A New Methodology to Assess Fallopian Tubes Microbiota and Its Impact on Female Fertility
Tubal factor is an important contributor to female infertility, and the current diagnostic approaches cannot correctly identify many subtle causes of tubal dysfunction. While it is known that the most common cause of tubal factor infertility is pelvic inflammatory disease (PID), creating critical al...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/6/1375 |
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| author | Salvatore Giovanni Vitale Jose Carugno Maurizio Nicola D’Alterio Mislav Mikuš Pasquale Patrizio Stefano Angioni |
| author_facet | Salvatore Giovanni Vitale Jose Carugno Maurizio Nicola D’Alterio Mislav Mikuš Pasquale Patrizio Stefano Angioni |
| author_sort | Salvatore Giovanni Vitale |
| collection | DOAJ |
| description | Tubal factor is an important contributor to female infertility, and the current diagnostic approaches cannot correctly identify many subtle causes of tubal dysfunction. While it is known that the most common cause of tubal factor infertility is pelvic inflammatory disease (PID), creating critical alterations of the tubal epithelium, little attention has been devoted to understanding the tubal modifications caused by the resident microbial population and their interaction with the surrounding tubal epithelium. Furthermore, most of these samples are obtained by traumatic procedures such as direct sampling during laparoscopy using a cytobrush. However, as in any other organ of the female genital tract, the microbiota environment of the fallopian tube plays an essential role in maintaining tubal functioning, counteracting the pathogenic effect of acquired microbes. Consequentially, to better analyze the tubal microbiota without causing anatomical and/or functional alteration of the fallopian tube and preserving fertility, the hysteroscopic approach might be the method of choice, guarantying maximal integrity of the uterine cavity and tubal lumen. Here we describe our plan for using atraumatic hysteroscopic sampling methods to investigate the correlation between tubal microbiota and female infertility. |
| first_indexed | 2024-03-10T00:00:15Z |
| format | Article |
| id | doaj.art-4f4d9067b19849688e6c73011fc8bdde |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T00:00:15Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-4f4d9067b19849688e6c73011fc8bdde2023-11-23T16:17:07ZengMDPI AGDiagnostics2075-44182022-06-01126137510.3390/diagnostics12061375A New Methodology to Assess Fallopian Tubes Microbiota and Its Impact on Female FertilitySalvatore Giovanni Vitale0Jose Carugno1Maurizio Nicola D’Alterio2Mislav Mikuš3Pasquale Patrizio4Stefano Angioni5Obstetrics and Gynecology Unit, Department of General Surgery and Medical Surgical Specialties, University of Catania, 95124 Catania, ItalyMinimally Invasive Gynecology Unit, Obstetrics, Gynecology and Reproductive Sciences Department, Miller School of Medicine, University of Miami, Miami, FL 33136, USADivision of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, 09042 Cagliari, ItalyDepartment of Obstetrics and Gynecology, University Hospital Center Zagreb, 10000 Zagreb, CroatiaMinimally Invasive Gynecology Unit, Obstetrics, Gynecology and Reproductive Sciences Department, Miller School of Medicine, University of Miami, Miami, FL 33136, USADivision of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari, 09042 Cagliari, ItalyTubal factor is an important contributor to female infertility, and the current diagnostic approaches cannot correctly identify many subtle causes of tubal dysfunction. While it is known that the most common cause of tubal factor infertility is pelvic inflammatory disease (PID), creating critical alterations of the tubal epithelium, little attention has been devoted to understanding the tubal modifications caused by the resident microbial population and their interaction with the surrounding tubal epithelium. Furthermore, most of these samples are obtained by traumatic procedures such as direct sampling during laparoscopy using a cytobrush. However, as in any other organ of the female genital tract, the microbiota environment of the fallopian tube plays an essential role in maintaining tubal functioning, counteracting the pathogenic effect of acquired microbes. Consequentially, to better analyze the tubal microbiota without causing anatomical and/or functional alteration of the fallopian tube and preserving fertility, the hysteroscopic approach might be the method of choice, guarantying maximal integrity of the uterine cavity and tubal lumen. Here we describe our plan for using atraumatic hysteroscopic sampling methods to investigate the correlation between tubal microbiota and female infertility.https://www.mdpi.com/2075-4418/12/6/1375female infertilityhysteroscopylaparoscopypelvic inflammatory disease (PID)tubal microbiota |
| spellingShingle | Salvatore Giovanni Vitale Jose Carugno Maurizio Nicola D’Alterio Mislav Mikuš Pasquale Patrizio Stefano Angioni A New Methodology to Assess Fallopian Tubes Microbiota and Its Impact on Female Fertility Diagnostics female infertility hysteroscopy laparoscopy pelvic inflammatory disease (PID) tubal microbiota |
| title | A New Methodology to Assess Fallopian Tubes Microbiota and Its Impact on Female Fertility |
| title_full | A New Methodology to Assess Fallopian Tubes Microbiota and Its Impact on Female Fertility |
| title_fullStr | A New Methodology to Assess Fallopian Tubes Microbiota and Its Impact on Female Fertility |
| title_full_unstemmed | A New Methodology to Assess Fallopian Tubes Microbiota and Its Impact on Female Fertility |
| title_short | A New Methodology to Assess Fallopian Tubes Microbiota and Its Impact on Female Fertility |
| title_sort | new methodology to assess fallopian tubes microbiota and its impact on female fertility |
| topic | female infertility hysteroscopy laparoscopy pelvic inflammatory disease (PID) tubal microbiota |
| url | https://www.mdpi.com/2075-4418/12/6/1375 |
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