A dual role for adeno-associated virus in human health
Abstract Adeno-associated virus (AAV) differs from most other viruses, as it requires the simultaneous presence of a helper virus for an active infection. Up to 80% of the human population is seropositive for AAV antibodies. AAV has been known to be a non-pathogenic virus and an inhibitor of carcino...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Virology Journal |
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| Online Access: | https://doi.org/10.1186/s12985-023-02196-8 |
| _version_ | 1797453875727302656 |
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| author | Natalia M Araujo |
| author_facet | Natalia M Araujo |
| author_sort | Natalia M Araujo |
| collection | DOAJ |
| description | Abstract Adeno-associated virus (AAV) differs from most other viruses, as it requires the simultaneous presence of a helper virus for an active infection. Up to 80% of the human population is seropositive for AAV antibodies. AAV has been known to be a non-pathogenic virus and an inhibitor of carcinogenesis caused by coinfecting viruses. However, the recent reports associating AAV infection with hepatocellular carcinoma development and the mysterious cases of acute severe hepatitis in children have challenged the idea that AAV is a harmless virus. Herein, we explore the usefulness of AAV in gene therapy and the importance of AAV as a protector or perpetrator in human carcinogenesis, ultimately reflecting on the dual role of AAV in human health. |
| first_indexed | 2024-03-09T15:29:11Z |
| format | Article |
| id | doaj.art-4f5dd3ea71cb4b10995cbbdf11443948 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-03-09T15:29:11Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-4f5dd3ea71cb4b10995cbbdf114439482023-11-26T12:20:33ZengBMCVirology Journal1743-422X2023-10-012011310.1186/s12985-023-02196-8A dual role for adeno-associated virus in human healthNatalia M Araujo0Laboratory of Molecular Virology and Parasitology, Oswaldo Cruz Institute, FIOCRUZAbstract Adeno-associated virus (AAV) differs from most other viruses, as it requires the simultaneous presence of a helper virus for an active infection. Up to 80% of the human population is seropositive for AAV antibodies. AAV has been known to be a non-pathogenic virus and an inhibitor of carcinogenesis caused by coinfecting viruses. However, the recent reports associating AAV infection with hepatocellular carcinoma development and the mysterious cases of acute severe hepatitis in children have challenged the idea that AAV is a harmless virus. Herein, we explore the usefulness of AAV in gene therapy and the importance of AAV as a protector or perpetrator in human carcinogenesis, ultimately reflecting on the dual role of AAV in human health.https://doi.org/10.1186/s12985-023-02196-8AAVHepatocellular carcinomaHepatitisChildrenGene therapy |
| spellingShingle | Natalia M Araujo A dual role for adeno-associated virus in human health Virology Journal AAV Hepatocellular carcinoma Hepatitis Children Gene therapy |
| title | A dual role for adeno-associated virus in human health |
| title_full | A dual role for adeno-associated virus in human health |
| title_fullStr | A dual role for adeno-associated virus in human health |
| title_full_unstemmed | A dual role for adeno-associated virus in human health |
| title_short | A dual role for adeno-associated virus in human health |
| title_sort | dual role for adeno associated virus in human health |
| topic | AAV Hepatocellular carcinoma Hepatitis Children Gene therapy |
| url | https://doi.org/10.1186/s12985-023-02196-8 |
| work_keys_str_mv | AT nataliamaraujo adualroleforadenoassociatedvirusinhumanhealth AT nataliamaraujo dualroleforadenoassociatedvirusinhumanhealth |