Association between Obesity Indexes and Thyroid Cancer Risk in Korean Women: Nested Case–Control Study
Objective: This study aimed to identify the association between various obesity indexes, including waist circumference (WC), waist–hip ratio (WHR), waist–height ratio (WHTR), and BMI, and their combinations with body mass index (BMI) and thyroid cancer risk. Methods: Of the 65,639 participants who c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/19/4712 |
| _version_ | 1797480265553018880 |
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| author | Yoonyoung Jang Taehwa Kim Brian H. S. Kim Boyoung Park |
| author_facet | Yoonyoung Jang Taehwa Kim Brian H. S. Kim Boyoung Park |
| author_sort | Yoonyoung Jang |
| collection | DOAJ |
| description | Objective: This study aimed to identify the association between various obesity indexes, including waist circumference (WC), waist–hip ratio (WHR), waist–height ratio (WHTR), and BMI, and their combinations with body mass index (BMI) and thyroid cancer risk. Methods: Of the 65,639 participants who completed a follow-up survey of the Health Examinee Study (HEXA), a prospective cohort of the Korean Genome and Epidemiology Study, 412 female incident thyroid cancer cases, and 1648 birth year- and enrollment year-matched female controls were included. Multiple conditional logistic regression was used to estimate the association between obesity indexes and thyroid cancer risk. Results: The risk of developing thyroid cancer was increased by 1.37-fold (95% confidence interval (CI) = 1.03–1.81) higher in the obese BMI group (≥25.0 Kg/m<sup>2</sup>) compared to that in the normal BMI group (<23.0 Kg/m<sup>2</sup>). Obesity in terms of WC (≥85.0 cm) and WHTR (≥0.5) was associated with an increased risk of thyroid cancer (OR 1.55, 95% CI = 1.16–2.07; OR 1.37, 95% CI = 1.07–1.75, respectively). However, increased WHR levels did not show any significant association. Women with both obese levels of BMI (≥25.0 Kg/m<sup>2</sup>) and other obesity indexes (WC ≥ 85.0 cm, WHR ≥ 0.85, or WHTR ≥ 0.5) showed an increased risk of thyroid cancer with OR of 1.63 (95% CI = 1.14–2.31), 1.49 (95% CI = 1.05–2.12), and 1.42 (95% CI = 1.04–1.94), compared to those with normal levels of BMI and each obesity index. Conclusion: These results provide evidence of the contribution of both total and central adiposity across the lifespan of thyroid cancer incidence. Risk factor modifications must be considered to explain the current thyroid cancer epidemic. |
| first_indexed | 2024-03-09T21:57:33Z |
| format | Article |
| id | doaj.art-4f4e185f7c624bbc9246f8d8449545b9 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T21:57:33Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4f4e185f7c624bbc9246f8d8449545b92023-11-23T19:55:22ZengMDPI AGCancers2072-66942022-09-011419471210.3390/cancers14194712Association between Obesity Indexes and Thyroid Cancer Risk in Korean Women: Nested Case–Control StudyYoonyoung Jang0Taehwa Kim1Brian H. S. Kim2Boyoung Park3Department of Preventive Medicine, Hanyang University College of Medicine, Seoul 04763, KoreaDepartment of Preventive Medicine, Hanyang University College of Medicine, Seoul 04763, KoreaProgram in Regional Information, Department of Agricultural Economics and Rural Development, Seoul National University, Seoul 08826, KoreaDepartment of Preventive Medicine, Hanyang University College of Medicine, Seoul 04763, KoreaObjective: This study aimed to identify the association between various obesity indexes, including waist circumference (WC), waist–hip ratio (WHR), waist–height ratio (WHTR), and BMI, and their combinations with body mass index (BMI) and thyroid cancer risk. Methods: Of the 65,639 participants who completed a follow-up survey of the Health Examinee Study (HEXA), a prospective cohort of the Korean Genome and Epidemiology Study, 412 female incident thyroid cancer cases, and 1648 birth year- and enrollment year-matched female controls were included. Multiple conditional logistic regression was used to estimate the association between obesity indexes and thyroid cancer risk. Results: The risk of developing thyroid cancer was increased by 1.37-fold (95% confidence interval (CI) = 1.03–1.81) higher in the obese BMI group (≥25.0 Kg/m<sup>2</sup>) compared to that in the normal BMI group (<23.0 Kg/m<sup>2</sup>). Obesity in terms of WC (≥85.0 cm) and WHTR (≥0.5) was associated with an increased risk of thyroid cancer (OR 1.55, 95% CI = 1.16–2.07; OR 1.37, 95% CI = 1.07–1.75, respectively). However, increased WHR levels did not show any significant association. Women with both obese levels of BMI (≥25.0 Kg/m<sup>2</sup>) and other obesity indexes (WC ≥ 85.0 cm, WHR ≥ 0.85, or WHTR ≥ 0.5) showed an increased risk of thyroid cancer with OR of 1.63 (95% CI = 1.14–2.31), 1.49 (95% CI = 1.05–2.12), and 1.42 (95% CI = 1.04–1.94), compared to those with normal levels of BMI and each obesity index. Conclusion: These results provide evidence of the contribution of both total and central adiposity across the lifespan of thyroid cancer incidence. Risk factor modifications must be considered to explain the current thyroid cancer epidemic.https://www.mdpi.com/2072-6694/14/19/4712thyroid cancer in womennested case–control studyrisk factorobesity |
| spellingShingle | Yoonyoung Jang Taehwa Kim Brian H. S. Kim Boyoung Park Association between Obesity Indexes and Thyroid Cancer Risk in Korean Women: Nested Case–Control Study Cancers thyroid cancer in women nested case–control study risk factor obesity |
| title | Association between Obesity Indexes and Thyroid Cancer Risk in Korean Women: Nested Case–Control Study |
| title_full | Association between Obesity Indexes and Thyroid Cancer Risk in Korean Women: Nested Case–Control Study |
| title_fullStr | Association between Obesity Indexes and Thyroid Cancer Risk in Korean Women: Nested Case–Control Study |
| title_full_unstemmed | Association between Obesity Indexes and Thyroid Cancer Risk in Korean Women: Nested Case–Control Study |
| title_short | Association between Obesity Indexes and Thyroid Cancer Risk in Korean Women: Nested Case–Control Study |
| title_sort | association between obesity indexes and thyroid cancer risk in korean women nested case control study |
| topic | thyroid cancer in women nested case–control study risk factor obesity |
| url | https://www.mdpi.com/2072-6694/14/19/4712 |
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