LINC01134: a pivotal oncogene with promising predictive maker and therapeutic target in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) represents a leading and fatal malignancy within the gastrointestinal tract. Recent advancements highlight the pivotal role of long non-coding RNAs (lncRNAs) in diverse biological pathways and pathologies, particularly in tumorigenesis. LINC01134, a particular lncRNA,...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-02-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1265762/full |
| _version_ | 1797301188106911744 |
|---|---|
| author | Yutian Yu Jialing Wang Qingfa Guo Hongliang Luo |
| author_facet | Yutian Yu Jialing Wang Qingfa Guo Hongliang Luo |
| author_sort | Yutian Yu |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) represents a leading and fatal malignancy within the gastrointestinal tract. Recent advancements highlight the pivotal role of long non-coding RNAs (lncRNAs) in diverse biological pathways and pathologies, particularly in tumorigenesis. LINC01134, a particular lncRNA, has attracted considerable attention due to its oncogenic potential in hepatoma. Current research underscores LINC01134’s potential in augmenting the onset and progression of HCC, with notable implications in drug resistance. This review comprehensively explores the molecular functions and regulatory mechanisms of LINC01134 in HCC, offering a fresh perspective for therapeutic interventions. By delving into LINC01134’s multifaceted roles, we aim to foster novel strategies in HCC management. |
| first_indexed | 2024-03-07T23:18:53Z |
| format | Article |
| id | doaj.art-4f5a68af001a44b28d9e63d19cba4191 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-07T23:18:53Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4f5a68af001a44b28d9e63d19cba41912024-02-21T09:20:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-02-011410.3389/fonc.2024.12657621265762LINC01134: a pivotal oncogene with promising predictive maker and therapeutic target in hepatocellular carcinomaYutian Yu0Jialing Wang1Qingfa Guo2Hongliang Luo3Department of Spleen and Stomach Diseases, Jiujiang Hospital of Traditional Chinese Medicine, Jiujiang, Jiangxi, ChinaDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaSecond Clinical Medical College, Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaHepatocellular carcinoma (HCC) represents a leading and fatal malignancy within the gastrointestinal tract. Recent advancements highlight the pivotal role of long non-coding RNAs (lncRNAs) in diverse biological pathways and pathologies, particularly in tumorigenesis. LINC01134, a particular lncRNA, has attracted considerable attention due to its oncogenic potential in hepatoma. Current research underscores LINC01134’s potential in augmenting the onset and progression of HCC, with notable implications in drug resistance. This review comprehensively explores the molecular functions and regulatory mechanisms of LINC01134 in HCC, offering a fresh perspective for therapeutic interventions. By delving into LINC01134’s multifaceted roles, we aim to foster novel strategies in HCC management.https://www.frontiersin.org/articles/10.3389/fonc.2024.1265762/fullhepatocellular carcinomaLINC01134tumorigenesistumor biomarkertherapeutic target |
| spellingShingle | Yutian Yu Jialing Wang Qingfa Guo Hongliang Luo LINC01134: a pivotal oncogene with promising predictive maker and therapeutic target in hepatocellular carcinoma Frontiers in Oncology hepatocellular carcinoma LINC01134 tumorigenesis tumor biomarker therapeutic target |
| title | LINC01134: a pivotal oncogene with promising predictive maker and therapeutic target in hepatocellular carcinoma |
| title_full | LINC01134: a pivotal oncogene with promising predictive maker and therapeutic target in hepatocellular carcinoma |
| title_fullStr | LINC01134: a pivotal oncogene with promising predictive maker and therapeutic target in hepatocellular carcinoma |
| title_full_unstemmed | LINC01134: a pivotal oncogene with promising predictive maker and therapeutic target in hepatocellular carcinoma |
| title_short | LINC01134: a pivotal oncogene with promising predictive maker and therapeutic target in hepatocellular carcinoma |
| title_sort | linc01134 a pivotal oncogene with promising predictive maker and therapeutic target in hepatocellular carcinoma |
| topic | hepatocellular carcinoma LINC01134 tumorigenesis tumor biomarker therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1265762/full |
| work_keys_str_mv | AT yutianyu linc01134apivotaloncogenewithpromisingpredictivemakerandtherapeutictargetinhepatocellularcarcinoma AT jialingwang linc01134apivotaloncogenewithpromisingpredictivemakerandtherapeutictargetinhepatocellularcarcinoma AT qingfaguo linc01134apivotaloncogenewithpromisingpredictivemakerandtherapeutictargetinhepatocellularcarcinoma AT hongliangluo linc01134apivotaloncogenewithpromisingpredictivemakerandtherapeutictargetinhepatocellularcarcinoma |