 267 healthy unrelated individuals. Median level of ficolin-1 in patients was lower (p < 0.000001) while median levels of ficolin-2, ficolin-3 and MBL were higher (p < 0.000001, p < 0.000001 and p = 0.0016, respectively) compared with controls. These findings were generally associated with AML itself, however the highest MBL levels predicted higher risk of severe hospital infections (accompanied with bacteremia and/or fungaemia) (p = 0.012) while the lowest ficolin-1 concentrations tended to be associated with prolonged (> 7 days) fever (p = 0.026). Genotyping indicated an association of G/G homozygosity (corresponding to FCN1 gene − 542 G > A polymorphism) with malignancy [p = 0.004, OR = 2.95, 95% CI (1.41–6.16)]. Based on ROC analysis, ficolin-1, -2 and -3 may be considered candidate supplementary biomarkers of AML. Their high potential to differentiate between patients from non-malignant controls but also from persons suffering from other haematological cancers (multiple myeloma and lymphoma) was demonstrated. |
| first_indexed | 2024-12-20T21:01:14Z |
| format | Article |
| id | doaj.art-4f486b4516194bc6ad4d62d1c75efe74 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T21:01:14Z |
| publishDate | 2020-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4f486b4516194bc6ad4d62d1c75efe742022-12-21T19:26:42ZengNature PortfolioScientific Reports2045-23222020-06-0110111410.1038/s41598-020-67516-2Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adultsAnna Sokołowska0Anna S. Świerzko1Gabriela Gajek2Aleksandra Gołos3Mateusz Michalski4Mateusz Nowicki5Agnieszka Szala-Poździej6Anna Wolska-Washer7Olga Brzezińska8Agnieszka Wierzbowska9Krzysztof Jamroziak10Marek L. Kowalski11Steffen Thiel12Misao Matsushita13Jens C. Jensenius14Maciej Cedzyński15Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of SciencesLaboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of SciencesLaboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of SciencesDepartment of Hematology, Institute of Hematology and Transfusion MedicineLaboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of SciencesDepartment of Hematology, Copernicus Memorial Hospital in Łódź Comprehensive Cancer Center and TraumatologyLaboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of SciencesDepartment of Hematology, Medical University of ŁódźDepartment of Immunology and Allergy, Medical University of ŁódźDepartment of Hematology, Medical University of ŁódźDepartment of Hematology, Institute of Hematology and Transfusion MedicineDepartment of Immunology and Allergy, Medical University of ŁódźDepartment of Biomedicine, Aarhus UniversityDepartment of Applied Biochemistry, Tokai UniversityDepartment of Biomedicine, Aarhus UniversityLaboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of SciencesAbstract We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as were selected polymorphisms of the corresponding genes (FCN1, FCN2, FCN3 and MBL2). The control group (C) consisted of 267 healthy unrelated individuals. Median level of ficolin-1 in patients was lower (p < 0.000001) while median levels of ficolin-2, ficolin-3 and MBL were higher (p < 0.000001, p < 0.000001 and p = 0.0016, respectively) compared with controls. These findings were generally associated with AML itself, however the highest MBL levels predicted higher risk of severe hospital infections (accompanied with bacteremia and/or fungaemia) (p = 0.012) while the lowest ficolin-1 concentrations tended to be associated with prolonged (> 7 days) fever (p = 0.026). Genotyping indicated an association of G/G homozygosity (corresponding to FCN1 gene − 542 G > A polymorphism) with malignancy [p = 0.004, OR = 2.95, 95% CI (1.41–6.16)]. Based on ROC analysis, ficolin-1, -2 and -3 may be considered candidate supplementary biomarkers of AML. Their high potential to differentiate between patients from non-malignant controls but also from persons suffering from other haematological cancers (multiple myeloma and lymphoma) was demonstrated.https://doi.org/10.1038/s41598-020-67516-2 |
| spellingShingle | Anna Sokołowska Anna S. Świerzko Gabriela Gajek Aleksandra Gołos Mateusz Michalski Mateusz Nowicki Agnieszka Szala-Poździej Anna Wolska-Washer Olga Brzezińska Agnieszka Wierzbowska Krzysztof Jamroziak Marek L. Kowalski Steffen Thiel Misao Matsushita Jens C. Jensenius Maciej Cedzyński Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults Scientific Reports |
| title | Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults |
| title_full | Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults |
| title_fullStr | Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults |
| title_full_unstemmed | Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults |
| title_short | Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults |
| title_sort | associations of ficolins and mannose binding lectin with acute myeloid leukaemia in adults |
| url | https://doi.org/10.1038/s41598-020-67516-2 |
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