Angiopoietin-2 is associated with albuminuria and microinflammation in chronic kidney disease.
Although cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD), the pathophysiology is not thoroughly understood. Given that elevated albuminuria or circulating angiopoietin-2 associates with CVD and mortality in CKD patients, we were intrigued...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3585725?pdf=render |
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| author | Fan-Chi Chang Tai-Shuan Lai Chih-Kang Chiang Yung-Ming Chen Ming-Shiou Wu Tzong-Shinn Chu Kwan-Dun Wu Shuei-Liong Lin |
| author_facet | Fan-Chi Chang Tai-Shuan Lai Chih-Kang Chiang Yung-Ming Chen Ming-Shiou Wu Tzong-Shinn Chu Kwan-Dun Wu Shuei-Liong Lin |
| author_sort | Fan-Chi Chang |
| collection | DOAJ |
| description | Although cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD), the pathophysiology is not thoroughly understood. Given that elevated albuminuria or circulating angiopoietin-2 associates with CVD and mortality in CKD patients, we were intrigued by the relationship between albuminuria and angiopoietin-2. A total of 416 patients with CKD stages 3 to 5 were stratified by urine albumin-creatinine ratio as normoalbuminuria (<30 mg/g), microalbuminuria (30-300 mg/g), or macroalbuminuria (>300 mg/g). The levels of plasma angiopoietin-2 and vascular endothelial growth factor (VEGF) increased, and soluble Tie-2 decreased in the subgroups of albuminuria; whereas angiopoietin-1 did not change. Linear regression showed a positive correlation between urine albumin-creatinine ratio (ACR) and plasma angiopoietin-2 (correlation coefficient r = 0.301, 95% confidence interval 0.211-0.386, P<0.0001), but not between ACR and VEGF or soluble Tie-2. Multivariate linear regression analysis showed that plasma angiopoietin-2 was independently associated with ACR (P = 0.025). Furthermore, plasma angiopoietin-2 was positively correlated with high sensitive C-reactive protein (r = 0.114, 95% confidence interval 0.018-0.208, P = 0.020). In conclusion, plasma angiopoietin-2 was associated with albuminuria and markers of systemic microinflammation in CKD patients. Although previous evidence has shown that angiopoietin-2 destabilizes vasculature and induces inflammation in different scenarios, further study will be required to delineate the role of angiopoietin-2 in albuminuria and microinflammation in CKD patients. |
| first_indexed | 2024-04-12T11:56:49Z |
| format | Article |
| id | doaj.art-4f669cd0fff647a0bcb65d8ff30c48d1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T11:56:49Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4f669cd0fff647a0bcb65d8ff30c48d12022-12-22T03:33:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5466810.1371/journal.pone.0054668Angiopoietin-2 is associated with albuminuria and microinflammation in chronic kidney disease.Fan-Chi ChangTai-Shuan LaiChih-Kang ChiangYung-Ming ChenMing-Shiou WuTzong-Shinn ChuKwan-Dun WuShuei-Liong LinAlthough cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD), the pathophysiology is not thoroughly understood. Given that elevated albuminuria or circulating angiopoietin-2 associates with CVD and mortality in CKD patients, we were intrigued by the relationship between albuminuria and angiopoietin-2. A total of 416 patients with CKD stages 3 to 5 were stratified by urine albumin-creatinine ratio as normoalbuminuria (<30 mg/g), microalbuminuria (30-300 mg/g), or macroalbuminuria (>300 mg/g). The levels of plasma angiopoietin-2 and vascular endothelial growth factor (VEGF) increased, and soluble Tie-2 decreased in the subgroups of albuminuria; whereas angiopoietin-1 did not change. Linear regression showed a positive correlation between urine albumin-creatinine ratio (ACR) and plasma angiopoietin-2 (correlation coefficient r = 0.301, 95% confidence interval 0.211-0.386, P<0.0001), but not between ACR and VEGF or soluble Tie-2. Multivariate linear regression analysis showed that plasma angiopoietin-2 was independently associated with ACR (P = 0.025). Furthermore, plasma angiopoietin-2 was positively correlated with high sensitive C-reactive protein (r = 0.114, 95% confidence interval 0.018-0.208, P = 0.020). In conclusion, plasma angiopoietin-2 was associated with albuminuria and markers of systemic microinflammation in CKD patients. Although previous evidence has shown that angiopoietin-2 destabilizes vasculature and induces inflammation in different scenarios, further study will be required to delineate the role of angiopoietin-2 in albuminuria and microinflammation in CKD patients.http://europepmc.org/articles/PMC3585725?pdf=render |
| spellingShingle | Fan-Chi Chang Tai-Shuan Lai Chih-Kang Chiang Yung-Ming Chen Ming-Shiou Wu Tzong-Shinn Chu Kwan-Dun Wu Shuei-Liong Lin Angiopoietin-2 is associated with albuminuria and microinflammation in chronic kidney disease. PLoS ONE |
| title | Angiopoietin-2 is associated with albuminuria and microinflammation in chronic kidney disease. |
| title_full | Angiopoietin-2 is associated with albuminuria and microinflammation in chronic kidney disease. |
| title_fullStr | Angiopoietin-2 is associated with albuminuria and microinflammation in chronic kidney disease. |
| title_full_unstemmed | Angiopoietin-2 is associated with albuminuria and microinflammation in chronic kidney disease. |
| title_short | Angiopoietin-2 is associated with albuminuria and microinflammation in chronic kidney disease. |
| title_sort | angiopoietin 2 is associated with albuminuria and microinflammation in chronic kidney disease |
| url | http://europepmc.org/articles/PMC3585725?pdf=render |
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