Sclareol Inhibits Hypoxia-Inducible Factor-1α Accumulation and Induces Apoptosis in Hypoxic Cancer Cells

Sclareol Inhibits Hypoxia-Inducible Factor-1α Accumulation and Induces Apoptosis in Hypoxic Cancer Cells

Purpose: The hypoxia in solid tumors is associated with the resistance to chemo/radiotherapy.Hypoxia-inducible factor-1 (HIF-1) plays a key role in cell remodeling to hypoxia. Therefore, theinhibition of HIF-1 accumulation is considered a hopeful strategy for the treatment of cancer.Here, we aimed t...

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Bibliographic Details
Main Authors:	Somayeh Vandghanooni, Zahra Farajzadeh Vahid, Ailar Nakhlband, Mir Babak Bahadori, Morteza Eskandani
Format:	Article
Language:	English
Published:	Tabriz University of Medical Sciences 2022-05-01
Series:	Advanced Pharmaceutical Bulletin
Subjects:	sclareol natural compound a549 lung cancer hypoxia hif-1α
Online Access:	https://apb.tbzmed.ac.ir/PDF/apb-12-593.pdf

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