Endocannabinoid basis of personality—Insights from animal model of social behavior
Rationale: The endocannabinoid system is known to be involved in learning, memory, emotional processing and regulation of personality patterns. Here we assessed the endocannabinoid profile in the brains of mice with strong characteristics of social dominance and submissiveness.Methods: A lipidomics...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1234332/full |
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| author | Natalya M. Kogan Natalya M. Kogan Natalya M. Kogan Dilorom Begmatova Liudmila Vinnikova Sergey Malitsky Maxim Itkin Eyal Sharon Artem Klinov Jonathan Gorelick Igor Koman Igor Koman Zvi Vogel Raphael Mechoulam Albert Pinhasov Albert Pinhasov |
| author_facet | Natalya M. Kogan Natalya M. Kogan Natalya M. Kogan Dilorom Begmatova Liudmila Vinnikova Sergey Malitsky Maxim Itkin Eyal Sharon Artem Klinov Jonathan Gorelick Igor Koman Igor Koman Zvi Vogel Raphael Mechoulam Albert Pinhasov Albert Pinhasov |
| author_sort | Natalya M. Kogan |
| collection | DOAJ |
| description | Rationale: The endocannabinoid system is known to be involved in learning, memory, emotional processing and regulation of personality patterns. Here we assessed the endocannabinoid profile in the brains of mice with strong characteristics of social dominance and submissiveness.Methods: A lipidomics approach was employed to assess the endocannabinoidome in the brains of Dominant (Dom) and Submissive (Sub) mice. The endocannabinoid showing the greatest difference in concentration in the brain between the groups, docosatetraenoyl ethanolamine (DEA), was synthesized, and its effects on the physiological and behavioral responses of Dom and Sub mice were evaluated. mRNA expression of the endocannabinoid receptors and enzymes involved in PUFA biosynthesis was assessed using qRT-PCR.Results: Targeted LC/MS analysis revealed that long-chain polyunsaturated ethanolamides including arachidonoyl ethanolamide (AEA), DEA, docosatrienoyl ethanolamide (DTEA), eicosatrienoyl ethanolamide (ETEA), eicosapentaenoyl ethanolamide (EPEA) and docosahexaenoyl ethanolamide (DHEA) were higher in the Sub compared with the Dom mice. Untargeted LC/MS analysis showed that the parent fatty acids, docosatetraenoic (DA) and eicosapentaenoic (EPA), were higher in Sub vs. Dom. Gene expression analysis revealed increased mRNA expression of genes encoding the desaturase FADS2 and the elongase ELOVL5 in Sub mice compared with Dom mice. Acute DEA administration at the dose of 15 mg/kg produced antinociceptive and locomotion-inducing effects in Sub mice, but not in Dom mice. Subchronic treatment with DEA at the dose of 5 mg/kg augmented dominant behavior in wild-type ICR and Dom mice but not in Sub mice.Conclusion: This study suggests that the endocannabinoid system may play a role in the regulation of dominance and submissiveness, functional elements of social behavior and personality. While currently we have only scratched the surface, understanding the role of the endocannabinoid system in personality may help in revealing the mechanisms underlying the etiopathology of psychiatric disorders. |
| first_indexed | 2024-03-12T14:30:13Z |
| format | Article |
| id | doaj.art-4f4a983bb1e443faa2a911cf993a6958 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-12T14:30:13Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-4f4a983bb1e443faa2a911cf993a69582023-08-17T13:18:11ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-08-011410.3389/fphar.2023.12343321234332Endocannabinoid basis of personality—Insights from animal model of social behaviorNatalya M. Kogan0Natalya M. Kogan1Natalya M. Kogan2Dilorom Begmatova3Liudmila Vinnikova4Sergey Malitsky5Maxim Itkin6Eyal Sharon7Artem Klinov8Jonathan Gorelick9Igor Koman10Igor Koman11Zvi Vogel12Raphael Mechoulam13Albert Pinhasov14Albert Pinhasov15Department of Molecular Biology, Ariel University, Ariel, IsraelThe Institute of Personalized and Translational Medicine, Ariel University, Ariel, IsraelInstitute of Drug Research, Hebrew University, Jerusalem, IsraelDepartment of Molecular Biology, Ariel University, Ariel, IsraelDepartment of Molecular Biology, Ariel University, Ariel, IsraelLife Sciences Core Facilities, Weizmann