Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node

Cilnidipine, a dihydropyridine Ca2+ channel antagonist, is known to have inhibitory effects on both L- and N-type Ca2+ currents. In the present study, we examined the effect of cilnidipine on myocardial L- and T-type Ca2+ currents and sinoatrial node action potential configuration. In voltage clampe...

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Main Authors: Kentaro Takeda, Reiko Yamagishi, Haruko Masumiya, Hikaru Tanaka, Koki Shigenobu
Format: Article
Language:English
Published: Elsevier 2004-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319324223
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author Kentaro Takeda
Reiko Yamagishi
Haruko Masumiya
Hikaru Tanaka
Koki Shigenobu
author_facet Kentaro Takeda
Reiko Yamagishi
Haruko Masumiya
Hikaru Tanaka
Koki Shigenobu
author_sort Kentaro Takeda
collection DOAJ
description Cilnidipine, a dihydropyridine Ca2+ channel antagonist, is known to have inhibitory effects on both L- and N-type Ca2+ currents. In the present study, we examined the effect of cilnidipine on myocardial L- and T-type Ca2+ currents and sinoatrial node action potential configuration. In voltage clamped guinea pig ventricular myocytes, cilnidipine concentration-dependently decreased L- and T-type Ca2+ currents. In rabbit sinoatrial node tissue, cilnidipine increased cycle length through reduction of phase 4 depolarization slope. In conclusion, cilnidipine has inhibitory effects on T-type Ca2+ current, which may contribute to its negative chronotropic potency. Keywords:: cilnidipine, T-type Ca2+ channel, cardiomyocyte
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spelling doaj.art-4f48eff8c8d0459eb7a107526787efa62022-12-21T19:34:11ZengElsevierJournal of Pharmacological Sciences1347-86132004-01-01953398401Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial NodeKentaro Takeda0Reiko Yamagishi1Haruko Masumiya2Hikaru Tanaka3Koki Shigenobu4Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba 274-8510, JapanDepartment of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba 274-8510, JapanDepartment of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba 274-8510, JapanDepartment of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba 274-8510, Japan; Corresponding author. FAX: +81-47-472-2113 E-mail: htanaka@phar.toho-u.ac.jpDepartment of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba 274-8510, JapanCilnidipine, a dihydropyridine Ca2+ channel antagonist, is known to have inhibitory effects on both L- and N-type Ca2+ currents. In the present study, we examined the effect of cilnidipine on myocardial L- and T-type Ca2+ currents and sinoatrial node action potential configuration. In voltage clamped guinea pig ventricular myocytes, cilnidipine concentration-dependently decreased L- and T-type Ca2+ currents. In rabbit sinoatrial node tissue, cilnidipine increased cycle length through reduction of phase 4 depolarization slope. In conclusion, cilnidipine has inhibitory effects on T-type Ca2+ current, which may contribute to its negative chronotropic potency. Keywords:: cilnidipine, T-type Ca2+ channel, cardiomyocytehttp://www.sciencedirect.com/science/article/pii/S1347861319324223
spellingShingle Kentaro Takeda
Reiko Yamagishi
Haruko Masumiya
Hikaru Tanaka
Koki Shigenobu
Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node
Journal of Pharmacological Sciences
title Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node
title_full Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node
title_fullStr Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node
title_full_unstemmed Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node
title_short Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node
title_sort effect of cilnidipine on l and t type calcium currents in guinea pig ventricle and action potential in rabbit sinoatrial node
url http://www.sciencedirect.com/science/article/pii/S1347861319324223
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