Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes
The cellular composition of previous engineered heart tissue is often heterogeneous. Here, the authors create chamber-specific human pluripotent stem cell-derived cardiomyocytes to form both ventricular and atrial cells before embedding in collagen-based matrix to form ring-shaped engineered heart t...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13868-x |
| _version_ | 1818835059707215872 |
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| author | Idit Goldfracht Stephanie Protze Assad Shiti Noga Setter Amit Gruber Naim Shaheen Yulia Nartiss Gordon Keller Lior Gepstein |
| author_facet | Idit Goldfracht Stephanie Protze Assad Shiti Noga Setter Amit Gruber Naim Shaheen Yulia Nartiss Gordon Keller Lior Gepstein |
| author_sort | Idit Goldfracht |
| collection | DOAJ |
| description | The cellular composition of previous engineered heart tissue is often heterogeneous. Here, the authors create chamber-specific human pluripotent stem cell-derived cardiomyocytes to form both ventricular and atrial cells before embedding in collagen-based matrix to form ring-shaped engineered heart tissue. |
| first_indexed | 2024-12-19T02:44:42Z |
| format | Article |
| id | doaj.art-4f5787cf0b7f4b91911fe4781075ae85 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T02:44:42Z |
| publishDate | 2020-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4f5787cf0b7f4b91911fe4781075ae852022-12-21T20:38:58ZengNature PortfolioNature Communications2041-17232020-01-0111111510.1038/s41467-019-13868-xGenerating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytesIdit Goldfracht0Stephanie Protze1Assad Shiti2Noga Setter3Amit Gruber4Naim Shaheen5Yulia Nartiss6Gordon Keller7Lior Gepstein8Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion‒Israel Institute of Technology, Haifa, Israel, POB 9649McEwen Stem Cell Institute, University Health NetworkSohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion‒Israel Institute of Technology, Haifa, Israel, POB 9649Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion‒Israel Institute of Technology, Haifa, Israel, POB 9649Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion‒Israel Institute of Technology, Haifa, Israel, POB 9649Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion‒Israel Institute of Technology, Haifa, Israel, POB 9649McEwen Stem Cell Institute, University Health NetworkMcEwen Stem Cell Institute, University Health NetworkSohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion‒Israel Institute of Technology, Haifa, Israel, POB 9649The cellular composition of previous engineered heart tissue is often heterogeneous. Here, the authors create chamber-specific human pluripotent stem cell-derived cardiomyocytes to form both ventricular and atrial cells before embedding in collagen-based matrix to form ring-shaped engineered heart tissue.https://doi.org/10.1038/s41467-019-13868-x |
| spellingShingle | Idit Goldfracht Stephanie Protze Assad Shiti Noga Setter Amit Gruber Naim Shaheen Yulia Nartiss Gordon Keller Lior Gepstein Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes Nature Communications |
| title | Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes |
| title_full | Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes |
| title_fullStr | Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes |
| title_full_unstemmed | Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes |
| title_short | Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes |
| title_sort | generating ring shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell derived cardiomyocytes |
| url | https://doi.org/10.1038/s41467-019-13868-x |
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