Lamina Associated Domains and Gene Regulation in Development and Cancer
The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization. Genomic regions contacting the NL are lamina associated domains (LADs), which contain thousands of genes that are lowl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/3/271 |
| _version_ | 1797724903788511232 |
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| author | Silke J. A. Lochs Samy Kefalopoulou Jop Kind |
| author_facet | Silke J. A. Lochs Samy Kefalopoulou Jop Kind |
| author_sort | Silke J. A. Lochs |
| collection | DOAJ |
| description | The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization. Genomic regions contacting the NL are lamina associated domains (LADs), which contain thousands of genes that are lowly transcribed, and enriched for repressive histone modifications. LADs are dynamic structures that shift spatial positioning in accordance with cell-type specific gene expression changes during differentiation and development. Furthermore, recent studies have linked the disruption of LADs and alterations in the epigenome with the onset of diseases such as cancer. Here we focus on the role of LADs and the NL in gene regulation during development and cancer. |
| first_indexed | 2024-03-12T10:23:37Z |
| format | Article |
| id | doaj.art-4f5df0dcb3874419afedbbd6fcaa4f73 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T10:23:37Z |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4f5df0dcb3874419afedbbd6fcaa4f732023-09-02T09:54:40ZengMDPI AGCells2073-44092019-03-018327110.3390/cells8030271cells8030271Lamina Associated Domains and Gene Regulation in Development and CancerSilke J. A. Lochs0Samy Kefalopoulou1Jop Kind2Oncode Institute, Hubrecht Institute–KNAW and University Medical Center Utrecht, 3584 Utrecht, The NetherlandsOncode Institute, Hubrecht Institute–KNAW and University Medical Center Utrecht, 3584 Utrecht, The NetherlandsOncode Institute, Hubrecht Institute–KNAW and University Medical Center Utrecht, 3584 Utrecht, The NetherlandsThe nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization. Genomic regions contacting the NL are lamina associated domains (LADs), which contain thousands of genes that are lowly transcribed, and enriched for repressive histone modifications. LADs are dynamic structures that shift spatial positioning in accordance with cell-type specific gene expression changes during differentiation and development. Furthermore, recent studies have linked the disruption of LADs and alterations in the epigenome with the onset of diseases such as cancer. Here we focus on the role of LADs and the NL in gene regulation during development and cancer.https://www.mdpi.com/2073-4409/8/3/271nuclear laminalamina associated domaingene regulationheterochromatinlaminDNA methylationdevelopmentcancersenescence |
| spellingShingle | Silke J. A. Lochs Samy Kefalopoulou Jop Kind Lamina Associated Domains and Gene Regulation in Development and Cancer Cells nuclear lamina lamina associated domain gene regulation heterochromatin lamin DNA methylation development cancer senescence |
| title | Lamina Associated Domains and Gene Regulation in Development and Cancer |
| title_full | Lamina Associated Domains and Gene Regulation in Development and Cancer |
| title_fullStr | Lamina Associated Domains and Gene Regulation in Development and Cancer |
| title_full_unstemmed | Lamina Associated Domains and Gene Regulation in Development and Cancer |
| title_short | Lamina Associated Domains and Gene Regulation in Development and Cancer |
| title_sort | lamina associated domains and gene regulation in development and cancer |
| topic | nuclear lamina lamina associated domain gene regulation heterochromatin lamin DNA methylation development cancer senescence |
| url | https://www.mdpi.com/2073-4409/8/3/271 |
| work_keys_str_mv | AT silkejalochs laminaassociateddomainsandgeneregulationindevelopmentandcancer AT samykefalopoulou laminaassociateddomainsandgeneregulationindevelopmentandcancer AT jopkind laminaassociateddomainsandgeneregulationindevelopmentandcancer |