Case report: Surgical treatment of a primary giant epithelioid hemangioendothelioma of the spine with total en-bloc spondylectomy
BackgroundEpithelioid hemangioendothelioma (EHE) is an extremely uncommon malignant neoplasm that originates from vascular endothelial or pre-endothelial cells. In this report, we present the case of patient who was diagnosed with a primary giant EHE of the spine and underwent treatment with total e...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1109643/full |
| _version_ | 1797629652055883776 |
|---|---|
| author | Wanbao Ge Yuan Qu Tingting Hou Jiayin Zhang Qiuju Li Lili Yang Lanqing Cao Jindong Li Shanyong Zhang |
| author_facet | Wanbao Ge Yuan Qu Tingting Hou Jiayin Zhang Qiuju Li Lili Yang Lanqing Cao Jindong Li Shanyong Zhang |
| author_sort | Wanbao Ge |
| collection | DOAJ |
| description | BackgroundEpithelioid hemangioendothelioma (EHE) is an extremely uncommon malignant neoplasm that originates from vascular endothelial or pre-endothelial cells. In this report, we present the case of patient who was diagnosed with a primary giant EHE of the spine and underwent treatment with total en-bloc spondylectomy (TES).Case presentationA 43-year-old male patient with a history of he presented to our hospital with chronic and progressive back pain. Physical examination revealed weakened sensation of acupuncture and touch on the left costal arch, while relatively normal neurological functions were preserved. Radiological examinations identified a giant destructive soft tissue lesion occupying the T8 vertebral region, with moderate destruction of the pedicle and lamina, as well as the 7th left rib. A preoperative biopsy of the 8th vertebra resulted in a diagnosis of epithelioid hemangioendothelioma(EHE). Postoperative immunohistochemical and pathological reports confirmed the presence of EHE in the left ribs and T8 ribs. The patient underwent resection of the 7th left rib and posterior pedicle screw fixation with 8 pairs of screws and a titanium mesh cage. Subsequently, thoracic en bloc spondylectomy was performed on the T8 vertebra. The patient did not receive radiation or chemotherapy following surgery. Over a period of 3 years, the patient remained free of disease and relapse.ConclusionThe use of transarterial embolization with spherical embolic agents (TES) has been demonstrated to be a safe, effective, and reliable treatment option for hepatic epithelioid hemangioendothelioma (EHE). Nevertheless, it is crucial to conduct long-term follow-up of this patient in order to assess their clinical outcome. |
| first_indexed | 2024-03-11T10:56:10Z |
| format | Article |
| id | doaj.art-4f5f5e5fe8574d638ca077acf6f2bb75 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-11T10:56:10Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4f5f5e5fe8574d638ca077acf6f2bb752023-11-13T06:38:27ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-03-011310.3389/fonc.2023.11096431109643Case report: Surgical treatment of a primary giant epithelioid hemangioendothelioma of the spine with total en-bloc spondylectomyWanbao Ge0Yuan Qu1Tingting Hou2Jiayin Zhang3Qiuju Li4Lili Yang5Lanqing Cao6Jindong Li7Shanyong Zhang8Department of Spine Surgery, Second Affiliated Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Spine Surgery, Second Affiliated Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Spine Surgery, Second Affiliated Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Spine Surgery, Second Affiliated Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Spine Surgery, Second Affiliated Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Spine Surgery, Second Affiliated Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Pathology, Second Affiliated Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Thoracic Surgery, Second Affiliated Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Spine Surgery, Second Affiliated Hospital of Jilin University, Changchun, Jilin, ChinaBackgroundEpithelioid hemangioendothelioma (EHE) is an extremely uncommon malignant neoplasm that originates from vascular endothelial or pre-endothelial cells. In this report, we present the case of patient who was diagnosed with a primary giant EHE of the spine