Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene
ABSTRACTAlthough A-to-I RNA editing leads to similar effects to A-to-G DNA mutation, nonsynonymous RNA editing (recoding) is believed to confer its adaptiveness by ‘epigenetically’ regulating proteomic diversity in a temporospatial manner, avoiding the pleiotropic effect of genomic mutations. Recent...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Epigenetics |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15592294.2024.2333665 |
| _version_ | 1797246515849199616 |
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| author | Caiqing Zheng Ling Ma Fan Song Li Tian Wanzhi Cai Hu Li Yuange Duan |
| author_facet | Caiqing Zheng Ling Ma Fan Song Li Tian Wanzhi Cai Hu Li Yuange Duan |
| author_sort | Caiqing Zheng |
| collection | DOAJ |
| description | ABSTRACTAlthough A-to-I RNA editing leads to similar effects to A-to-G DNA mutation, nonsynonymous RNA editing (recoding) is believed to confer its adaptiveness by ‘epigenetically’ regulating proteomic diversity in a temporospatial manner, avoiding the pleiotropic effect of genomic mutations. Recent discoveries on the evolutionary trajectory of Ser>Gly auto-editing site in insect Adar gene demonstrated a selective advantage to having an editable codon compared to uneditable ones. However, apart from pure observations, quantitative approaches for justifying the adaptiveness of individual RNA editing sites are still lacking. We performed a comparative genomic analysis on 113 Diptera species, focusing on the Adar Ser>Gly auto-recoding site in Drosophila. We only found one species having a derived Gly at the corresponding site, and this occurrence was significantly lower than genome-wide random expectation. This suggests that the Adar Ser>Gly site is unlikely to be genomically replaced with G during evolution, and thus indicating the advantage of editable status over hardwired genomic alleles. Similar trends were observed for the conserved Ile>Met recoding in gene Syt1. In the light of evolution, we established a comparative genomic approach for quantitatively justifying the adaptiveness of individual editing sites. Priority should be given to such adaptive editing sites in future functional studies. |
| first_indexed | 2024-04-24T19:44:02Z |
| format | Article |
| id | doaj.art-4f62541ee74746aca6b2c23f44fab110 |
| institution | Directory Open Access Journal |
| issn | 1559-2294 1559-2308 |
| language | English |
| last_indexed | 2024-04-24T19:44:02Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj.art-4f62541ee74746aca6b2c23f44fab1102024-03-25T09:54:20ZengTaylor & Francis GroupEpigenetics1559-22941559-23082024-12-0119110.1080/15592294.2024.2333665Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar geneCaiqing Zheng0Ling Ma1Fan Song2Li Tian3Wanzhi Cai4Hu Li5Yuange Duan6Department of Entomology and MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing, ChinaDepartment of Entomology and MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing, ChinaDepartment of Entomology and MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing, ChinaDepartment of Entomology and MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing, ChinaDepartment of Entomology and MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing, ChinaDepartment of Entomology and MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing, ChinaDepartment of Entomology and MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing, ChinaABSTRACTAlthough A-to-I RNA editing leads to similar effects to A-to-G DNA mutation, nonsynonymous RNA editing (recoding) is believed to confer its adaptiveness by ‘epigenetically’ regulating proteomic diversity in a temporospatial manner, avoiding the pleiotropic effect of genomic mutations. Recent discoveries on the evolutionary trajectory of Ser>Gly auto-editing site in insect Adar gene demonstrated a selective advantage to having an editable codon compared to uneditable ones. However, apart from pure observations, quantitative approaches for justifying the adaptiveness of individual RNA editing sites are still lacking. We performed a comparative genomic analysis on 113 Diptera species, focusing on the Adar Ser>Gly auto-recoding site in Drosophila. We only found one species having a derived Gly at the corresponding site, and this occurrence was significantly lower than genome-wide random expectation. This suggests that the Adar Ser>Gly site is unlikely to be genomically replaced with G during evolution, and thus indicating the advantage of editable status over hardwired genomic alleles. Similar trends were observed for the conserved Ile>Met recoding in gene Syt1. In the light of evolution, we established a comparative genomic approach for quantitatively justifying the adaptiveness of individual editing sites. Priority should be given to such adaptive editing sites in future functional studies.https://www.tandfonline.com/doi/10.1080/15592294.2024.2333665A-to-I RNA editingAdarSer>Gly auto-recodinginsectDrosophilaadaptive |
| spellingShingle | Caiqing Zheng Ling Ma Fan Song Li Tian Wanzhi Cai Hu Li Yuange Duan Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene Epigenetics A-to-I RNA editing Adar Ser>Gly auto-recoding insect Drosophila adaptive |
| title | Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene |
| title_full | Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene |
| title_fullStr | Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene |
| title_full_unstemmed | Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene |
| title_short | Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene |
| title_sort | comparative genomic analyses reveal evidence for adaptive a to i rna editing in insect adar gene |
| topic | A-to-I RNA editing Adar Ser>Gly auto-recoding insect Drosophila adaptive |
| url | https://www.tandfonline.com/doi/10.1080/15592294.2024.2333665 |
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