P123 Beyond Diameters, Flow Hemodynamics Quantified by Magnetic Resonance Imaging to Help Characterizing Aneurysmal Aorta
Purpose: Referral to surgery in thoracic aortic aneurysms (TAA) is based on maximal diameter (Dmax) measured from imaging, which is known to have a high diagnosis failure rate. In addition to geometry, 4D flow MRI provides a comprehensive time-resolved flow imaging. Thus, our aim was to evaluate the...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-02-01
|
| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125934617/view |
| _version_ | 1828531173590040576 |
|---|---|
| author | Sophia Houriez—Gombaud-Saintonge Ariel Pascaner Gilles Soulat Umit Gencer Thomas Dietenbeck Damian Craiem Emilie Bollache Yasmina Chenoune Elie Mousseaux Nadjia Kachenoura |
| author_facet | Sophia Houriez—Gombaud-Saintonge Ariel Pascaner Gilles Soulat Umit Gencer Thomas Dietenbeck Damian Craiem Emilie Bollache Yasmina Chenoune Elie Mousseaux Nadjia Kachenoura |
| author_sort | Sophia Houriez—Gombaud-Saintonge |
| collection | DOAJ |
| description | Purpose: Referral to surgery in thoracic aortic aneurysms (TAA) is based on maximal diameter (Dmax) measured from imaging, which is known to have a high diagnosis failure rate. In addition to geometry, 4D flow MRI provides a comprehensive time-resolved flow imaging. Thus, our aim was to evaluate the ability of 4D flow MRI-derived quantitative flow indices to characterize TAA.
Methods: We studied 20 patients with TAA and tricuspid valve (TAVd, Dmax = 43 ± 5 mm, Age = 66 ± 14 years) and 56 healthy controls (YC: 30 subjects, Age = 36 ± 9 years ≤50 years, OC: 26 subjects, Age = 65 ± 9 years > 50 years). All underwent 4D flow MRI. After aortic segmentation, ascending aorta (AA) backward flow volume (VBF) was calculated in addition to maximal velocity jet angle and eccentricity (Ecc). Receiver operating characteristic analysis was performed to assess the ability of flow indices to characterize AA = dilation.
Results: While AA Dmax was 1.4-fold higher in TAVd than OC, VBF increased by 6.5 folds and Ecc and Angle varied by 1.3 to 1.7 folds between the two groups. Moreover, VBF changed by 12.7 folds between the aneurysmal AA as compared to TAVd descending aorta. Finally, VBF increased consistently with age in all controls and was able to detect AA dilation with a 0.98 accuracy.
Conclusion: AA backward flow quantified from 4D flow MRI outperformed the previously described indices such as flow eccentricity and angle in the characterization of thoracic aortic aneurysms. |
| first_indexed | 2024-12-11T22:34:39Z |
| format | Article |
| id | doaj.art-4f5130d4ff0540039ea9954234f65218 |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-12-11T22:34:39Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-4f5130d4ff0540039ea9954234f652182022-12-22T00:48:01ZengBMCArtery Research1876-44012020-02-0125110.2991/artres.k.191224.149P123 Beyond Diameters, Flow Hemodynamics Quantified by Magnetic Resonance Imaging to Help Characterizing Aneurysmal AortaSophia Houriez—Gombaud-SaintongeAriel PascanerGilles SoulatUmit GencerThomas DietenbeckDamian CraiemEmilie BollacheYasmina ChenouneElie MousseauxNadjia KachenouraPurpose: Referral to surgery in thoracic aortic aneurysms (TAA) is based on maximal diameter (Dmax) measured from imaging, which is known to have a high diagnosis failure rate. In addition to geometry, 4D flow MRI provides a comprehensive time-resolved flow imaging. Thus, our aim was to evaluate the ability of 4D flow MRI-derived quantitative flow indices to characterize TAA. Methods: We studied 20 patients with TAA and tricuspid