and underwent treatment with total en-bloc spondylectomy (TES).Case presentationA 43-year-old male patient with a history of he presented to our hospital with chronic and progressive back pain. Physical examination revealed weakened sensation of acupuncture and touch on the left costal arch, while relatively normal neurological functions were preserved. Radiological examinations identified a giant destructive soft tissue lesion occupying the T8 vertebral region, with moderate destruction of the pedicle and lamina, as well as the 7th left rib. A preoperative biopsy of the 8th vertebra resulted in a diagnosis of epithelioid hemangioendothelioma(EHE). Postoperative immunohistochemical and pathological reports confirmed the presence of EHE in the left ribs and T8 ribs. The patient underwent resection of the 7th left rib and posterior pedicle screw fixation with 8 pairs of screws and a titanium mesh cage. Subsequently, thoracic en bloc spondylectomy was performed on the T8 vertebra. The patient did not receive radiation or chemotherapy following surgery. Over a period of 3 years, the patient remained free of disease and relapse.ConclusionThe use of transarterial embolization with spherical embolic agents (TES) has been demonstrated to be a safe, effective, and reliable treatment option for hepatic epithelioid hemangioendothelioma (EHE). Nevertheless, it is crucial to conduct long-term follow-up of this patient in order to assess their clinical outcome.https://www.frontiersin.org/articles/10.3389/fonc.2023.1109643/fullepithelioid hemangioendotheliomatotal en-bloc spondylectomyvertebral lesionvascular neoplasmgiant |
| spellingShingle | Wanbao Ge Yuan Qu Tingting Hou Jiayin Zhang Qiuju Li Lili Yang Lanqing Cao Jindong Li Shanyong Zhang Case report: Surgical treatment of a primary giant epithelioid hemangioendothelioma of the spine with total en-bloc spondylectomy Frontiers in Oncology epithelioid hemangioendothelioma total en-bloc spondylectomy vertebral lesion vascular neoplasm giant |
| title | Case report: Surgical treatment of a primary giant epithelioid hemangioendothelioma of the spine with total en-bloc spondylectomy |
| title_full | Case report: Surgical treatment of a primary giant epithelioid hemangioendothelioma of the spine with total en-bloc spondylectomy |
| title_fullStr | Case report: Surgical treatment of a primary giant epithelioid hemangioendothelioma of the spine with total en-bloc spondylectomy |
| title_full_unstemmed | Case report: Surgical treatment of a primary giant epithelioid hemangioendothelioma of the spine with total en-bloc spondylectomy |
| title_short | Case report: Surgical treatment of a primary giant epithelioid hemangioendothelioma of the spine with total en-bloc spondylectomy |
| title_sort | case report surgical treatment of a primary giant epithelioid hemangioendothelioma of the spine with total en bloc spondylectomy |
| topic | epithelioid hemangioendothelioma total en-bloc spondylectomy vertebral lesion vascular neoplasm giant |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1109643/full |
| work_keys_str_mv | AT wanbaoge casereportsurgicaltreatmentofaprimarygiantepithelioidhemangioendotheliomaofthespinewithtotalenblocspondylectomy AT yuanqu casereportsurgicaltreatmentofaprimarygiantepithelioidhemangioendotheliomaofthespinewithtotalenblocspondylectomy AT tingtinghou casereportsurgicaltreatmentofaprimarygiantepithelioidhemangioendotheliomaofthespinewithtotalenblocspondylectomy AT jiayinzhang casereportsurgicaltreatmentofaprimarygiantepithelioidhemangioendotheliomaofthespinewithtotalenblocspondylectomy AT qiujuli casereportsurgicaltreatmentofaprimarygiantepithelioidhemangioendotheliomaofthespinewithtotalenblocspondylectomy AT liliyang casereportsurgicaltreatmentofaprimarygiantepithelioidhemangioendotheliomaofthespinewithtotalenblocspondylectomy AT lanqingcao casereportsurgicaltreatmentofaprimarygiantepithelioidhemangioendotheliomaofthespinewithtotalenblocspondylectomy AT jindongli casereportsurgicaltreatmentofaprimarygiantepithelioidhemangioendotheliomaofthespinewithtotalenblocspondylectomy AT shanyongzhang casereportsurgicaltreatmentofaprimarygiantepithelioidhemangioendotheliomaofthespinewithtotalenblocspondylectomy |