Quality by Design-driven investigation of the mechanical properties of mucoadhesive films for needleless anesthetics administration

Quality by Design-driven investigation of the mechanical properties of mucoadhesive films for needleless anesthetics administration

Objectives: To systematically evaluate the effects of hydroxypropyl methyl cellulose (HPMC) type (E5LV, E15LV, and K100LV); plasticizer type (glycerol and mannitol), plasticizer loading (0.12 and 0.24% w/w); and loading of prilocaine and lidocaine hydrochlorides combined at 1:1 ratio (0 and 47 mg/cm...

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Bibliographic Details
Main Authors: Luiz Fernando Machado Ferreira, Douglas Vieira Thomaz, Maíra Peres Ferreira Duarte, Renata Fonseca Vianna Lopez, Vinícius Pedrazzi, Osvaldo de Freitas, Renê Couto
Format: Article
Language:English
Published: São Paulo State University (UNESP) 2021-03-01
Series:Revista de Ciências Farmacêuticas Básica e Aplicada
Subjects:
biocompatible materials
buccal drug administration
hypromellose derivatives
lidocaine prilocaine drug combination
multivariate analysis
polymers
Online Access:http://rcfba.fcfar.unesp.br/index.php/ojs/article/view/707

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