Evidence That Tumor Microenvironment Initiates Epithelial-To-Mesenchymal Transition and Calebin A can Suppress it in Colorectal Cancer Cells

Evidence That Tumor Microenvironment Initiates Epithelial-To-Mesenchymal Transition and Calebin A can Suppress it in Colorectal Cancer Cells

Background: Tumor microenvironment (TME) has a pivotal impact on tumor progression, and epithelial-mesenchymal transition (EMT) is an extremely crucial initial event in the metastatic process in colorectal cancer (CRC) that is not yet fully understood. Calebin A (an ingredient in Curcuma longa) has...

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Bibliographic Details
Main Authors: Constanze Buhrmann, Aranka Brockmueller, Choudhary Harsha, Ajaikumar B. Kunnumakkara, Peter Kubatka, Bharat B. Aggarwal, Mehdi Shakibaei
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
tumor microenvironment
colorecal cancer
Calebin A
EMT
focal adhesion kinase
NF- kappa B
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.699842/full

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