Sclareol Inhibits Hypoxia-Inducible Factor-1α Accumulation and Induces Apoptosis in Hypoxic Cancer Cells
Purpose: The hypoxia in solid tumors is associated with the resistance to chemo/radiotherapy.Hypoxia-inducible factor-1 (HIF-1) plays a key role in cell remodeling to hypoxia. Therefore, theinhibition of HIF-1 accumulation is considered a hopeful strategy for the treatment of cancer.Here, we aimed t...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Tabriz University of Medical Sciences
2022-05-01
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Series: | Advanced Pharmaceutical Bulletin |
Subjects: | |
Online Access: | https://apb.tbzmed.ac.ir/PDF/apb-12-593.pdf |