Alterations in thiol redox state and lipid peroxidation in the brain areas of male mice during aging
Aging is a natural process in organisms with its underlying mechanisms remaining unknown. Brain aging is accompanied by cognitive deficits and movement disorders, which signify the importance of elaborating its main mechanisms. In this study, oxidative stress biomarkers for lipid peroxidation and th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Advances in Redox Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667137922000157 |
| _version_ | 1828287628327256064 |
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| author | Konstantinos Grintzalis Nikolaos Patsoukis Ioannis Papapostolou George Zervoudakis Electra Kalaitzopoulou Christos D. Georgiou Nikolaos A. Matsokis Nikolaos T. Panagopoulos |
| author_facet | Konstantinos Grintzalis Nikolaos Patsoukis Ioannis Papapostolou George Zervoudakis Electra Kalaitzopoulou Christos D. Georgiou Nikolaos A. Matsokis Nikolaos T. Panagopoulos |
| author_sort | Konstantinos Grintzalis |
| collection | DOAJ |
| description | Aging is a natural process in organisms with its underlying mechanisms remaining unknown. Brain aging is accompanied by cognitive deficits and movement disorders, which signify the importance of elaborating its main mechanisms. In this study, oxidative stress biomarkers for lipid peroxidation and thiol redox state were assessed in different brain areas in male mice, categorised in respect to aging as young (three months), middle (eleven months) and elder aged (twenty-three months). Senescence was associated with an increase of lipid peroxidation and a decrease of reduced and oxidized glutathione. In some brain areas, reduced cysteine and oxidized protein thiols were increased with aging. Results support the theory that aging is associated with oxidative stress in the brain of mice and provide an insight in the biochemical aspect of aging in reference to thiol redox status as a potential marker for aging. |
| first_indexed | 2024-04-13T09:50:57Z |
| format | Article |
| id | doaj.art-4f575b7c525b4e839f8ce4c473e18bd8 |
| institution | Directory Open Access Journal |
| issn | 2667-1379 |
| language | English |
| last_indexed | 2024-04-13T09:50:57Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Redox Research |
| spelling | doaj.art-4f575b7c525b4e839f8ce4c473e18bd82022-12-22T02:51:35ZengElsevierAdvances in Redox Research2667-13792022-12-016100043Alterations in thiol redox state and lipid peroxidation in the brain areas of male mice during agingKonstantinos Grintzalis0Nikolaos Patsoukis1Ioannis Papapostolou2George Zervoudakis3Electra Kalaitzopoulou4Christos D. Georgiou5Nikolaos A. Matsokis6Nikolaos T. Panagopoulos7School of Biotechnology, Dublin City University, Dublin, Ireland; Laboratory of Biochemistry, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, Patras, Greece; Corresponding author: Dublin City University, School of Biotechnology, Glasnevin campus, Lonsdale Building, Office X224, D09 Y5NO, Dublin, Ireland.Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USALaboratory of Biochemistry, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, Patras, GreeceDepartment of Agriculture, University of Patras, GreeceLaboratory of Biochemistry, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, Patras, GreeceLaboratory of Biochemistry, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, Patras, GreeceLaboratory of Human and Animal Physiology, Section of Animal Biology, Faculty of Sciences, Department of Biology, University of Patras, Patras, GreeceLaboratory of Human and Animal Physiology, Section of Animal Biology, Faculty of Sciences, Department of Biology, University of Patras, Patras, GreeceAging is a natural process in organisms with its underlying mechanisms remaining unknown. Brain aging is accompanied by cognitive deficits and movement disorders, which signify the importance of elaborating its main mechanisms. In this study, oxidative stress biomarkers for lipid peroxidation and thiol redox state were assessed in different brain areas in male mice, categorised in respect to aging as young (three months), middle (eleven months) and elder aged (twenty-three months). Senescence was associated with an increase of lipid peroxidation and a decrease of reduced and oxidized glutathione. In some brain areas, reduced cysteine and oxidized protein thiols were increased with aging. Results support the theory that aging is associated with oxidative stress in the brain of mice and provide an insight in the biochemical aspect of aging in reference to thiol redox status as a potential marker for aging.http://www.sciencedirect.com/science/article/pii/S2667137922000157GlutathioneCysteineProtein thiolsLipid peroxidationOxidative stressBrain aging |
| spellingShingle | Konstantinos Grintzalis Nikolaos Patsoukis Ioannis Papapostolou George Zervoudakis Electra Kalaitzopoulou Christos D. Georgiou Nikolaos A. Matsokis Nikolaos T. Panagopoulos Alterations in thiol redox state and lipid peroxidation in the brain areas of male mice during aging Advances in Redox Research Glutathione Cysteine Protein thiols Lipid peroxidation Oxidative stress Brain aging |
| title | Alterations in thiol redox state and lipid peroxidation in the brain areas of male mice during aging |
| title_full | Alterations in thiol redox state and lipid peroxidation in the brain areas of male mice during aging |
| title_fullStr | Alterations in thiol redox state and lipid peroxidation in the brain areas of male mice during aging |
| title_full_unstemmed | Alterations in thiol redox state and lipid peroxidation in the brain areas of male mice during aging |
| title_short | Alterations in thiol redox state and lipid peroxidation in the brain areas of male mice during aging |
| title_sort | alterations in thiol redox state and lipid peroxidation in the brain areas of male mice during aging |
| topic | Glutathione Cysteine Protein thiols Lipid peroxidation Oxidative stress Brain aging |
| url | http://www.sciencedirect.com/science/article/pii/S2667137922000157 |
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