Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development
As an extracellular vesicle, exosomes play an important role in intercellular information transmission, delivering cargos of the parent cell, such as RNA, DNA, proteins, and lipids, activating different signaling pathways in the target cell and regulating inflammation, angiogenesis, and tumor progre...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023065040 |
| _version_ | 1797669893966921728 |
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| author | Siyuan Tan Haodong Tang Yang Wang Peng Xie Haifeng Li Zheng Zhang Jiahua Zhou |
| author_facet | Siyuan Tan Haodong Tang Yang Wang Peng Xie Haifeng Li Zheng Zhang Jiahua Zhou |
| author_sort | Siyuan Tan |
| collection | DOAJ |
| description | As an extracellular vesicle, exosomes play an important role in intercellular information transmission, delivering cargos of the parent cell, such as RNA, DNA, proteins, and lipids, activating different signaling pathways in the target cell and regulating inflammation, angiogenesis, and tumor progression. In particular, exosomes secreted by tumor cells can change the function of surrounding cells, creating a microenvironment conducive to tumor growth and metastasis. For example, after macrophages phagocytose exosomes and accept their cargos, they activate macrophage polarization-related signaling pathways and polarize macrophages into M1 or M2 types to exert antitumor or protumor functions. Currently, the study of exosomes affecting the polarization of macrophages has attracted increasing attention. Therefore, this paper reviews relevant studies in this field to better understand the mechanism of exosome-induced macrophage polarization and provide evidence for exploring novel targets for tumor therapy and new diagnostic markers in the future. |
| first_indexed | 2024-03-11T20:51:29Z |
| format | Article |
| id | doaj.art-4f6438d5ad134420942b3aeabc719790 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-11T20:51:29Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-4f6438d5ad134420942b3aeabc7197902023-10-01T05:59:07ZengElsevierHeliyon2405-84402023-09-0199e19296Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and developmentSiyuan Tan0Haodong Tang1Yang Wang2Peng Xie3Haifeng Li4Zheng Zhang5Jiahua Zhou6Department of Surgery, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu Province, ChinaDepartment of Surgery, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu Province, ChinaDepartment of Surgery, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu Province, China; Department of Hepato-Pancreatico-Biliary Surgery, Zhongda Hospital Southeast University, Nanjing, 210009, Jiangsu Province, ChinaDepartment of Surgery, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu Province, China; Department of Hepato-Pancreatico-Biliary Surgery, Zhongda Hospital Southeast University, Nanjing, 210009, Jiangsu Province, ChinaDepartment of Surgery, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu Province, China; Department of Hepato-Pancreatico-Biliary Surgery, Zhongda Hospital Southeast University, Nanjing, 210009, Jiangsu Province, ChinaDepartment of Surgery, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu Province, ChinaDepartment of Surgery, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu Province, China; Department of Hepato-Pancreatico-Biliary Surgery, Zhongda Hospital Southeast University, Nanjing, 210009, Jiangsu Province, China; Corresponding author. Department of Surgery, School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China.As an extracellular vesicle, exosomes play an important role in intercellular information transmission, delivering cargos of the parent cell, such as RNA, DNA, proteins, and lipids, activating different signaling pathways in the target cell and regulating inflammation, angiogenesis, and tumor progression. In particular, exosomes secreted by tumor cells can change the function of surrounding cells, creating a microenvironment conducive to tumor growth and metastasis. For example, after macrophages phagocytose exosomes and accept their cargos, they activate macrophage polarization-related signaling pathways and polarize macrophages into M1 or M2 types to exert antitumor or protumor functions. Currently, the study of exosomes affecting the polarization of macrophages has attracted increasing attention. Therefore, this paper reviews relevant studies in this field to better understand the mechanism of exosome-induced macrophage polarization and provide evidence for exploring novel targets for tumor therapy and new diagnostic markers in the future.http://www.sciencedirect.com/science/article/pii/S2405844023065040TumorExosomesMacrophage polarizationSignaling pathways |
| spellingShingle | Siyuan Tan Haodong Tang Yang Wang Peng Xie Haifeng Li Zheng Zhang Jiahua Zhou Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development Heliyon Tumor Exosomes Macrophage polarization Signaling pathways |
| title | Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development |
| title_full | Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development |
| title_fullStr | Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development |
| title_full_unstemmed | Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development |
| title_short | Tumor cell-derived exosomes regulate macrophage polarization: Emerging directions in the study of tumor genesis and development |
| title_sort | tumor cell derived exosomes regulate macrophage polarization emerging directions in the study of tumor genesis and development |
| topic | Tumor Exosomes Macrophage polarization Signaling pathways |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023065040 |
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