Effects of COVID-19 infection in patients with autoimmune pulmonary alveolar proteinosis: a single-center study
Abstract Background Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare interstitial lung disease. COVID-19 is associated with worse prognosis in previous lung diseases patients. But the prognosis of aPAP patients after infection with COVID-19 is unclear. In December 2022, China experienced a...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Orphanet Journal of Rare Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13023-023-02950-9 |
| _version_ | 1827764178346049536 |
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| author | Chuanxin Duan Wangji Zhou Miaoyan Zhang Chongsheng Cheng Wenshuai Xu Jinrong Dai Shuzhen Meng Keqi Chen Yang Zhao Song Liu Shao-Ting Wang Yanli Yang Kai-Feng Xu Xinlun Tian |
| author_facet | Chuanxin Duan Wangji Zhou Miaoyan Zhang Chongsheng Cheng Wenshuai Xu Jinrong Dai Shuzhen Meng Keqi Chen Yang Zhao Song Liu Shao-Ting Wang Yanli Yang Kai-Feng Xu Xinlun Tian |
| author_sort | Chuanxin Duan |
| collection | DOAJ |
| description | Abstract Background Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare interstitial lung disease. COVID-19 is associated with worse prognosis in previous lung diseases patients. But the prognosis of aPAP patients after infection with COVID-19 is unclear. In December 2022, China experienced a large-scale outbreak of Omicron variant of the SARS-CoV-2. In this study, we aim to explore the clinical outcomes of aPAP patients infected with COVID-19. Results A total of 39 aPAP patients were included in this study. 30.77% patients had a decrease in oxygen saturation after COVID-19 infection. We compared the two groups of patients with or without decreased oxygen saturation after COVID-19 infection and found that patients who had previous oxygen therapy (decreased oxygen saturation vs. non decreased oxygen saturation: 6/12 vs. 4/27, P = 0.043), with lower baseline arterial oxygen partial pressure (74.50 ± 13.61 mmHg vs. 86.49 ± 11.92 mmHg, P = 0.009), lower baseline DLCO/VA% [77.0 (74.3, 93.6) % vs. 89.5 (78.2, 97.4) %, P = 0.036], shorter baseline 6MWD [464 (406, 538) m vs. 532 (470, 575) m, P = 0.028], higher disease severity score (P = 0.017), were more likely to have decreased oxygen saturation after COVID-19 infection. Conclusion aPAP patients with poor baseline respiration have a higher probability of hypoxia after COVID-19 infection, but fatal events were rare. |
| first_indexed | 2024-03-11T11:01:01Z |
| format | Article |
| id | doaj.art-4f5aa18712f943bfa75523424edd226d |
| institution | Directory Open Access Journal |
| issn | 1750-1172 |
| language | English |
| last_indexed | 2024-03-11T11:01:01Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Orphanet Journal of Rare Diseases |
| spelling | doaj.art-4f5aa18712f943bfa75523424edd226d2023-11-12T12:29:57ZengBMCOrphanet Journal of Rare Diseases1750-11722023-11-011811810.1186/s13023-023-02950-9Effects of COVID-19 infection in patients with autoimmune pulmonary alveolar proteinosis: a single-center studyChuanxin Duan0Wangji Zhou1Miaoyan Zhang2Chongsheng Cheng3Wenshuai Xu4Jinrong Dai5Shuzhen Meng6Keqi Chen7Yang Zhao8Song Liu9Shao-Ting Wang10Yanli Yang11Kai-Feng Xu12Xinlun Tian13Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeCenter of Medical Research, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeAbstract Background Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare interstitial lung disease. COVID-19 is associated with worse prognosis in previous lung diseases patients. But the prognosis of aPAP patients after infection with COVID-19 is unclear. In December 2022, China experienced a large-scale outbreak of Omicron variant of the SARS-CoV-2. In this study, we aim to explore the clinical outcomes of aPAP patients infected with COVID-19. Results A total of 39 aPAP patients were included in this study. 30.77% patients had a decrease in oxygen saturation after COVID-19 infection. We compared the two groups of patients with or without decreased oxygen saturation after COVID-19 infection and found that patients who had previous oxygen therapy (decreased oxygen saturation vs. non decreased oxygen saturation: 6/12 vs. 4/27, P = 0.043), with lower baseline arterial oxygen partial pressure (74.50 ± 13.61 mmHg vs. 86.49 ± 11.92 mmHg, P = 0.009), lower baseline DLCO/VA% [77.0 (74.3, 93.6) % vs. 89.5 (78.2, 97.4) %, P = 0.036], shorter baseline 6MWD [464 (406, 538) m vs. 532 (470, 575) m, P = 0.028], higher disease severity score (P = 0.017), were more likely to have decreased oxygen saturation after COVID-19 infection. Conclusion aPAP patients with poor baseline respiration have a higher probability of hypoxia after COVID-19 infection, but fatal events were rare.https://doi.org/10.1186/s13023-023-02950-9Autoimmune pulmonary alveolar proteinosisCOVID-19Oxygen saturation |
| spellingShingle | Chuanxin Duan Wangji Zhou Miaoyan Zhang Chongsheng Cheng Wenshuai Xu Jinrong Dai Shuzhen Meng Keqi Chen Yang Zhao Song Liu Shao-Ting Wang Yanli Yang Kai-Feng Xu Xinlun Tian Effects of COVID-19 infection in patients with autoimmune pulmonary alveolar proteinosis: a single-center study Orphanet Journal of Rare Diseases Autoimmune pulmonary alveolar proteinosis COVID-19 Oxygen saturation |
| title | Effects of COVID-19 infection in patients with autoimmune pulmonary alveolar proteinosis: a single-center study |
| title_full | Effects of COVID-19 infection in patients with autoimmune pulmonary alveolar proteinosis: a single-center study |
| title_fullStr | Effects of COVID-19 infection in patients with autoimmune pulmonary alveolar proteinosis: a single-center study |
| title_full_unstemmed | Effects of COVID-19 infection in patients with autoimmune pulmonary alveolar proteinosis: a single-center study |
| title_short | Effects of COVID-19 infection in patients with autoimmune pulmonary alveolar proteinosis: a single-center study |
| title_sort | effects of covid 19 infection in patients with autoimmune pulmonary alveolar proteinosis a single center study |
| topic | Autoimmune pulmonary alveolar proteinosis COVID-19 Oxygen saturation |
| url | https://doi.org/10.1186/s13023-023-02950-9 |
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