Chemokine expression in patients with ovarian cancer or benign ovarian tumors
Introduction Chemokines play a crucial role in tumor growth and progression according to proangiogenic and immunosuppressive action. The aim of this study was to investigate the serum levels of selected chemokines in patients with ovarian cancer or benign ovarian tumors to assess their role in tumor...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2021-03-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/Chemokine-expression-in-patients-with-ovarian-cancer-or-benign-ovarian-tumors,110672,0,2.html |
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| author | Marek Nowak Łukasz Janas Malwina Soja Ewa Głowacka Krzysztof Szyłło Marcin Misiek Magdalena Klink |
| author_facet | Marek Nowak Łukasz Janas Malwina Soja Ewa Głowacka Krzysztof Szyłło Marcin Misiek Magdalena Klink |
| author_sort | Marek Nowak |
| collection | DOAJ |
| description | Introduction
Chemokines play a crucial role in tumor growth and progression according to proangiogenic and immunosuppressive action. The aim of this study was to investigate the serum levels of selected chemokines in patients with ovarian cancer or benign ovarian tumors to assess their role in tumorigenesis and their potential use in preoperative diagnosis of an adnexal mass.
Material and methods
The study group consisted of 59 women with ovarian cancer: 17 epithelial ovarian cancer (EOC) patients and 42 women with benign ovarian tumors. We measured in sera obtained preoperatively the level of CA125 and a panel of 5 chemokines – CX3CL1/fractalkine, CXCL1/GRO-α, CXCL12/SDF-1, CCL20/MIP-3α and IL-17F – using the chemiluminescence method with multiplexed bead based immunoassay.
Results
CX3CL1 was significantly elevated in sera of advanced ovarian cancer patients compared to women with benign ovarian tumors. The significant elevation of CXCL1 was also observed (both early and advanced stages). A similar pattern was present with the standard ovarian cancer marker CA125. In our patients with endometriotic cysts CA125 levels were significantly higher than in women with other benign tumors, whereas all analyzed chemokines had similar serum titers in patients with endometriotic vs. other benign ovarian cysts.
Conclusions
CX3CL1 and CXCL1 are elevated in sera of EOC patients, which indicates their role in cancer development. Moreover, they might be useful in preoperative differential diagnosis of ovarian tumors, especially as they were not elevated in cases of endometriosis. |
| first_indexed | 2024-04-12T16:40:21Z |
| format | Article |
| id | doaj.art-4f590c300e974ef9a545f4a0b117fea8 |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-04-12T16:40:21Z |
| publishDate | 2021-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-4f590c300e974ef9a545f4a0b117fea82022-12-22T03:24:50ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512021-03-0118368268910.5114/aoms/110672110672Chemokine expression in patients with ovarian cancer or benign ovarian tumorsMarek Nowak0Łukasz Janas1Malwina Soja2Ewa Głowacka3Krzysztof Szyłło4Marcin Misiek5Magdalena Klink6Department of Operative Gynecology and Gynecologic Oncology, Polish Mother’s Memorial Hospital – Research Institute, Lodz, PolandDepartment of Operative Gynecology and Gynecologic Oncology, Polish Mother’s Memorial Hospital – Research Institute, Lodz, PolandDepartment of Operative Gynecology and Gynecologic Oncology, Polish Mother’s Memorial Hospital – Research Institute, Lodz, PolandLaboratory Diagnostics Centre, Polish Mother’s Memorial Hospital – Research Institute, Lodz, PolandDepartment of Operative Gynecology and Gynecologic Oncology, Polish Mother’s Memorial Hospital – Research Institute, Lodz, PolandDepartment of Gynecology, Holy Cross Cancer Centre, Kielce, PolandInstitute of Medical Biology, Polish Academy of Sciences, Lodz, PolandIntroduction Chemokines play a crucial role in tumor growth and progression according to proangiogenic and immunosuppressive action. The aim of this study was to investigate the serum levels of selected chemokines in patients with ovarian cancer or benign ovarian tumors to assess their role in tumorigenesis and their potential use in preoperative diagnosis of an adnexal mass. Material and methods The study group consisted of 59 women with ovarian cancer: 17 epithelial ovarian cancer (EOC) patients and 42 women with benign ovarian tumors. We measured in sera obtained preoperatively the level of CA125 and a panel of 5 chemokines – CX3CL1/fractalkine, CXCL1/GRO-α, CXCL12/SDF-1, CCL20/MIP-3α and IL-17F – using the chemiluminescence method with multiplexed bead based immunoassay. Results CX3CL1 was significantly elevated in sera of advanced ovarian cancer patients compared to women with benign ovarian tumors. The significant elevation of CXCL1 was also observed (both early and advanced stages). A similar pattern was present with the standard ovarian cancer marker CA125. In our patients with endometriotic cysts CA125 levels were significantly higher than in women with other benign tumors, whereas all analyzed chemokines had similar serum titers in patients with endometriotic vs. other benign ovarian cysts. Conclusions CX3CL1 and CXCL1 are elevated in sera of EOC patients, which indicates their role in cancer development. Moreover, they might be useful in preoperative differential diagnosis of ovarian tumors, especially as they were not elevated in cases of endometriosis.https://www.archivesofmedicalscience.com/Chemokine-expression-in-patients-with-ovarian-cancer-or-benign-ovarian-tumors,110672,0,2.htmlovarian cancerendometriosiscx3cl1cxcl1 |
| spellingShingle | Marek Nowak Łukasz Janas Malwina Soja Ewa Głowacka Krzysztof Szyłło Marcin Misiek Magdalena Klink Chemokine expression in patients with ovarian cancer or benign ovarian tumors Archives of Medical Science ovarian cancer endometriosis cx3cl1 cxcl1 |
| title | Chemokine expression in patients with ovarian cancer or benign ovarian tumors |
| title_full | Chemokine expression in patients with ovarian cancer or benign ovarian tumors |
| title_fullStr | Chemokine expression in patients with ovarian cancer or benign ovarian tumors |
| title_full_unstemmed | Chemokine expression in patients with ovarian cancer or benign ovarian tumors |
| title_short | Chemokine expression in patients with ovarian cancer or benign ovarian tumors |
| title_sort | chemokine expression in patients with ovarian cancer or benign ovarian tumors |
| topic | ovarian cancer endometriosis cx3cl1 cxcl1 |
| url | https://www.archivesofmedicalscience.com/Chemokine-expression-in-patients-with-ovarian-cancer-or-benign-ovarian-tumors,110672,0,2.html |
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