The role of selenium in autoimmune thyroiditis
Selenium (Se) is an essential trace element of fundamental importance for human health. Se is incorporated into selenoproteins (SPs) which are endowed with pleiotropic effects including antioxidant and anti-inflammatory effects and active production of thyroid hormones. It has also been suggested t...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2024-03-01
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| Series: | Journal of Biological Research |
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| Online Access: | https://www.pagepressjournals.org/jbr/article/view/12050 |
| _version_ | 1827311986307760128 |
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| author | Marco Giammanco Vincenza M.E. Bonfiglio Manfredi M. Giammanco Francesco Carini |
| author_facet | Marco Giammanco Vincenza M.E. Bonfiglio Manfredi M. Giammanco Francesco Carini |
| author_sort | Marco Giammanco |
| collection | DOAJ |
| description |
Selenium (Se) is an essential trace element of fundamental importance for human health. Se is incorporated into selenoproteins (SPs) which are endowed with pleiotropic effects including antioxidant and anti-inflammatory effects and active production of thyroid hormones. It has also been suggested that Se plays a crucial role in the pathogenesis of various human diseases. The therapeutic effects of supplementation with Se have already been described in various thyroid diseases. However, there are still conflicting results regarding the optimal dose of Se to administer and the duration of treatment, efficacy, and safety. The highly beneficial effects of supplementation with Se have been observed in subjects with thyroid disease in the hyperthyroid phase. In line with these observations, clinical studies have shown that in patients with Basedow's disease (BD) and autoimmune thyroiditis (AT), treatment with a combination of antithyroid drugs and Se restores the euthyroid state faster than administration of antithyroid drugs alone. However, the efficacy of this therapeutic approach remains to be better evaluated.
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| first_indexed | 2024-04-24T20:28:55Z |
| format | Article |
| id | doaj.art-4f66cafd7e744475b7f9a7a5e51a96fc |
| institution | Directory Open Access Journal |
| issn | 1826-8838 2284-0230 |
| language | English |
| last_indexed | 2024-04-24T20:28:55Z |
| publishDate | 2024-03-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Journal of Biological Research |
| spelling | doaj.art-4f66cafd7e744475b7f9a7a5e51a96fc2024-03-21T23:14:42ZengPAGEPress PublicationsJournal of Biological Research1826-88382284-02302024-03-0110.4081/jbr.2024.12050The role of selenium in autoimmune thyroiditisMarco Giammanco0Vincenza M.E. Bonfiglio1Manfredi M. Giammanco2Francesco Carini3Department of Precision Medicine in the Medical, Surgical, and Intensive care fields (Me.Pre.C.C.), University of PalermoDepartment of Biomedical Neuroscience and Advanced Diagnosis, University of PalermoDepartment of Biomedical Neuroscience and Advanced Diagnosis, University of PalermoDepartment of Biomedical Neuroscience and Advanced Diagnosis, University of Palermo Selenium (Se) is an essential trace element of fundamental importance for human health. Se is incorporated into selenoproteins (SPs) which are endowed with pleiotropic effects including antioxidant and anti-inflammatory effects and active production of thyroid hormones. It has also been suggested that Se plays a crucial role in the pathogenesis of various human diseases. The therapeutic effects of supplementation with Se have already been described in various thyroid diseases. However, there are still conflicting results regarding the optimal dose of Se to administer and the duration of treatment, efficacy, and safety. The highly beneficial effects of supplementation with Se have been observed in subjects with thyroid disease in the hyperthyroid phase. In line with these observations, clinical studies have shown that in patients with Basedow's disease (BD) and autoimmune thyroiditis (AT), treatment with a combination of antithyroid drugs and Se restores the euthyroid state faster than administration of antithyroid drugs alone. However, the efficacy of this therapeutic approach remains to be better evaluated. https://www.pagepressjournals.org/jbr/article/view/12050Seleniumnutritionthyroid hormonesautoimmune thyroiditisBasedow’s disease |
| spellingShingle | Marco Giammanco Vincenza M.E. Bonfiglio Manfredi M. Giammanco Francesco Carini The role of selenium in autoimmune thyroiditis Journal of Biological Research Selenium nutrition thyroid hormones autoimmune thyroiditis Basedow’s disease |
| title | The role of selenium in autoimmune thyroiditis |
| title_full | The role of selenium in autoimmune thyroiditis |
| title_fullStr | The role of selenium in autoimmune thyroiditis |
| title_full_unstemmed | The role of selenium in autoimmune thyroiditis |
| title_short | The role of selenium in autoimmune thyroiditis |
| title_sort | role of selenium in autoimmune thyroiditis |
| topic | Selenium nutrition thyroid hormones autoimmune thyroiditis Basedow’s disease |
| url | https://www.pagepressjournals.org/jbr/article/view/12050 |
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