Institute of Science, Rehovot, IsraelLife Sciences Core Facilities, Weizmann Institute of Science, Rehovot, IsraelThe Institute of Personalized and Translational Medicine, Ariel University, Ariel, IsraelDepartment of Molecular Biology, Ariel University, Ariel, IsraelEastern Regional R&D Center, Kyriat Arba, IsraelDepartment of Molecular Biology, Ariel University, Ariel, IsraelThe Institute of Personalized and Translational Medicine, Ariel University, Ariel, IsraelDepartment of Neurbiology, Weizmann Institute of Science, Rehovot, IsraelInstitute of Drug Research, Hebrew University, Jerusalem, IsraelDepartment of Molecular Biology, Ariel University, Ariel, IsraelAdelson School of Medicine, Ariel University, Ariel, IsraelRationale: The endocannabinoid system is known to be involved in learning, memory, emotional processing and regulation of personality patterns. Here we assessed the endocannabinoid profile in the brains of mice with strong characteristics of social dominance and submissiveness.Methods: A lipidomics approach was employed to assess the endocannabinoidome in the brains of Dominant (Dom) and Submissive (Sub) mice. The endocannabinoid showing the greatest difference in concentration in the brain between the groups, docosatetraenoyl ethanolamine (DEA), was synthesized, and its effects on the physiological and behavioral responses of Dom and Sub mice were evaluated. mRNA expression of the endocannabinoid receptors and enzymes involved in PUFA biosynthesis was assessed using qRT-PCR.Results: Targeted LC/MS analysis revealed that long-chain polyunsaturated ethanolamides including arachidonoyl ethanolamide (AEA), DEA, docosatrienoyl ethanolamide (DTEA), eicosatrienoyl ethanolamide (ETEA), eicosapentaenoyl ethanolamide (EPEA) and docosahexaenoyl ethanolamide (DHEA) were higher in the Sub compared with the Dom mice. Untargeted LC/MS analysis showed that the parent fatty acids, docosatetraenoic (DA) and eicosapentaenoic (EPA), were higher in Sub vs. Dom. Gene expression analysis revealed increased mRNA expression of genes encoding the desaturase FADS2 and the elongase ELOVL5 in Sub mice compared with Dom mice. Acute DEA administration at the dose of 15 mg/kg produced antinociceptive and locomotion-inducing effects in Sub mice, but not in Dom mice. Subchronic treatment with DEA at the dose of 5 mg/kg augmented dominant behavior in wild-type ICR and Dom mice but not in Sub mice.Conclusion: This study suggests that the endocannabinoid system may play a role in the regulation of dominance and submissiveness, functional elements of social behavior and personality. While currently we have only scratched the surface, understanding the role of the endocannabinoid system in personality may help in revealing the mechanisms underlying the etiopathology of psychiatric disorders.https://www.frontiersin.org/articles/10.3389/fphar.2023.1234332/fullpersonalityendocannabinoidomesocial behaviordominancesubmissivenessendocannabinoid system |
| spellingShingle | Natalya M. Kogan Natalya M. Kogan Natalya M. Kogan Dilorom Begmatova Liudmila Vinnikova Sergey Malitsky Maxim Itkin Eyal Sharon Artem Klinov Jonathan Gorelick Igor Koman Igor Koman Zvi Vogel Raphael Mechoulam Albert Pinhasov Albert Pinhasov Endocannabinoid basis of personality—Insights from animal model of social behavior Frontiers in Pharmacology personality endocannabinoidome social behavior dominance submissiveness endocannabinoid system |
| title | Endocannabinoid basis of personality—Insights from animal model of social behavior |
| title_full | Endocannabinoid basis of personality—Insights from animal model of social behavior |
| title_fullStr | Endocannabinoid basis of personality—Insights from animal model of social behavior |
| title_full_unstemmed | Endocannabinoid basis of personality—Insights from animal model of social behavior |
| title_short | Endocannabinoid basis of personality—Insights from animal model of social behavior |
| title_sort | endocannabinoid basis of personality insights from animal model of social behavior |
| topic | personality endocannabinoidome social behavior dominance submissiveness endocannabinoid system |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1234332/full |
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