Validation of the importance of neutrophil-to-lymphocyte ratio in non-muscle invasive bladder cancer
Background and objective: Since the peritumoral inflammatory reaction is of considerable importance in the oncological prognosis of bladder cancer, the neutrophil-to-lymphocyte ratio (NLR) may be a very practical and accessible biomarker in non-muscle invasive bladder tumors. This study aims to a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MRE Press
2022-02-01
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| Series: | Journal of Men's Health |
| Subjects: | |
| Online Access: | https://imrpress.com/journal/JOMH/18/2/10.31083/jomh.2021.128 |
| _version_ | 1827360045847805952 |
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| author | Porav-Hodade Daniel Balan Daniel Reman Tibor Balan-Bernstein Noemi Vida Arpad Oliver Martha Orsolya |
| author_facet | Porav-Hodade Daniel Balan Daniel Reman Tibor Balan-Bernstein Noemi Vida Arpad Oliver Martha Orsolya |
| author_sort | Porav-Hodade Daniel |
| collection | DOAJ |
| description | Background and objective: Since the peritumoral inflammatory reaction
is of considerable importance in the oncological prognosis of bladder cancer, the
neutrophil-to-lymphocyte ratio (NLR) may be a very practical and accessible
biomarker in non-muscle invasive bladder tumors. This study aims to analyze
parameters of non-muscle invasive bladder tumors and to identify and validate
potential tumor markers with a prognostic role in this condition.
Material and methods: 463 patients diagnosed with non-muscle invasive
urothelial tumors, between January 2016 and June 2020, hospitalized at the
Urology Clinic in Târgu Mureș, after transurethral resection of bladder tumor
(TURBT) were investigated. Inclusion criteria were: non-muscle invasive tumors
(Ta, T1, CIS), neutrophil-to-lymphocyte ratio (NLR) determination 2 weeks prior
to TURBT and complete follow-up of patients. NLR cut-off was set at 3.
Results: 371 people diagnosed with non-muscle invasive bladder tumors
met the inclusion criteria. The mean age of the included patients was 69.96 years
(IQR 35–93). 297 (80.05%) were male and 74 (19.95%) were female. 64.95% pTa
tumors, 31.26% pT1, 1.07% pTa + CIS, and 2.69% pT1 + CIS, respectively, were
identified. Distribution according to Grade: 196 (52.8%) G2, 159 (42.88%) G3
and 16 (4.32%) CIS. 284 (76.5%) patients presented with a single tumor and 87
(23.35%) with multiple tumors; 295 (79.5%) had tumors larger than 3 cm and 76
(20.5%) smaller than 3 cm. 228 (61.4%) presented with recurrence after 3 months
after surgery. Overall survival at 5 years was 80.06%. Advanced age at the time
of diagnosis correlated with low survival, p = 0.004. The mortality rate
was higher among men (20.54%) than among women (17.58%). Statistically, there
was a positive relationship between the increased ratio of neutrophils and
lymphocytes in people diagnosed with non-muscle invasive bladder cancer and
increased mortality rate, p = 0.003.
Conclusions: The overall survival of patients with non-muscle invasive
bladder cancer was negatively influenced by the advanced age of the patients at
the time of diagnosis. Increased preoperative NLR was associated with a higher
mortality rate in patients with non-muscle invasive bladder cancers. This assay is
an accessible, easy to performand useful biomarker in the prognosis of non-muscle
invasive bladder tumors. |
| first_indexed | 2024-03-08T06:40:08Z |
| format | Article |
| id | doaj.art-4f63ed7210b04c1990586166de0c6b02 |
| institution | Directory Open Access Journal |
| issn | 1875-6859 |
| language | English |
| last_indexed | 2024-03-08T06:40:08Z |
| publishDate | 2022-02-01 |
| publisher | MRE Press |
| record_format | Article |
| series | Journal of Men's Health |
