Non‐classical monocytes frequency and serum vitamin D3 levels are linked to diabetic foot ulcer associated with peripheral artery disease
Abstract Aims/Introduction Peripheral artery disease (PAD) serves as a risk factor for diabetic foot ulcers (DFUs). PAD pathology involves atherosclerosis and impaired immunity. Non‐classical monocytes are believed to have an anti‐inflammatory role. 1,25‐Dihydroxy vitamin D (vitamin D3) is claimed t...
Main Authors: | , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
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Wiley
2023-10-01
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Series: | Journal of Diabetes Investigation |
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Online Access: | https://doi.org/10.1111/jdi.14048 |
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author | Reham Hammad Maisa A Abdel Wahab Nehal Farouk Mohamed Yahia Zakaria Mona A Eldosoky Asmaa A Elmadbouly Sara A Tahoun Eman Mahmoud Seham K Khirala Amena Rezk Mohammed Wafaa Abdelaziz Emam Asmaa A Abo Elqasem Fatma M Kotb Rasha Abd Elaziz Abd Elghany |
author_facet | Reham Hammad Maisa A Abdel Wahab Nehal Farouk Mohamed Yahia Zakaria Mona A Eldosoky Asmaa A Elmadbouly Sara A Tahoun Eman Mahmoud Seham K Khirala Amena Rezk Mohammed Wafaa Abdelaziz Emam Asmaa A Abo Elqasem Fatma M Kotb Rasha Abd Elaziz Abd Elghany |
author_sort | Reham Hammad |
collection | DOAJ |
description | Abstract Aims/Introduction Peripheral artery disease (PAD) serves as a risk factor for diabetic foot ulcers (DFUs). PAD pathology involves atherosclerosis and impaired immunity. Non‐classical monocytes are believed to have an anti‐inflammatory role. 1,25‐Dihydroxy vitamin D (vitamin D3) is claimed to have immune‐modulating and lipid‐regulating roles. Vitamin D receptor is expressed on monocytes. We aimed to investigate if circulating non‐classical monocytes and vitamin D3 were implicated in DFUs associated with PAD. Materials and Methods There were two groups of DFU patients: group 1 (n = 40) included patients with first‐degree DFUs not associated with PAD, and group 2 (n = 50) included patients with DFU with PAD. The monocyte phenotypes were detected using flow cytometry. Vitamin D3 was assessed by enzyme‐linked immunosorbent assay. Results DFU patients with PAD showed a significant reduction in the frequency of non‐classical monocytes and vitamin D3 levels, when compared with DFU patients without PAD. The percentage of non‐classical monocytes positively correlated with vitamin D3 level (r = 0.4, P < 0.01) and high‐density lipoprotein (r = 0.5, P < 0.001), whereas it was negatively correlated with cholesterol (r = −0.5, P < 0.001). Vitamin D3 was negatively correlated with triglyceride/high‐density lipoprotein (r = −0.4, P < 0.01). Regression analysis showed that a high vitamin D3 serum level was a protective factor against PAD occurrence. Conclusions Non‐classical monocytes frequency and vitamin D3 levels were significantly reduced in DFU patients with PAD. Non‐classical monocytes frequency was associated with vitamin D3 in DFUs patients, and both parameters were linked to lipid profile. Vitamin D3 upregulation was a risk‐reducing factor for PAD occurrence. |
first_indexed | 2024-03-11T23:04:55Z |
format | Article |
id | doaj.art-4f5790792d6b455f9739d71ceb69d216 |
institution | Directory Open Access Journal |
issn | 2040-1116 2040-1124 |
language | English |
last_indexed | 2024-03-11T23:04:55Z |
publishDate | 2023-10-01 |
publisher | Wiley |
record_format | Article |
series | Journal of Diabetes Investigation |
spelling | doaj.art-4f5790792d6b455f9739d71ceb69d2162023-09-21T13:33:24ZengWileyJournal of Diabetes Investigation2040-11162040-11242023-10-0114101192120110.1111/jdi.14048Non‐classical monocytes frequency and serum vitamin D3 levels are linked to diabetic foot ulcer associated with peripheral artery diseaseReham Hammad0Maisa A Abdel Wahab1Nehal Farouk2Mohamed Yahia Zakaria3Mona A Eldosoky4Asmaa A Elmadbouly5Sara A Tahoun6Eman Mahmoud7Seham K Khirala8Amena Rezk Mohammed9Wafaa Abdelaziz Emam10Asmaa A Abo Elqasem11Fatma M Kotb12Rasha Abd Elaziz Abd Elghany13Clinical Pathology Department, Faculty of Medicine (for Girls) Al‐Azhar University Cairo EgyptVascular Surgery, Faculty of Medicine (for Girls) Al‐Azhar University Cairo EgyptVascular Surgery, Faculty of Medicine (for Girls) Al‐Azhar University Cairo EgyptVascular Surgery, Faculty of Medicine (for Boys) Al‐Azhar University Cairo EgyptClinical Pathology Department, Faculty of Medicine (for Girls) Al‐Azhar University Cairo EgyptClinical Pathology Department, Faculty of Medicine (for Girls) Al‐Azhar University Cairo EgyptClinical Pathology Department, Faculty of Medicine (for Girls) Al‐Azhar University Cairo EgyptEndocrinology and Metabolism Department, Faculty of Medicine (for Girls) Al‐Azhar University Cairo EgyptMedical Microbiology and Immunology, Faculty of Medicine (for Girls) Al‐Azhar University Cairo EgyptBiochemistry Department, Faculty of Medicine (for Girls) Al‐Azhar University Cairo EgyptBiochemistry Department, Faculty of Medicine (for Girls) Al‐Azhar University Cairo EgyptImmunology, Zoology and Entomology Department, Faculty of Science (for Girls) Al‐Azhar University Cairo EgyptInternal Medicine Department, Faculty of Medicine (Girls) Al‐Azhar University Cairo EgyptGeneral Surgery Department, Faculty of Medicine (for Girls) Al‐Azhar University Cairo EgyptAbstract Aims/Introduction Peripheral artery disease (PAD) serves as a risk factor for diabetic foot ulcers (DFUs). PAD pathology involves atherosclerosis and impaired immunity. Non‐classical monocytes are believed to have an anti‐inflammatory role. 1,25‐Dihydroxy vitamin D (vitamin D3) is claimed to have immune‐modulating and lipid‐regulating roles. Vitamin D receptor is expressed on monocytes. We aimed to investigate if circulating non‐classical monocytes and vitamin D3 were implicated in DFUs associated with PAD. Materials and Methods There were two groups of DFU patients: group 1 (n = 40) included patients with first‐degree DFUs not associated with PAD, and group 2 (n = 50) included patients with DFU with PAD. The monocyte phenotypes were detected using flow cytometry. Vitamin D3 was assessed by enzyme‐linked immunosorbent assay. Results DFU patients with PAD showed a significant reduction in the frequency of non‐classical monocytes and vitamin D3 levels, when compared with DFU patients without PAD. The percentage of non‐classical monocytes positively correlated with vitamin D3 level (r = 0.4, P < 0.01) and high‐density lipoprotein (r = 0.5, P < 0.001), whereas it was negatively correlated with cholesterol (r = −0.5, P < 0.001). Vitamin D3 was negatively correlated with triglyceride/high‐density lipoprotein (r = −0.4, P < 0.01). Regression analysis showed that a high vitamin D3 serum level was a protective factor against PAD occurrence. Conclusions Non‐classical monocytes frequency and vitamin D3 levels were significantly reduced in DFU patients with PAD. Non‐classical monocytes frequency was associated with vitamin D3 in DFUs patients, and both parameters were linked to lipid profile. Vitamin D3 upregulation was a risk‐reducing factor for PAD occurrence.https://doi.org/10.1111/jdi.14048Diabetic foot ulcerMonocyte subsetsVitamin D3 |
spellingShingle | Reham Hammad Maisa A Abdel Wahab Nehal Farouk Mohamed Yahia Zakaria Mona A Eldosoky Asmaa A Elmadbouly Sara A Tahoun Eman Mahmoud Seham K Khirala Amena Rezk Mohammed Wafaa Abdelaziz Emam Asmaa A Abo Elqasem Fatma M Kotb Rasha Abd Elaziz Abd Elghany Non‐classical monocytes frequency and serum vitamin D3 levels are linked to diabetic foot ulcer associated with peripheral artery disease Journal of Diabetes Investigation Diabetic foot ulcer Monocyte subsets Vitamin D3 |
title | Non‐classical monocytes frequency and serum vitamin D3 levels are linked to diabetic foot ulcer associated with peripheral artery disease |
title_full | Non‐classical monocytes frequency and serum vitamin D3 levels are linked to diabetic foot ulcer associated with peripheral artery disease |
title_fullStr | Non‐classical monocytes frequency and serum vitamin D3 levels are linked to diabetic foot ulcer associated with peripheral artery disease |
title_full_unstemmed | Non‐classical monocytes frequency and serum vitamin D3 levels are linked to diabetic foot ulcer associated with peripheral artery disease |
title_short | Non‐classical monocytes frequency and serum vitamin D3 levels are linked to diabetic foot ulcer associated with peripheral artery disease |
title_sort | non classical monocytes frequency and serum vitamin d3 levels are linked to diabetic foot ulcer associated with peripheral artery disease |
topic | Diabetic foot ulcer Monocyte subsets Vitamin D3 |
url | https://doi.org/10.1111/jdi.14048 |
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