Different Effects of Intramedullary Injection of Mesenchymal Stem Cells During the Acute vs. Chronic Inflammatory Phase on Bone Healing in the Murine Continuous Polyethylene Particle Infusion Model

Different Effects of Intramedullary Injection of Mesenchymal Stem Cells During the Acute vs. Chronic Inflammatory Phase on Bone Healing in the Murine Continuous Polyethylene Particle Infusion Model

Chronic inflammation is a common feature in many diseases of different organ systems, including bone. However, there are few interventions to mitigate chronic inflammation and preserve host tissue. Previous in vitro studies demonstrated that preconditioning of mesenchymal stem cells (pMSCs) using li...

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Bibliographic Details
Main Authors: Takeshi Utsunomiya, Ning Zhang, Tzuhua Lin, Yusuke Kohno, Masaya Ueno, Masahiro Maruyama, Claire Rhee, Ejun Huang, Zhenyu Yao, Stuart B. Goodman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
inflammation
bone healing
macrophage
mesenchymal stem cell
osteolysis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.631063/full

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