Gut microbiota and its therapeutic implications in tumor microenvironment interactions
The development of cancer is not just the growth and proliferation of a single transformed cell, but its tumor microenvironment (TME) also coevolves with it, which is primarily involved in tumor initiation, development, metastasis, and therapeutic responses. Recent years, TME has been emerged as a p...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1287077/full |
| _version_ | 1827376285405413376 |
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| author | Pengya Feng Pengya Feng Pengya Feng Xia Xue Xia Xue Ihtisham Bukhari Ihtisham Bukhari Chunjing Qiu Chunjing Qiu Yingying Li Yingying Li Pengyuan Zheng Pengyuan Zheng Yang Mi Yang Mi |
| author_facet | Pengya Feng Pengya Feng Pengya Feng Xia Xue Xia Xue Ihtisham Bukhari Ihtisham Bukhari Chunjing Qiu Chunjing Qiu Yingying Li Yingying Li Pengyuan Zheng Pengyuan Zheng Yang Mi Yang Mi |
| author_sort | Pengya Feng |
| collection | DOAJ |
| description | The development of cancer is not just the growth and proliferation of a single transformed cell, but its tumor microenvironment (TME) also coevolves with it, which is primarily involved in tumor initiation, development, metastasis, and therapeutic responses. Recent years, TME has been emerged as a potential target for cancer diagnosis and treatment. However, the clinical efficacy of treatments targeting the TME, especially its specific components, remains insufficient. In parallel, the gut microbiome is an essential TME component that is crucial in cancer immunotherapy. Thus, assessing and constructing frameworks between the gut microbiota and the TME can significantly enhance the exploration of effective treatment strategies for various tumors. In this review the role of the gut microbiota in human cancers, including its function and relationship with various tumors was summarized. In addition, the interaction between the gut microbiota and the TME as well as its potential applications in cancer therapeutics was described. Furthermore, it was summarized that fecal microbiota transplantation, dietary adjustments, and synthetic biology to introduce gut microbiota-based medical technologies for cancer treatment. This review provides a comprehensive summary for uncovering the mechanism underlying the effects of the gut microbiota on the TME and lays a foundation for the development of personalized medicine in further studies. |
| first_indexed | 2024-03-08T12:07:37Z |
| format | Article |
| id | doaj.art-4f65e1b867c840808d03a3195d7e3ad8 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-08T12:07:37Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-4f65e1b867c840808d03a3195d7e3ad82024-01-23T04:45:17ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-01-011510.3389/fmicb.2024.12870771287077Gut microbiota and its therapeutic implications in tumor microenvironment interactionsPengya Feng0Pengya Feng1Pengya Feng2Xia Xue3Xia Xue4Ihtisham Bukhari5Ihtisham Bukhari6Chunjing Qiu7Chunjing Qiu8Yingying Li9Yingying Li10Pengyuan Zheng11Pengyuan Zheng12Yang Mi13Yang Mi14Key Laboratory of Helicobacter Pylori, Microbiota and Gastrointestinal Cancer of Henan Province, Marshall Medical Research Center, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Children Rehabilitation Medicine, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Gastroenterology, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Helicobacter Pylori, Microbiota and Gastrointestinal Cancer of Henan Province, Marshall Medical Research Center, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Gastroenterology, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Helicobacter Pylori, Microbiota and Gastrointestinal Cancer of Henan Province, Marshall Medical Research Center, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Gastroenterology, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Helicobacter Pylori, Microbiota and Gastrointestinal Cancer of Henan Province, Marshall Medical Research Center, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Gastroenterology, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Helicobacter Pylori, Microbiota and Gastrointestinal Cancer of Henan Province, Marshall Medical Research Center, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Gastroenterology, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Helicobacter Pylori, Microbiota and Gastrointestinal Cancer of Henan Province, Marshall Medical Research Center, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Gastroenterology, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaKey Laboratory of Helicobacter Pylori, Microbiota and Gastrointestinal Cancer of Henan Province, Marshall Medical Research Center, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Gastroenterology, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaThe development of cancer is not just the growth and proliferation of a single transformed cell, but its tumor microenvironment (TME) also coevolves with it, which is primarily involved in tumor initiation, development, metastasis, and therapeutic responses. Recent years, TME has been emerged as a potential target for cancer diagnosis and treatment. However, the clinical efficacy of treatments targeting the TME, especially its specific components, remains insufficient. In parallel, the gut microbiome is an essential TME component that is crucial in cancer immunotherapy. Thus, assessing and constructing frameworks between the gut microbiota and the TME can significantly enhance the exploration of effective treatment strategies for various tumors. In this review the role of the gut microbiota in human cancers, including its function and relationship with various tumors was summarized. In addition, the interaction between the gut microbiota and the TME as well as its potential applications in cancer therapeutics was described. Furthermore, it was summarized that fecal microbiota transplantation, dietary adjustments, and synthetic biology to introduce gut microbiota-based medical technologies for cancer treatment. This review provides a comprehensive summary for uncovering the mechanism underlying the effects of the gut microbiota on the TME and lays a foundation for the development of personalized medicine in further studies.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1287077/fullcancer therapygut microbiotamicrobiota tumor microenvironmentsynthetic biologytherapeutic target |
| spellingShingle | Pengya Feng Pengya Feng Pengya Feng Xia Xue Xia Xue Ihtisham Bukhari Ihtisham Bukhari Chunjing Qiu Chunjing Qiu Yingying Li Yingying Li Pengyuan Zheng Pengyuan Zheng Yang Mi Yang Mi Gut microbiota and its therapeutic implications in tumor microenvironment interactions Frontiers in Microbiology cancer therapy gut microbiota microbiota tumor microenvironment synthetic biology therapeutic target |
| title | Gut microbiota and its therapeutic implications in tumor microenvironment interactions |
| title_full | Gut microbiota and its therapeutic implications in tumor microenvironment interactions |
| title_fullStr | Gut microbiota and its therapeutic implications in tumor microenvironment interactions |
| title_full_unstemmed | Gut microbiota and its therapeutic implications in tumor microenvironment interactions |
| title_short | Gut microbiota and its therapeutic implications in tumor microenvironment interactions |
| title_sort | gut microbiota and its therapeutic implications in tumor microenvironment interactions |
| topic | cancer therapy gut microbiota microbiota tumor microenvironment synthetic biology therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1287077/full |
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