Risk factors for the development of retinopathy in premature infants
Background. Retinopathy of prematurity is one of the disabling conditions in premature babies. Despite the fact that the main predictors for the development of retinopathy of prematurity are known, the factors that can potentially cause it require further study. The purpose was to determine risk fac...
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Zaslavsky O.Yu.
2022-05-01
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| Series: | Zdorovʹe Rebenka |
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| Online Access: | https://childshealth.zaslavsky.com.ua/index.php/journal/article/view/1509 |
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| author | O.Yu. Obolonska L.I. Vakulenko L.P. Badogina O.I. Obolonskyi I.A. Likhachova O.V. Kovryga |
| author_facet | O.Yu. Obolonska L.I. Vakulenko L.P. Badogina O.I. Obolonskyi I.A. Likhachova O.V. Kovryga |
| author_sort | O.Yu. Obolonska |
| collection | DOAJ |
| description | Background. Retinopathy of prematurity is one of the disabling conditions in premature babies. Despite the fact that the main predictors for the development of retinopathy of prematurity are known, the factors that can potentially cause it require further study. The purpose was to determine risk factors for the development of retinopathy in premature newborns for better control. Materials and methods. A retrospective analysis of 50 medical records of inpatient premature babies with a gestational age of 28–34 weeks and the medical charts of their mothers was carried out. Two groups were distinguished: the first one — 29 children with retinopathy, the second one — 21 patient without retinopathy. Results. The vast majority of children — 38 (76.0 %) were born at a gestational age of 28–31 weeks. Differences between groups were not significant. The analysis showed that 14 (48.3 %) premature children were diagnosed with stage I retinopathy, 6 (20.7 %) — with stage II, 5 (17.2 %) — with stage ІІІ and 4 (13.8 %) — with stage IV. The most influential risk factors for the development of retinopathy of prematurity were identified. The presence of retinopathy significantly correlated with gestational age of less than 34 weeks (ρ = 0.64, p < 0.001), need for oxygen subsidy ≥ 40 % (ρ = 0.59, р < 0.001), development of bronchopulmonary dysplasia (ρ = 0.34, р < 0.01), sepsis (ρ = 0.59, р < 0.001), intraventricular hemorrhages (ρ = 0.56, р < 0.001). It was also found that the presence of a burdened maternal history in the form of chronic foci of infection and chorioamnionitis is a significant risk factor for the development of retinopathy (ρ = 0.56, р < 0.001). Moreover, the presence of an infection in the mother increased the risk of retinopathy stage III–IV in a child by 3.8 times (p < 0.05), and stage I–II retinopathy — by 5 times. With a combination of chorioamnionitis and chronic foci of infection, the risk of developing severe retinopathy was almost 95 % (р < 0.007). Conclusions. Burdened maternal history in the form of chronic foci of infection and/or choriamnionitis is an important risk factor for the development of retinopathy in children. Chorioamnionitis is a predictor of severe retinopathy. Treatment of chronic foci of infection in pregnant women should be considered as a mandatory measure to prevent retinopathy in premature newborns. |
| first_indexed | 2024-03-13T07:20:00Z |
| format | Article |
| id | doaj.art-4f4afd33538c4092917f4211887cd715 |
| institution | Directory Open Access Journal |
| issn | 2224-0551 2307-1168 |
| language | English |
| last_indexed | 2024-03-13T07:20:00Z |
| publishDate | 2022-05-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Zdorovʹe Rebenka |
