The genetic communication and interaction between chronic kidney diseases and frailty
Abstract The prevalence of chronic kidney disease (CKD) is increasing due to the global ageing trend. Despite significant advancements in understanding the mechanisms of CKD, little research has focused on the prevention and treatment of associated complications such as frailty. In this review, we p...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | Clinical and Translational Discovery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctd2.233 |
| _version_ | 1797736136627453952 |
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| author | Xiaojun Wang Xuchao Gu Yuxin Zhang Zhijun Bao |
| author_facet | Xiaojun Wang Xuchao Gu Yuxin Zhang Zhijun Bao |
| author_sort | Xiaojun Wang |
| collection | DOAJ |
| description | Abstract The prevalence of chronic kidney disease (CKD) is increasing due to the global ageing trend. Despite significant advancements in understanding the mechanisms of CKD, little research has focused on the prevention and treatment of associated complications such as frailty. In this review, we provide a summary of the current Genome‐Wide Association Studies (GWAS) of kidney diseases based on the unique genetic characteristics of kidneys and a review of the impact of metabolites associated with inflammageing on frailty and CKD. Additionally, the role of circadian rhythm in the intrinsic relationship between kidney and skeletal muscle has also been explored. This article offers insights into the potential communications and interactions between CKD and frailty to facilitate the current clinical treatments and improve the life quality for frail elderly individuals in coexistence of CKD. |
| first_indexed | 2024-03-12T13:09:13Z |
| format | Article |
| id | doaj.art-4f64bc9bb77b41e2b3f3f96a305f0ce1 |
| institution | Directory Open Access Journal |
| issn | 2768-0622 |
| language | English |
| last_indexed | 2024-03-12T13:09:13Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Discovery |
| spelling | doaj.art-4f64bc9bb77b41e2b3f3f96a305f0ce12023-08-28T06:44:32ZengWileyClinical and Translational Discovery2768-06222023-08-0134n/an/a10.1002/ctd2.233The genetic communication and interaction between chronic kidney diseases and frailtyXiaojun Wang0Xuchao Gu1Yuxin Zhang2Zhijun Bao3Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan University Shanghai ChinaShanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan University Shanghai ChinaDepartment of Plastic Surgery Huadong Hospital Affiliated Fudan University Shanghai ChinaShanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan University Shanghai ChinaAbstract The prevalence of chronic kidney disease (CKD) is increasing due to the global ageing trend. Despite significant advancements in understanding the mechanisms of CKD, little research has focused on the prevention and treatment of associated complications such as frailty. In this review, we provide a summary of the current Genome‐Wide Association Studies (GWAS) of kidney diseases based on the unique genetic characteristics of kidneys and a review of the impact of metabolites associated with inflammageing on frailty and CKD. Additionally, the role of circadian rhythm in the intrinsic relationship between kidney and skeletal muscle has also been explored. This article offers insights into the potential communications and interactions between CKD and frailty to facilitate the current clinical treatments and improve the life quality for frail elderly individuals in coexistence of CKD.https://doi.org/10.1002/ctd2.233circadian rhythmCKDfrailtygenetic genesinflammageing |
| spellingShingle | Xiaojun Wang Xuchao Gu Yuxin Zhang Zhijun Bao The genetic communication and interaction between chronic kidney diseases and frailty Clinical and Translational Discovery circadian rhythm CKD frailty genetic genes inflammageing |
| title | The genetic communication and interaction between chronic kidney diseases and frailty |
| title_full | The genetic communication and interaction between chronic kidney diseases and frailty |
| title_fullStr | The genetic communication and interaction between chronic kidney diseases and frailty |
| title_full_unstemmed | The genetic communication and interaction between chronic kidney diseases and frailty |
| title_short | The genetic communication and interaction between chronic kidney diseases and frailty |
| title_sort | genetic communication and interaction between chronic kidney diseases and frailty |
| topic | circadian rhythm CKD frailty genetic genes inflammageing |
| url | https://doi.org/10.1002/ctd2.233 |
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