A novel synthetic microtubule inhibitor exerts antiproliferative effects in multidrug resistant cancer cells and cancer stem cells
Abstract The success of cancer chemotherapy is limited by multidrug resistance (MDR), which is mainly caused by P-glycoprotein (P-gp) overexpression. In the present study, we describe a novel microtubule inhibitor, 5-(N-methylmaleimid-3-yl)-chromone (SPC-160002), that can be used to overcome MDR. A...
Main Authors: | Mina Park, Jee Won Hwang, Yena Cho, Saegun Kim, Sang Hoon Han, Jinsuh Yu, Sojung Ha, Woo-Young Kim, Su-Nam Kim, In Su Kim, Yong Kee Kim |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2021-05-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-021-90337-w |
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