Haemodynamic determinants of quality of life in chronic heart failure
Abstract Background Heart failure patients demonstrate reduced functional capacity, hemodynamic function, and quality of life (QOL) which are associated with high mortality and morbidity rate. The aim of the present study was to assess the relationship between functional capacity, hemodynamic respon...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-022-02829-w |
| _version_ | 1798036365750829056 |
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| author | Serlie Fatrin Nduka C. Okwose Kristian Bailey Lazar Velicki Dejana Popovic Arsen Ristic Petar M. Seferovic Guy A. MacGowan Djordje G. Jakovljevic |
| author_facet | Serlie Fatrin Nduka C. Okwose Kristian Bailey Lazar Velicki Dejana Popovic Arsen Ristic Petar M. Seferovic Guy A. MacGowan Djordje G. Jakovljevic |
| author_sort | Serlie Fatrin |
| collection | DOAJ |
| description | Abstract Background Heart failure patients demonstrate reduced functional capacity, hemodynamic function, and quality of life (QOL) which are associated with high mortality and morbidity rate. The aim of the present study was to assess the relationship between functional capacity, hemodynamic response to exercise and QOL in chronic heart failure. Methods A single-centre prospective study recruited 42 chronic heart failure patients (11 females, mean age 60 ± 10 years) with reduced left ventricular ejection fraction (LVEF = 23 ± 7%). All participants completed a maximal graded cardiopulmonary exercise test with non-invasive hemodynamic (bioreactance) monitoring. QOL was assessed using Minnesota Living with Heart Failure Questionnaire. Results The average value of QOL score was 40 ± 23. There was a significant negative relationship between the QOL and peak O2 consumption (r = − 0.50, p ≤ 0.01). No significant relationship between the QOL and selected exercise hemodynamic measures was found, including peak exercise cardiac power output (r = 0.15, p = 0.34), cardiac output (r = 0.22, p = 0.15), and mean arterial blood pressure (r = − 0.08, p = 0.60). Conclusion Peak O2 consumption, but not hemodynamic response to exercise, is a significant determinant of QOL in chronic heart failure patients. |
| first_indexed | 2024-04-11T21:11:51Z |
| format | Article |
| id | doaj.art-4f5abb7657424ec5976e49cbaba0a450 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-11T21:11:51Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-4f5abb7657424ec5976e49cbaba0a4502022-12-22T04:03:00ZengBMCBMC Cardiovascular Disorders1471-22612022-09-012211610.1186/s12872-022-02829-wHaemodynamic determinants of quality of life in chronic heart failureSerlie Fatrin0Nduka C. Okwose1Kristian Bailey2Lazar Velicki3Dejana Popovic4Arsen Ristic5Petar M. Seferovic6Guy A. MacGowan7Djordje G. Jakovljevic8Cardiovascular Research Theme, Translational and Clinical, and Biosciences Research Institutes, Medical School, Faculty of Medical Sciences, Newcastle UniversityCardiovascular Research Theme, Translational and Clinical, and Biosciences Research Institutes, Medical School, Faculty of Medical Sciences, Newcastle UniversityNewcastle upon Tyne Hospitals NHS Foundation TrustInstitute of Cardiovascular Diseases Vojvodina, University of Novi SadDepartment of Cardiology, Medical School, Clinical Centre of Serbia, University of BelgradeDepartment of Cardiology, Medical School, Clinical Centre of Serbia, University of BelgradeDepartment of Cardiology, Medical School, Clinical Centre of Serbia, University of BelgradeCardiovascular Research Theme, Translational and Clinical, and Biosciences Research Institutes, Medical School, Faculty of Medical Sciences, Newcastle UniversityCardiovascular Research Theme, Translational and Clinical, and Biosciences Research Institutes, Medical School, Faculty of Medical Sciences, Newcastle UniversityAbstract Background Heart failure patients demonstrate reduced functional capacity, hemodynamic function, and quality of life (QOL) which are associated with high mortality and morbidity rate. The aim of the present study was to assess the relationship between functional capacity, hemodynamic response to exercise and QOL in chronic heart failure. Methods A single-centre prospective study recruited 42 chronic heart failure patients (11 females, mean age 60 ± 10 years) with reduced left ventricular ejection fraction (LVEF = 23 ± 7%). All participants completed a maximal graded cardiopulmonary exercise test with non-invasive hemodynamic (bioreactance) monitoring. QOL was assessed using Minnesota Living with Heart Failure Questionnaire. Results The average value of QOL score was 40 ± 23. There was a significant negative relationship between the QOL and peak O2 consumption (r = − 0.50, p ≤ 0.01). No significant relationship between the QOL and selected exercise hemodynamic measures was found, including peak exercise cardiac power output (r = 0.15, p = 0.34), cardiac output (r = 0.22, p = 0.15), and mean arterial blood pressure (r = − 0.08, p = 0.60). Conclusion Peak O2 consumption, but not hemodynamic response to exercise, is a significant determinant of QOL in chronic heart failure patients.https://doi.org/10.1186/s12872-022-02829-wHeart failureQuality of lifeExercise haemodynamics |
| spellingShingle | Serlie Fatrin Nduka C. Okwose Kristian Bailey Lazar Velicki Dejana Popovic Arsen Ristic Petar M. Seferovic Guy A. MacGowan Djordje G. Jakovljevic Haemodynamic determinants of quality of life in chronic heart failure BMC Cardiovascular Disorders Heart failure Quality of life Exercise haemodynamics |
| title | Haemodynamic determinants of quality of life in chronic heart failure |
| title_full | Haemodynamic determinants of quality of life in chronic heart failure |
| title_fullStr | Haemodynamic determinants of quality of life in chronic heart failure |
| title_full_unstemmed | Haemodynamic determinants of quality of life in chronic heart failure |
| title_short | Haemodynamic determinants of quality of life in chronic heart failure |
| title_sort | haemodynamic determinants of quality of life in chronic heart failure |
| topic | Heart failure Quality of life Exercise haemodynamics |
| url | https://doi.org/10.1186/s12872-022-02829-w |
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