The Effects of Berry Polyphenols on the Gut Microbiota and Blood Pressure: A Systematic Review of Randomized Clinical Trials in Humans
Berry consumption has beneficial effects on blood pressure. Intestinal microbiota transform berry phytochemicals into more bioactive forms. Thus, we performed a systematic review of randomized clinical trials to determine whether berry polyphenols in foods, extracts or supplements have effects on bo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/11/2263 |
| _version_ | 1797492223916376064 |
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| author | Marva Sweeney Gracie Burns Nora Sturgeon Kim Mears Kim Stote Cynthia Blanton |
| author_facet | Marva Sweeney Gracie Burns Nora Sturgeon Kim Mears Kim Stote Cynthia Blanton |
| author_sort | Marva Sweeney |
| collection | DOAJ |
| description | Berry consumption has beneficial effects on blood pressure. Intestinal microbiota transform berry phytochemicals into more bioactive forms. Thus, we performed a systematic review of randomized clinical trials to determine whether berry polyphenols in foods, extracts or supplements have effects on both the profile of gut microbiota and systolic and diastolic blood pressure in humans. PubMed, Cochrane Library, Scopus, and CAB Abstracts (EBSCOhost) were searched for randomized clinical trials in humans published from 1 January 2011 to 29 October 2021. Search results were imported into Covidence for screening and data extraction by two blinded reviewers, who also performed bias assessment independently. The literature search identified 216 publications; after duplicates were removed, 168 publications were screened with 12 full-text publications assessed for eligibility. Ultimately three randomized clinical trials in humans met the eligibility criteria. One randomized clinical trial showed a low risk of bias while the other two randomized clinical trials included low, high or unclear risk of bias. Together the randomized clinical trials showed that berry consumption (Aronia berry, strawberries, raspberries, cloudberries and bilberries) for 8–12 weeks had no significant effect on both blood pressure and the gut microbiota. More randomized clinical trials are needed to determine the effects of berry consumption on the profile of gut microbiota and blood pressure in humans. |
| first_indexed | 2024-03-10T01:00:32Z |
| format | Article |
| id | doaj.art-4f4ca070eb3d4145b004f8331345a933 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T01:00:32Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-4f4ca070eb3d4145b004f8331345a9332023-11-23T14:36:14ZengMDPI AGNutrients2072-66432022-05-011411226310.3390/nu14112263The Effects of Berry Polyphenols on the Gut Microbiota and Blood Pressure: A Systematic Review of Randomized Clinical Trials in HumansMarva Sweeney0Gracie Burns1Nora Sturgeon2Kim Mears3Kim Stote4Cynthia Blanton5Department of Biology, University of Prince Edward Island, Charlottetown, PE C1A 4P3, CanadaDepartment of Biology, University of Prince Edward Island, Charlottetown, PE C1A 4P3, CanadaDepartment of Applied Human Sciences, University of Prince Edward Island, Charlottetown, PE C1A 4P3, CanadaRobertson Library, University of Prince Edward Island, Charlottetown, PE C1A 4P3, CanadaDepartment of Allied Health Sciences, State University of New York, Empire State College, Saratoga Springs, NY 12866, USADepartment of Nutrition and Dietetics, Idaho State University, Pocatello, ID 83201, USABerry consumption has beneficial effects on blood pressure. Intestinal microbiota transform berry phytochemicals into more bioactive forms. Thus, we performed a systematic review of randomized clinical trials to determine whether berry polyphenols in foods, extracts or supplements have effects on both the profile of gut microbiota and systolic and diastolic blood pressure in humans. PubMed, Cochrane Library, Scopus, and CAB Abstracts (EBSCOhost) were searched for randomized clinical trials in humans published from 1 January 2011 to 29 October 2021. Search results were imported into Covidence for screening and data extraction by two blinded reviewers, who also performed bias assessment independently. The literature search identified 216 publications; after duplicates were removed, 168 publications were screened with 12 full-text publications assessed for eligibility. Ultimately three randomized clinical trials in humans met the eligibility criteria. One randomized clinical trial showed a low risk of bias while the other two randomized clinical trials included low, high or unclear risk of bias. Together the randomized clinical trials showed that berry consumption (Aronia berry, strawberries, raspberries, cloudberries and bilberries) for 8–12 weeks had no significant effect on both blood pressure and the gut microbiota. More randomized clinical trials are needed to determine the effects of berry consumption on the profile of gut microbiota and blood pressure in humans.https://www.mdpi.com/2072-6643/14/11/2263berriespolyphenolsblood pressureintestinal microbiotarandomized controlled trials |
| spellingShingle | Marva Sweeney Gracie Burns Nora Sturgeon Kim Mears Kim Stote Cynthia Blanton The Effects of Berry Polyphenols on the Gut Microbiota and Blood Pressure: A Systematic Review of Randomized Clinical Trials in Humans Nutrients berries polyphenols blood pressure intestinal microbiota randomized controlled trials |
| title | The Effects of Berry Polyphenols on the Gut Microbiota and Blood Pressure: A Systematic Review of Randomized Clinical Trials in Humans |
| title_full | The Effects of Berry Polyphenols on the Gut Microbiota and Blood Pressure: A Systematic Review of Randomized Clinical Trials in Humans |
| title_fullStr | The Effects of Berry Polyphenols on the Gut Microbiota and Blood Pressure: A Systematic Review of Randomized Clinical Trials in Humans |
| title_full_unstemmed | The Effects of Berry Polyphenols on the Gut Microbiota and Blood Pressure: A Systematic Review of Randomized Clinical Trials in Humans |
| title_short | The Effects of Berry Polyphenols on the Gut Microbiota and Blood Pressure: A Systematic Review of Randomized Clinical Trials in Humans |
| title_sort | effects of berry polyphenols on the gut microbiota and blood pressure a systematic review of randomized clinical trials in humans |
| topic | berries polyphenols blood pressure intestinal microbiota randomized controlled trials |
| url | https://www.mdpi.com/2072-6643/14/11/2263 |
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