The associations between gut microbiota and inflammatory skin diseases: a bi-directional two-sample Mendelian randomization study
BackgroundAccumulating evidence shows that dysregulation of intestinal flora is associated with inflammatory skin diseases, specifically atopic dermatitis (AD), psoriasis (PSO), and rosacea (ROS). However, the causality is still unclear.ObjectivesTo study the underlying causality between gut microbi...
| المؤلفون الرئيسيون: | , , , |
|---|---|
| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
Frontiers Media S.A.
2024-02-01
|
| سلاسل: | Frontiers in Immunology |
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1297240/full |
| _version_ | 1827365238855434240 |
|---|---|
| author | Yun Zhong Yun Zhong Fan Wang Xin Meng Lei Zhou |
| author_facet | Yun Zhong Yun Zhong Fan Wang Xin Meng Lei Zhou |
| author_sort | Yun Zhong |
| collection | DOAJ |
| description | BackgroundAccumulating evidence shows that dysregulation of intestinal flora is associated with inflammatory skin diseases, specifically atopic dermatitis (AD), psoriasis (PSO), and rosacea (ROS). However, the causality is still unclear.ObjectivesTo study the underlying causality between gut microbiota (GM) and AD, PSO, and ROS, a bi-directional two-sample Mendelian randomization (2SMR) analysis was conducted.MethodsSummary statistics of gut microbiota, AD, PSO, and ROS were extracted from large-scale genome-wide association studies (GWASs). In 2SMR analysis, in addition to the inverse variance weighted as the principal method for evaluating causal association, four different methods were also used. Sensitivity analysis and reverse 2SMR study were implemented to evaluate the robustness of 2SMR results or reverse causal relationship, respectively.ResultsA total of 24 specific gut microbiota species related to AD, PSO, and ROS were identified by 2SMR analysis. After using the Bonferroni method for multiple testing correction, family FamilyXIII (ID: 1957) [OR = 1.28 (1.13, 1.45), p = 9.26e−05] and genus Eubacteriumfissicatenagroup (ID: 14373) [OR = 1.20 (1.09, 1.33), p = 1.65e−04] were associated with an increased risk for AD and PSO, respectively. The genus Dialister showed a negative association, suggesting a protective role against both atopic dermatitis and rosacea. Our reverse 2SMR analysis indicated no reverse causality between these inflammatory skin diseases and the identified gut microbiota.ConclusionsIn summary, this study provided evidence for the causality between GM and inflammatory skin diseases. These findings suggested that supplementing specific bacterial taxa may be an effective therapy for AD, PSO, and ROS. |
| first_indexed | 2024-03-08T08:25:23Z |
| format | Article |
| id | doaj.art-4f55b7cee4ea4ad1aff3f3a901b4a0c5 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T08:25:23Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-4f55b7cee4ea4ad1aff3f3a901b4a0c52024-02-02T04:48:20ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.12972401297240The associations between gut microbiota and inflammatory skin diseases: a bi-directional two-sample Mendelian randomization studyYun Zhong0Yun Zhong1Fan Wang2Xin Meng3Lei Zhou4Department of Dermatology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaBackgroundAccumulating evidence shows that dysregulation of intestinal flora is associated with inflammatory skin diseases, specifically atopic dermatitis (AD), psoriasis (PSO), and rosacea (ROS). However, the causality is still unclear.ObjectivesTo study the underlying causality between gut microbiota (GM) and AD, PSO, and ROS, a bi-directional two-sample Mendelian randomization (2SMR) analysis was conducted.MethodsSummary statistics of gut microbiota, AD, PSO, and ROS were extracted from large-scale genome-wide association studies (GWASs). In 2SMR analysis, in addition to the inverse variance weighted as the principal method for evaluating causal association, four different methods were also used. Sensitivity analysis and reverse 2SMR study were implemented to evaluate the robustness of 2SMR results or reverse causal relationship, respectively.ResultsA total of 24 specific gut microbiota species related to AD, PSO, and ROS were identified by 2SMR analysis. After using the Bonferroni method for multiple testing correction, family FamilyXIII (ID: 1957) [OR = 1.28 (1.13, 1.45), p = 9.26e−05] and genus Eubacteriumfissicatenagroup (ID: 14373) [OR = 1.20 (1.09, 1.33), p = 1.65e−04] were associated with an increased risk for AD and PSO, respectively. The genus Dialister showed a negative association, suggesting a protective role against both atopic dermatitis and rosacea. Our reverse 2SMR analysis indicated no reverse causality between these inflammatory skin diseases and the identified gut microbiota.ConclusionsIn summary, this study provided evidence for the causality between GM and inflammatory skin diseases. These findings suggested that supplementing specific bacterial taxa may be an effective therapy for AD, PSO, and ROS.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1297240/fullatopic dermatitisgut microbiotaMendelian randomizationpsoriasisrosacea |
| spellingShingle | Yun Zhong Yun Zhong Fan Wang Xin Meng Lei Zhou The associations between gut microbiota and inflammatory skin diseases: a bi-directional two-sample Mendelian randomization study Frontiers in Immunology atopic dermatitis gut microbiota Mendelian randomization psoriasis rosacea |
| title | The associations between gut microbiota and inflammatory skin diseases: a bi-directional two-sample Mendelian randomization study |
| title_full | The associations between gut microbiota and inflammatory skin diseases: a bi-directional two-sample Mendelian randomization study |
| title_fullStr | The associations between gut microbiota and inflammatory skin diseases: a bi-directional two-sample Mendelian randomization study |
| title_full_unstemmed | The associations between gut microbiota and inflammatory skin diseases: a bi-directional two-sample Mendelian randomization study |
| title_short | The associations between gut microbiota and inflammatory skin diseases: a bi-directional two-sample Mendelian randomization study |
| title_sort | associations between gut microbiota and inflammatory skin diseases a bi directional two sample mendelian randomization study |
| topic | atopic dermatitis gut microbiota Mendelian randomization psoriasis rosacea |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1297240/full |
| work_keys_str_mv | AT yunzhong theassociationsbetweengutmicrobiotaandinflammatoryskindiseasesabidirectionaltwosamplemendelianrandomizationstudy AT yunzhong theassociationsbetweengutmicrobiotaandinflammatoryskindiseasesabidirectionaltwosamplemendelianrandomizationstudy AT fanwang theassociationsbetweengutmicrobiotaandinflammatoryskindiseasesabidirectionaltwosamplemendelianrandomizationstudy AT xinmeng theassociationsbetweengutmicrobiotaandinflammatoryskindiseasesabidirectionaltwosamplemendelianrandomizationstudy AT leizhou theassociationsbetweengutmicrobiotaandinflammatoryskindiseasesabidirectionaltwosamplemendelianrandomizationstudy AT yunzhong associationsbetweengutmicrobiotaandinflammatoryskindiseasesabidirectionaltwosamplemendelianrandomizationstudy AT yunzhong associationsbetweengutmicrobiotaandinflammatoryskindiseasesabidirectionaltwosamplemendelianrandomizationstudy AT fanwang associationsbetweengutmicrobiotaandinflammatoryskindiseasesabidirectionaltwosamplemendelianrandomizationstudy AT xinmeng associationsbetweengutmicrobiotaandinflammatoryskindiseasesabidirectionaltwosamplemendelianrandomizationstudy AT leizhou associationsbetweengutmicrobiotaandinflammatoryskindiseasesabidirectionaltwosamplemendelianrandomizationstudy |