valve (TAVd, Dmax = 43 ± 5 mm, Age = 66 ± 14 years) and 56 healthy controls (YC: 30 subjects, Age = 36 ± 9 years ≤50 years, OC: 26 subjects, Age = 65 ± 9 years > 50 years). All underwent 4D flow MRI. After aortic segmentation, ascending aorta (AA) backward flow volume (VBF) was calculated in addition to maximal velocity jet angle and eccentricity (Ecc). Receiver operating characteristic analysis was performed to assess the ability of flow indices to characterize AA = dilation. Results: While AA Dmax was 1.4-fold higher in TAVd than OC, VBF increased by 6.5 folds and Ecc and Angle varied by 1.3 to 1.7 folds between the two groups. Moreover, VBF changed by 12.7 folds between the aneurysmal AA as compared to TAVd descending aorta. Finally, VBF increased consistently with age in all controls and was able to detect AA dilation with a 0.98 accuracy. Conclusion: AA backward flow quantified from 4D flow MRI outperformed the previously described indices such as flow eccentricity and angle in the characterization of thoracic aortic aneurysms.https://www.atlantis-press.com/article/125934617/view |
| spellingShingle | Sophia Houriez—Gombaud-Saintonge Ariel Pascaner Gilles Soulat Umit Gencer Thomas Dietenbeck Damian Craiem Emilie Bollache Yasmina Chenoune Elie Mousseaux Nadjia Kachenoura P123 Beyond Diameters, Flow Hemodynamics Quantified by Magnetic Resonance Imaging to Help Characterizing Aneurysmal Aorta Artery Research |
| title | P123 Beyond Diameters, Flow Hemodynamics Quantified by Magnetic Resonance Imaging to Help Characterizing Aneurysmal Aorta |
| title_full | P123 Beyond Diameters, Flow Hemodynamics Quantified by Magnetic Resonance Imaging to Help Characterizing Aneurysmal Aorta |
| title_fullStr | P123 Beyond Diameters, Flow Hemodynamics Quantified by Magnetic Resonance Imaging to Help Characterizing Aneurysmal Aorta |
| title_full_unstemmed | P123 Beyond Diameters, Flow Hemodynamics Quantified by Magnetic Resonance Imaging to Help Characterizing Aneurysmal Aorta |
| title_short | P123 Beyond Diameters, Flow Hemodynamics Quantified by Magnetic Resonance Imaging to Help Characterizing Aneurysmal Aorta |
| title_sort | p123 beyond diameters flow hemodynamics quantified by magnetic resonance imaging to help characterizing aneurysmal aorta |
| url | https://www.atlantis-press.com/article/125934617/view |
| work_keys_str_mv | AT sophiahouriezgombaudsaintonge p123beyonddiametersflowhemodynamicsquantifiedbymagneticresonanceimagingtohelpcharacterizinganeurysmalaorta AT arielpascaner p123beyonddiametersflowhemodynamicsquantifiedbymagneticresonanceimagingtohelpcharacterizinganeurysmalaorta AT gillessoulat p123beyonddiametersflowhemodynamicsquantifiedbymagneticresonanceimagingtohelpcharacterizinganeurysmalaorta AT umitgencer p123beyonddiametersflowhemodynamicsquantifiedbymagneticresonanceimagingtohelpcharacterizinganeurysmalaorta AT thomasdietenbeck p123beyonddiametersflowhemodynamicsquantifiedbymagneticresonanceimagingtohelpcharacterizinganeurysmalaorta AT damiancraiem p123beyonddiametersflowhemodynamicsquantifiedbymagneticresonanceimagingtohelpcharacterizinganeurysmalaorta AT emiliebollache p123beyonddiametersflowhemodynamicsquantifiedbymagneticresonanceimagingtohelpcharacterizinganeurysmalaorta AT yasminachenoune p123beyonddiametersflowhemodynamicsquantifiedbymagneticresonanceimagingtohelpcharacterizinganeurysmalaorta AT eliemousseaux p123beyonddiametersflowhemodynamicsquantifiedbymagneticresonanceimagingtohelpcharacterizinganeurysmalaorta AT nadjiakachenoura p123beyonddiametersflowhemodynamicsquantifiedbymagneticresonanceimagingtohelpcharacterizinganeurysmalaorta |