E-Cannula reveals anatomical diversity in sharp-wave ripples as a driver for the recruitment of distinct hippocampal assemblies
Summary: The hippocampus plays a critical role in spatial navigation and episodic memory. However, research on in vivo hippocampal activity dynamics mostly relies on single modalities, such as electrical recordings or optical imaging, with respectively limited spatial and temporal resolution. Here,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124722012943 |
| _version_ | 1798028331467145216 |
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| author | Xin Liu Satoshi Terada Mehrdad Ramezani Jeong-Hoon Kim Yichen Lu Andres Grosmark Attila Losonczy Duygu Kuzum |
| author_facet | Xin Liu Satoshi Terada Mehrdad Ramezani Jeong-Hoon Kim Yichen Lu Andres Grosmark Attila Losonczy Duygu Kuzum |
| author_sort | Xin Liu |
| collection | DOAJ |
| description | Summary: The hippocampus plays a critical role in spatial navigation and episodic memory. However, research on in vivo hippocampal activity dynamics mostly relies on single modalities, such as electrical recordings or optical imaging, with respectively limited spatial and temporal resolution. Here, we develop the E-Cannula, integrating fully transparent graphene microelectrodes with imaging cannula, which enables simultaneous electrical recording and two-photon calcium imaging from the exact same neural populations across an anatomically extended region of the mouse hippocampal CA1 stably across several days. The large-scale multimodal recordings show that sharp wave ripples (SWRs) exhibit spatiotemporal wave patterns along multiple axes in two-dimensional (2D) space with different spatial extents and temporal propagation modes. Notably, distinct SWR wave patterns are associated with the selective recruitment of orthogonal CA1 cell assemblies. These results demonstrate the utility of the E-Cannula as a versatile neurotechnology with the potential for future integration with other optical components. |
| first_indexed | 2024-04-11T19:06:11Z |
| format | Article |
| id | doaj.art-4f6141a9390348e9a345d90e7e4d141d |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-11T19:06:11Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-4f6141a9390348e9a345d90e7e4d141d2022-12-22T04:07:45ZengElsevierCell Reports2211-12472022-10-01411111453E-Cannula reveals anatomical diversity in sharp-wave ripples as a driver for the recruitment of distinct hippocampal assembliesXin Liu0Satoshi Terada1Mehrdad Ramezani2Jeong-Hoon Kim3Yichen Lu4Andres Grosmark5Attila Losonczy6Duygu Kuzum7Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA, USADepartment of Neuroscience, Columbia University, New York, NY, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USADepartment of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA, USADepartment of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA, USADepartment of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA, USADepartment of Neuroscience, Columbia University, New York, NY, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA; The Kavli Institute for Brain Science, Columbia University, New York, NY, USADepartment of Neuroscience, Columbia University, New York, NY, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA; The Kavli Institute for Brain Science, Columbia University, New York, NY, USA; Corresponding authorDepartment of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA, USA; Halıcıoğlu Data Science Institute, University of California, San Diego, La Jolla, CA, USA; Corresponding authorSummary: The hippocampus plays a critical role in spatial navigation and episodic memory. However, research on in vivo hippocampal activity dynamics mostly relies on single modalities, such as electrical recordings or optical imaging, with respectively limited spatial and temporal resolution. Here, we develop the E-Cannula, integrating fully transparent graphene microelectrodes with imaging cannula, which enables simultaneous electrical recording and two-photon calcium imaging from the exact same neural populations across an anatomically extended region of the mouse hippocampal CA1 stably across several days. The large-scale multimodal recordings show that sharp wave ripples (SWRs) exhibit spatiotemporal wave patterns along multiple axes in two-dimensional (2D) space with different spatial extents and temporal propagation modes. Notably, distinct SWR wave patterns are associated with the selective recruitment of orthogonal CA1 cell assemblies. These results demonstrate the utility of the E-Cannula as a versatile neurotechnology with the potential for future integration with other optical components.http://www.sciencedirect.com/science/article/pii/S2211124722012943CP: Neuroscience |
| spellingShingle | Xin Liu Satoshi Terada Mehrdad Ramezani Jeong-Hoon Kim Yichen Lu Andres Grosmark Attila Losonczy Duygu Kuzum E-Cannula reveals anatomical diversity in sharp-wave ripples as a driver for the recruitment of distinct hippocampal assemblies Cell Reports CP: Neuroscience |
| title | E-Cannula reveals anatomical diversity in sharp-wave ripples as a driver for the recruitment of distinct hippocampal assemblies |
| title_full | E-Cannula reveals anatomical diversity in sharp-wave ripples as a driver for the recruitment of distinct hippocampal assemblies |
| title_fullStr | E-Cannula reveals anatomical diversity in sharp-wave ripples as a driver for the recruitment of distinct hippocampal assemblies |
| title_full_unstemmed | E-Cannula reveals anatomical diversity in sharp-wave ripples as a driver for the recruitment of distinct hippocampal assemblies |
| title_short | E-Cannula reveals anatomical diversity in sharp-wave ripples as a driver for the recruitment of distinct hippocampal assemblies |
| title_sort | e cannula reveals anatomical diversity in sharp wave ripples as a driver for the recruitment of distinct hippocampal assemblies |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124722012943 |
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