| spelling | doaj.art-4f63ed7210b04c1990586166de0c6b022024-02-03T08:56:11ZengMRE PressJournal of Men's Health1875-68592022-02-0118204310.31083/jomh.2021.128S1875-6867(21)00274-8Validation of the importance of neutrophil-to-lymphocyte ratio in non-muscle invasive bladder cancerPorav-Hodade Daniel0Balan Daniel1Reman Tibor2Balan-Bernstein Noemi3Vida Arpad Oliver4Martha Orsolya5Department of Urology, University of Medicine, Pharmacy, Science and Technology "George Emil Palade" of Targu-Mures, 540139 Târgu Mureș, RomaniaDepartment of Urology, University of Medicine, Pharmacy, Science and Technology "George Emil Palade" of Targu-Mures, 540139 Târgu Mureș, RomaniaDepartment of Urology, University of Medicine, Pharmacy, Science and Technology "George Emil Palade" of Targu-Mures, 540139 Târgu Mureș, RomaniaDepartment of Pneumology, University of Medicine, Pharmacy, Science and Technology "George Emil Palade" of Targu-Mures, 540139 Târgu Mureș, RomaniaDepartment of Urology, University of Medicine, Pharmacy, Science and Technology "George Emil Palade" of Targu-Mures, 540139 Târgu Mureș, RomaniaDepartment of Urology, University of Medicine, Pharmacy, Science and Technology "George Emil Palade" of Targu-Mures, 540139 Târgu Mureș, RomaniaBackground and objective: Since the peritumoral inflammatory reaction is of considerable importance in the oncological prognosis of bladder cancer, the neutrophil-to-lymphocyte ratio (NLR) may be a very practical and accessible biomarker in non-muscle invasive bladder tumors. This study aims to analyze parameters of non-muscle invasive bladder tumors and to identify and validate potential tumor markers with a prognostic role in this condition. Material and methods: 463 patients diagnosed with non-muscle invasive urothelial tumors, between January 2016 and June 2020, hospitalized at the Urology Clinic in Târgu Mureș, after transurethral resection of bladder tumor (TURBT) were investigated. Inclusion criteria were: non-muscle invasive tumors (Ta, T1, CIS), neutrophil-to-lymphocyte ratio (NLR) determination 2 weeks prior to TURBT and complete follow-up of patients. NLR cut-off was set at 3. Results: 371 people diagnosed with non-muscle invasive bladder tumors met the inclusion criteria. The mean age of the included patients was 69.96 years (IQR 35–93). 297 (80.05%) were male and 74 (19.95%) were female. 64.95% pTa tumors, 31.26% pT1, 1.07% pTa + CIS, and 2.69% pT1 + CIS, respectively, were identified. Distribution according to Grade: 196 (52.8%) G2, 159 (42.88%) G3 and 16 (4.32%) CIS. 284 (76.5%) patients presented with a single tumor and 87 (23.35%) with multiple tumors; 295 (79.5%) had tumors larger than 3 cm and 76 (20.5%) smaller than 3 cm. 228 (61.4%) presented with recurrence after 3 months after surgery. Overall survival at 5 years was 80.06%. Advanced age at the time of diagnosis correlated with low survival, p = 0.004. The mortality rate was higher among men (20.54%) than among women (17.58%). Statistically, there was a positive relationship between the increased ratio of neutrophils and lymphocytes in people diagnosed with non-muscle invasive bladder cancer and increased mortality rate, p = 0.003. Conclusions: The overall survival of patients with non-muscle invasive bladder cancer was negatively influenced by the advanced age of the patients at the time of diagnosis. Increased preoperative NLR was associated with a higher mortality rate in patients with non-muscle invasive bladder cancers. This assay is an accessible, easy to performand useful biomarker in the prognosis of non-muscle invasive bladder tumors.https://imrpress.com/journal/JOMH/18/2/10.31083/jomh.2021.128neutrophil-to-lymphocyte rationon-muscle invasive bladder canceroverall survivalbiomarker |
| spellingShingle | Porav-Hodade Daniel Balan Daniel Reman Tibor Balan-Bernstein Noemi Vida Arpad Oliver Martha Orsolya Validation of the importance of neutrophil-to-lymphocyte ratio in non-muscle invasive bladder cancer Journal of Men's Health neutrophil-to-lymphocyte ratio non-muscle invasive bladder cancer overall survival biomarker |
| title | Validation of the importance of neutrophil-to-lymphocyte ratio in non-muscle invasive bladder cancer |
| title_full | Validation of the importance of neutrophil-to-lymphocyte ratio in non-muscle invasive bladder cancer |
| title_fullStr | Validation of the importance of neutrophil-to-lymphocyte ratio in non-muscle invasive bladder cancer |
| title_full_unstemmed | Validation of the importance of neutrophil-to-lymphocyte ratio in non-muscle invasive bladder cancer |
| title_short | Validation of the importance of neutrophil-to-lymphocyte ratio in non-muscle invasive bladder cancer |
| title_sort | validation of the importance of neutrophil to lymphocyte ratio in non muscle invasive bladder cancer |
| topic | neutrophil-to-lymphocyte ratio non-muscle invasive bladder cancer overall survival biomarker |
| url | https://imrpress.com/journal/JOMH/18/2/10.31083/jomh.2021.128 |
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