Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node
Cilnidipine, a dihydropyridine Ca2+ channel antagonist, is known to have inhibitory effects on both L- and N-type Ca2+ currents. In the present study, we examined the effect of cilnidipine on myocardial L- and T-type Ca2+ currents and sinoatrial node action potential configuration. In voltage clampe...
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Elsevier
2004-01-01
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Series: | Journal of Pharmacological Sciences |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319324223 |
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author | Kentaro Takeda Reiko Yamagishi Haruko Masumiya Hikaru Tanaka Koki Shigenobu |
author_facet | Kentaro Takeda Reiko Yamagishi Haruko Masumiya Hikaru Tanaka Koki Shigenobu |
author_sort | Kentaro Takeda |
collection | DOAJ |
description | Cilnidipine, a dihydropyridine Ca2+ channel antagonist, is known to have inhibitory effects on both L- and N-type Ca2+ currents. In the present study, we examined the effect of cilnidipine on myocardial L- and T-type Ca2+ currents and sinoatrial node action potential configuration. In voltage clamped guinea pig ventricular myocytes, cilnidipine concentration-dependently decreased L- and T-type Ca2+ currents. In rabbit sinoatrial node tissue, cilnidipine increased cycle length through reduction of phase 4 depolarization slope. In conclusion, cilnidipine has inhibitory effects on T-type Ca2+ current, which may contribute to its negative chronotropic potency. Keywords:: cilnidipine, T-type Ca2+ channel, cardiomyocyte |
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institution | Directory Open Access Journal |
issn | 1347-8613 |
language | English |
last_indexed | 2024-12-20T16:05:03Z |
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spelling | doaj.art-4f48eff8c8d0459eb7a107526787efa62022-12-21T19:34:11ZengElsevierJournal of Pharmacological Sciences1347-86132004-01-01953398401Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial NodeKentaro Takeda0Reiko Yamagishi1Haruko Masumiya2Hikaru Tanaka3Koki Shigenobu4Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba 274-8510, JapanDepartment of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba 274-8510, JapanDepartment of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba 274-8510, JapanDepartment of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba 274-8510, Japan; Corresponding author. FAX: +81-47-472-2113 E-mail: htanaka@phar.toho-u.ac.jpDepartment of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba 274-8510, JapanCilnidipine, a dihydropyridine Ca2+ channel antagonist, is known to have inhibitory effects on both L- and N-type Ca2+ currents. In the present study, we examined the effect of cilnidipine on myocardial L- and T-type Ca2+ currents and sinoatrial node action potential configuration. In voltage clamped guinea pig ventricular myocytes, cilnidipine concentration-dependently decreased L- and T-type Ca2+ currents. In rabbit sinoatrial node tissue, cilnidipine increased cycle length through reduction of phase 4 depolarization slope. In conclusion, cilnidipine has inhibitory effects on T-type Ca2+ current, which may contribute to its negative chronotropic potency. Keywords:: cilnidipine, T-type Ca2+ channel, cardiomyocytehttp://www.sciencedirect.com/science/article/pii/S1347861319324223 |
spellingShingle | Kentaro Takeda Reiko Yamagishi Haruko Masumiya Hikaru Tanaka Koki Shigenobu Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node Journal of Pharmacological Sciences |
title | Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node |
title_full | Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node |
title_fullStr | Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node |
title_full_unstemmed | Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node |
title_short | Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node |
title_sort | effect of cilnidipine on l and t type calcium currents in guinea pig ventricle and action potential in rabbit sinoatrial node |
url | http://www.sciencedirect.com/science/article/pii/S1347861319324223 |
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