Head-to-head comparison of ultrasound and 99mTc-glucosamine SPECT/CT imaging of patients with rheumatoid arthritis: a single center prospective study
Abstract Background Rheumatoid arthritis (RA) is an inflammatory disease that can lead to progressive joint damage. Early identification of synovitis is key in the management of patients with RA. The aim of this study was to assess synovitis in patients with RA using 99mTc-glucosamine single photon...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-12-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
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| Online Access: | https://doi.org/10.1186/s43055-023-01168-w |
| _version_ | 1797388467630505984 |
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| author | Osayande Evbuomwan Gerrit Engelbrecht Cathryn Driver Joseph Sempa Barend Jansen van Rensburg Mathys Labuschagne Je’nine Horn-Lodewyk |
| author_facet | Osayande Evbuomwan Gerrit Engelbrecht Cathryn Driver Joseph Sempa Barend Jansen van Rensburg Mathys Labuschagne Je’nine Horn-Lodewyk |
| author_sort | Osayande Evbuomwan |
| collection | DOAJ |
| description | Abstract Background Rheumatoid arthritis (RA) is an inflammatory disease that can lead to progressive joint damage. Early identification of synovitis is key in the management of patients with RA. The aim of this study was to assess synovitis in patients with RA using 99mTc-glucosamine single photon emission computed tomography/computed tomography (SPECT/CT) imaging and compare this radiopharmaceutical's diagnostic performance with ultrasound (US) imaging. This prospective study included 22 participants with active RA and 380 joints were assessed with SPECT/CT and US imaging. SPECT/CT imaging of the joints of interest was performed in each participant three hours after injection of 99mTc-glucosamine, with US imaging of the same joints performed on the same day. The affected joints were qualitatively assessed for 99mTc-glucosamine uptake and compared with the findings on US imaging. Results Abnormal increased uptake of 99mTc-glucosamine, localized specifically to the synovial space, was noted in the affected joints. The overall sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of 99mTc-glucosamine SPECT/CT imaging were 86%, 60%, 61%, 85% and 73%, respectively. A sensitivity of 100% was noted in the identification of synovitis in the carpal and knee joints. Disease activity in the distal interphalangeal (DIP) joints was not observed with either SPECT/CT or US. Conclusions SPECT/CT imaging with 99mTc-glucosamine is a valuable tool for assessing disease activity in the joints of patients with RA. It has a very high sensitivity in detecting synovitis and it correlates very well with US imaging in this regard. |
| first_indexed | 2024-03-08T22:40:17Z |
| format | Article |
| id | doaj.art-4f608da166a647379707e9886c480238 |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-03-08T22:40:17Z |
| publishDate | 2023-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-4f608da166a647379707e9886c4802382023-12-17T12:10:47ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622023-12-015411810.1186/s43055-023-01168-wHead-to-head comparison of ultrasound and 99mTc-glucosamine SPECT/CT imaging of patients with rheumatoid arthritis: a single center prospective studyOsayande Evbuomwan0Gerrit Engelbrecht1Cathryn Driver2Joseph Sempa3Barend Jansen van Rensburg4Mathys Labuschagne5Je’nine Horn-Lodewyk6Department of Nuclear Medicine, Faculty of Health Sciences, University of the Free StateDepartment of Nuclear Medicine, Faculty of Health Sciences, University of the Free StateDepartment of Radiochemistry, Nuclear Energy Corporation of South Africa (NECSA)Department of Biostatistics, University of the Free StateDepartment of Internal Medicine, Rheumatology Division, University of the Free StateFaculty of Health Sciences, University of the Free StateDepartment of Clinical Sciences, Faculty of Health and Environmental Sciences, Central University of Technology Free StateAbstract Background Rheumatoid arthritis (RA) is an inflammatory disease that can lead to progressive joint damage. Early identification of synovitis is key in the management of patients with RA. The aim of this study was to assess synovitis in patients with RA using 99mTc-glucosamine single photon emission computed tomography/computed tomography (SPECT/CT) imaging and compare this radiopharmaceutical's diagnostic performance with ultrasound (US) imaging. This prospective study included 22 participants with active RA and 380 joints were assessed with SPECT/CT and US imaging. SPECT/CT imaging of the joints of interest was performed in each participant three hours after injection of 99mTc-glucosamine, with US imaging of the same joints performed on the same day. The affected joints were qualitatively assessed for 99mTc-glucosamine uptake and compared with the findings on US imaging. Results Abnormal increased uptake of 99mTc-glucosamine, localized specifically to the synovial space, was noted in the affected joints. The overall sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of 99mTc-glucosamine SPECT/CT imaging were 86%, 60%, 61%, 85% and 73%, respectively. A sensitivity of 100% was noted in the identification of synovitis in the carpal and knee joints. Disease activity in the distal interphalangeal (DIP) joints was not observed with either SPECT/CT or US. Conclusions SPECT/CT imaging with 99mTc-glucosamine is a valuable tool for assessing disease activity in the joints of patients with RA. It has a very high sensitivity in detecting synovitis and it correlates very well with US imaging in this regard.https://doi.org/10.1186/s43055-023-01168-wRheumatoid arthritisDisease activitySynovitisUltrasound99mTc-glucosamineSPECT/CT |
| spellingShingle | Osayande Evbuomwan Gerrit Engelbrecht Cathryn Driver Joseph Sempa Barend Jansen van Rensburg Mathys Labuschagne Je’nine Horn-Lodewyk Head-to-head comparison of ultrasound and 99mTc-glucosamine SPECT/CT imaging of patients with rheumatoid arthritis: a single center prospective study The Egyptian Journal of Radiology and Nuclear Medicine Rheumatoid arthritis Disease activity Synovitis Ultrasound 99mTc-glucosamine SPECT/CT |
| title | Head-to-head comparison of ultrasound and 99mTc-glucosamine SPECT/CT imaging of patients with rheumatoid arthritis: a single center prospective study |
| title_full | Head-to-head comparison of ultrasound and 99mTc-glucosamine SPECT/CT imaging of patients with rheumatoid arthritis: a single center prospective study |
| title_fullStr | Head-to-head comparison of ultrasound and 99mTc-glucosamine SPECT/CT imaging of patients with rheumatoid arthritis: a single center prospective study |
| title_full_unstemmed | Head-to-head comparison of ultrasound and 99mTc-glucosamine SPECT/CT imaging of patients with rheumatoid arthritis: a single center prospective study |
| title_short | Head-to-head comparison of ultrasound and 99mTc-glucosamine SPECT/CT imaging of patients with rheumatoid arthritis: a single center prospective study |
| title_sort | head to head comparison of ultrasound and 99mtc glucosamine spect ct imaging of patients with rheumatoid arthritis a single center prospective study |
| topic | Rheumatoid arthritis Disease activity Synovitis Ultrasound 99mTc-glucosamine SPECT/CT |
| url | https://doi.org/10.1186/s43055-023-01168-w |
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