Absence of causal relationship between Parkinson’s disease and subsequent prostate cancer: evidence from meta-analysis and Mendelian randomization studies
BackgroundNumerous observational studies have investigated the risk of prostate cancer (PCa) in patients diagnosed with Parkinson’s Disease (PD). However, the existence of a definitive association remains uncertain.MethodsSystematic searches were performed on PubMed, Web of Science, Scopus, and Goog...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1323812/full |
| _version_ | 1797365983799672832 |
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| author | Li Wang Jing-ya Deng Xi-yue Fan Dan Yang Ping-yu Zhu Xiao-ming Wang Xiao-ming Wang |
| author_facet | Li Wang Jing-ya Deng Xi-yue Fan Dan Yang Ping-yu Zhu Xiao-ming Wang Xiao-ming Wang |
| author_sort | Li Wang |
| collection | DOAJ |
| description | BackgroundNumerous observational studies have investigated the risk of prostate cancer (PCa) in patients diagnosed with Parkinson’s Disease (PD). However, the existence of a definitive association remains uncertain.MethodsSystematic searches were performed on PubMed, Web of Science, Scopus, and Google Scholar for studies published up to October 1, 2023. For Mendelian randomized (MR) causal inference, we employed pooled data from the IPDGC and PRACTICAL Consortium. The inverse variance weighted (IVW) method served as the principal technique for estimating odds ratios (ORs) and 95% confidence intervals (CIs) for the associations under investigation.ResultsCumulative analysis of nine studies revealed no significant association between patients diagnosed with PD and the subsequent incidence of PCa ([relative ratio] RR = 0.89, 95%CI = 0.73 to 1.08, P = 0.237). However, subgroup analyses indicated a reduced occurrence of PCa in Caucasian patients with PD (RR = 0.81, 95%CI = 0.69 to 0.95, P = 0.011). MR analyses failed to establish a significant link between increased genetic susceptibility to PD and the risk of PCa (IVW OR = 1.025, 95%CI = 0.997 to 1.054, P = 0.082). Sensitivity analyses further corroborated the robustness of these results.ConclusionBoth observational meta-analysis and MR analysis based on genetic variation do not support an association between PD patients and the subsequent risk of PCa. Further research is warranted to unravel the potential underlying mechanisms linking these two diseases.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023473527. |
| first_indexed | 2024-03-08T16:56:46Z |
| format | Article |
| id | doaj.art-4f63b9b4100745238953e6bd118e42a8 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T16:56:46Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4f63b9b4100745238953e6bd118e42a82024-01-04T21:35:21ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-01-011310.3389/fonc.2023.13238121323812Absence of causal relationship between Parkinson’s disease and subsequent prostate cancer: evidence from meta-analysis and Mendelian randomization studiesLi Wang0Jing-ya Deng1Xi-yue Fan2Dan Yang3Ping-yu Zhu4Xiao-ming Wang5Xiao-ming Wang6Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Neurology, Institute of Neurological Diseases of North Sichuan Medical College, Sichuan, Nanchong, ChinaBackgroundNumerous observational studies have investigated the risk of prostate cancer (PCa) in patients diagnosed with Parkinson’s Disease (PD). However, the existence of a definitive association remains uncertain.MethodsSystematic searches were performed on PubMed, Web of Science, Scopus, and Google Scholar for studies published up to October 1, 2023. For Mendelian randomized (MR) causal inference, we employed pooled data from the IPDGC and PRACTICAL Consortium. The inverse variance weighted (IVW) method served as the principal technique for estimating odds ratios (ORs) and 95% confidence intervals (CIs) for the associations under investigation.ResultsCumulative analysis of nine studies revealed no significant association between patients diagnosed with PD and the subsequent incidence of PCa ([relative ratio] RR = 0.89, 95%CI = 0.73 to 1.08, P = 0.237). However, subgroup analyses indicated a reduced occurrence of PCa in Caucasian patients with PD (RR = 0.81, 95%CI = 0.69 to 0.95, P = 0.011). MR analyses failed to establish a significant link between increased genetic susceptibility to PD and the risk of PCa (IVW OR = 1.025, 95%CI = 0.997 to 1.054, P = 0.082). Sensitivity analyses further corroborated the robustness of these results.ConclusionBoth observational meta-analysis and MR analysis based on genetic variation do not support an association between PD patients and the subsequent risk of PCa. Further research is warranted to unravel the potential underlying mechanisms linking these two diseases.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023473527.https://www.frontiersin.org/articles/10.3389/fonc.2023.1323812/fullParkinson’s diseaseprostate cancerMendelian randomizationgenetic variantsmeta-analysis |
| spellingShingle | Li Wang Jing-ya Deng Xi-yue Fan Dan Yang Ping-yu Zhu Xiao-ming Wang Xiao-ming Wang Absence of causal relationship between Parkinson’s disease and subsequent prostate cancer: evidence from meta-analysis and Mendelian randomization studies Frontiers in Oncology Parkinson’s disease prostate cancer Mendelian randomization genetic variants meta-analysis |
| title | Absence of causal relationship between Parkinson’s disease and subsequent prostate cancer: evidence from meta-analysis and Mendelian randomization studies |
| title_full | Absence of causal relationship between Parkinson’s disease and subsequent prostate cancer: evidence from meta-analysis and Mendelian randomization studies |
| title_fullStr | Absence of causal relationship between Parkinson’s disease and subsequent prostate cancer: evidence from meta-analysis and Mendelian randomization studies |
| title_full_unstemmed | Absence of causal relationship between Parkinson’s disease and subsequent prostate cancer: evidence from meta-analysis and Mendelian randomization studies |
| title_short | Absence of causal relationship between Parkinson’s disease and subsequent prostate cancer: evidence from meta-analysis and Mendelian randomization studies |
| title_sort | absence of causal relationship between parkinson s disease and subsequent prostate cancer evidence from meta analysis and mendelian randomization studies |
| topic | Parkinson’s disease prostate cancer Mendelian randomization genetic variants meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1323812/full |
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