| spelling | doaj.art-4f4afd33538c4092917f4211887cd7152023-06-04T15:30:12ZengZaslavsky O.Yu.Zdorovʹe Rebenka2224-05512307-11682022-05-0117313814310.22141/2224-0551.17.3.2022.15091509Risk factors for the development of retinopathy in premature infantsO.Yu. Obolonska0https://orcid.org/0000-0001-9863-1828L.I. Vakulenko1https://orcid.org/0000-0003-3823-6134L.P. Badogina2https://orcid.org/0000-0002-2971-9815O.I. Obolonskyi3https://orcid.org/0000-0002-3190-0402I.A. Likhachova4https://orcid.org/0000-0003-3283-5160O.V. Kovryga5Dnipro State Medical University, Dnipro, UkraineDnipro State Medical University, Dnipro, UkraineDnipro State Medical University, Dnipro, UkraineMunicipal Enterprise “Dnipropetrovsk Regional Children’s Clinical Hospital of Dnipropetrovsk Regional Council”, Dnipro, UkraineMunicipal Enterprise “Dnipropetrovsk Regional Children’s Clinical Hospital of Dnipropetrovsk Regional Council”, Dnipro, UkraineDnipro State Medical University, Dnipro, UkraineBackground. Retinopathy of prematurity is one of the disabling conditions in premature babies. Despite the fact that the main predictors for the development of retinopathy of prematurity are known, the factors that can potentially cause it require further study. The purpose was to determine risk factors for the development of retinopathy in premature newborns for better control. Materials and methods. A retrospective analysis of 50 medical records of inpatient premature babies with a gestational age of 28–34 weeks and the medical charts of their mothers was carried out. Two groups were distinguished: the first one — 29 children with retinopathy, the second one — 21 patient without retinopathy. Results. The vast majority of children — 38 (76.0 %) were born at a gestational age of 28–31 weeks. Differences between groups were not significant. The analysis showed that 14 (48.3 %) premature children were diagnosed with stage I retinopathy, 6 (20.7 %) — with stage II, 5 (17.2 %) — with stage ІІІ and 4 (13.8 %) — with stage IV. The most influential risk factors for the development of retinopathy of prematurity were identified. The presence of retinopathy significantly correlated with gestational age of less than 34 weeks (ρ = 0.64, p < 0.001), need for oxygen subsidy ≥ 40 % (ρ = 0.59, р < 0.001), development of bronchopulmonary dysplasia (ρ = 0.34, р < 0.01), sepsis (ρ = 0.59, р < 0.001), intraventricular hemorrhages (ρ = 0.56, р < 0.001). It was also found that the presence of a burdened maternal history in the form of chronic foci of infection and chorioamnionitis is a significant risk factor for the development of retinopathy (ρ = 0.56, р < 0.001). Moreover, the presence of an infection in the mother increased the risk of retinopathy stage III–IV in a child by 3.8 times (p < 0.05), and stage I–II retinopathy — by 5 times. With a combination of chorioamnionitis and chronic foci of infection, the risk of developing severe retinopathy was almost 95 % (р < 0.007). Conclusions. Burdened maternal history in the form of chronic foci of infection and/or choriamnionitis is an important risk factor for the development of retinopathy in children. Chorioamnionitis is a predictor of severe retinopathy. Treatment of chronic foci of infection in pregnant women should be considered as a mandatory measure to prevent retinopathy in premature newborns.https://childshealth.zaslavsky.com.ua/index.php/journal/article/view/1509retinopathy of prematurityrisk factorschronic foci of infectionchorioamnionitis |
| spellingShingle | O.Yu. Obolonska L.I. Vakulenko L.P. Badogina O.I. Obolonskyi I.A. Likhachova O.V. Kovryga Risk factors for the development of retinopathy in premature infants Zdorovʹe Rebenka retinopathy of prematurity risk factors chronic foci of infection chorioamnionitis |
| title | Risk factors for the development of retinopathy in premature infants |
| title_full | Risk factors for the development of retinopathy in premature infants |
| title_fullStr | Risk factors for the development of retinopathy in premature infants |
| title_full_unstemmed | Risk factors for the development of retinopathy in premature infants |
| title_short | Risk factors for the development of retinopathy in premature infants |
| title_sort | risk factors for the development of retinopathy in premature infants |
| topic | retinopathy of prematurity risk factors chronic foci of infection chorioamnionitis |
| url | https://childshealth.zaslavsky.com.ua/index.php/journal/article/view/1509 |
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