Preventive Effect of <i>Arctium lappa</i> Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities
The objective of this study was to investigate the preventive effects of polysaccharides extracted from the roots of <i>Arctium lappa</i> (ALP) against acute lung injury (ALI) models induced by lipopolysaccharide (LPS). The polysaccharides were extracted and characterized, and their anti...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/15/23/4946 |
| _version_ | 1797399700752564224 |
|---|---|
| author | Naiyan Lu Jiayi Wei Xuelei Gong Xue Tang Xuan Zhang Wen Xiang Samuel Liu Cherry Luo Xun Wang |
| author_facet | Naiyan Lu Jiayi Wei Xuelei Gong Xue Tang Xuan Zhang Wen Xiang Samuel Liu Cherry Luo Xun Wang |
| author_sort | Naiyan Lu |
| collection | DOAJ |
| description | The objective of this study was to investigate the preventive effects of polysaccharides extracted from the roots of <i>Arctium lappa</i> (ALP) against acute lung injury (ALI) models induced by lipopolysaccharide (LPS). The polysaccharides were extracted and characterized, and their anti-inflammatory and antioxidant capacities were assessed. The findings demonstrated that ALP could mitigate the infiltration of inflammatory cells and reduce alveolar collapse in LPS-induced ALI in mice. The expression levels of the <i>pro</i>-inflammatory factor TNF-α decreased, while the anti-inflammatory factor IL-10 increased. Furthermore, the administration of ALP improved the activities of lung antioxidant enzymes, including SOD, GSH, and CAT, and lowered MDA levels. These results suggest that ALP exhibits a preventive effect on ALI and has potential as an alternative treatment for lung injury. |
| first_indexed | 2024-03-09T01:44:52Z |
| format | Article |
| id | doaj.art-4f603c21aaf0470bba36736488bbbd94 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T01:44:52Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-4f603c21aaf0470bba36736488bbbd942023-12-08T15:23:25ZengMDPI AGNutrients2072-66432023-11-011523494610.3390/nu15234946Preventive Effect of <i>Arctium lappa</i> Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant ActivitiesNaiyan Lu0Jiayi Wei1Xuelei Gong2Xue Tang3Xuan Zhang4Wen Xiang5Samuel Liu6Cherry Luo7Xun Wang8Department of Pulmonary and Critical Care Medicine, Jiangnan University Medical Center, Jiangnan University, Wuxi 214126, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi 214126, ChinaDepartment of Pulmonary and Critical Care Medicine, Jiangnan University Medical Center, Jiangnan University, Wuxi 214126, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi 214126, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi 214126, ChinaSchool of Medicine, Nankai University, Tianjin 300350, ChinaShenzhen Buddy Technology Development Co., Ltd., Shenzhen 518000, ChinaShenzhen Buddy Technology Development Co., Ltd., Shenzhen 518000, ChinaDepartment of Pulmonary and Critical Care Medicine, Jiangnan University Medical Center, Jiangnan University, Wuxi 214126, ChinaThe objective of this study was to investigate the preventive effects of polysaccharides extracted from the roots of <i>Arctium lappa</i> (ALP) against acute lung injury (ALI) models induced by lipopolysaccharide (LPS). The polysaccharides were extracted and characterized, and their anti-inflammatory and antioxidant capacities were assessed. The findings demonstrated that ALP could mitigate the infiltration of inflammatory cells and reduce alveolar collapse in LPS-induced ALI in mice. The expression levels of the <i>pro</i>-inflammatory factor TNF-α decreased, while the anti-inflammatory factor IL-10 increased. Furthermore, the administration of ALP improved the activities of lung antioxidant enzymes, including SOD, GSH, and CAT, and lowered MDA levels. These results suggest that ALP exhibits a preventive effect on ALI and has potential as an alternative treatment for lung injury.https://www.mdpi.com/2072-6643/15/23/4946<i>Arctium lappa</i>polysaccharidelung injuryLPSinflammation |
| spellingShingle | Naiyan Lu Jiayi Wei Xuelei Gong Xue Tang Xuan Zhang Wen Xiang Samuel Liu Cherry Luo Xun Wang Preventive Effect of <i>Arctium lappa</i> Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities Nutrients <i>Arctium lappa</i> polysaccharide lung injury LPS inflammation |
| title | Preventive Effect of <i>Arctium lappa</i> Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities |
| title_full | Preventive Effect of <i>Arctium lappa</i> Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities |
| title_fullStr | Preventive Effect of <i>Arctium lappa</i> Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities |
| title_full_unstemmed | Preventive Effect of <i>Arctium lappa</i> Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities |
| title_short | Preventive Effect of <i>Arctium lappa</i> Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities |
| title_sort | preventive effect of i arctium lappa i polysaccharides on acute lung injury through anti inflammatory and antioxidant activities |
| topic | <i>Arctium lappa</i> polysaccharide lung injury LPS inflammation |
| url | https://www.mdpi.com/2072-6643/15/23/4946 |
| work_keys_str_mv | AT naiyanlu preventiveeffectofiarctiumlappaipolysaccharidesonacutelunginjurythroughantiinflammatoryandantioxidantactivities AT jiayiwei preventiveeffectofiarctiumlappaipolysaccharidesonacutelunginjurythroughantiinflammatoryandantioxidantactivities AT xueleigong preventiveeffectofiarctiumlappaipolysaccharidesonacutelunginjurythroughantiinflammatoryandantioxidantactivities AT xuetang preventiveeffectofiarctiumlappaipolysaccharidesonacutelunginjurythroughantiinflammatoryandantioxidantactivities AT xuanzhang preventiveeffectofiarctiumlappaipolysaccharidesonacutelunginjurythroughantiinflammatoryandantioxidantactivities AT wenxiang preventiveeffectofiarctiumlappaipolysaccharidesonacutelunginjurythroughantiinflammatoryandantioxidantactivities AT samuelliu preventiveeffectofiarctiumlappaipolysaccharidesonacutelunginjurythroughantiinflammatoryandantioxidantactivities AT cherryluo preventiveeffectofiarctiumlappaipolysaccharidesonacutelunginjurythroughantiinflammatoryandantioxidantactivities AT xunwang preventiveeffectofiarctiumlappaipolysaccharidesonacutelunginjurythroughantiinflammatoryandantioxidantactivities |