Biochemical characteristics of patients with imported malaria
ObjectivesThis study aimed to investigate the clinical and biochemical profiles of patients with imported malaria infection between 1 January 2011 and 30 April 2022 and admitted to the Fourth People’s Hospital of Nanning.MethodsThis cohort study enrolled 170 patients with conformed imported malaria...
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| Format: | Article |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1008430/full |
| _version_ | 1797988949585559552 |
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| author | Dewu Bi Dewu Bi Jianyan Lin Jianyan Lin Xiaolu Luo Xiaolu Luo Lü Lin Lü Lin Xike Tang Xike Tang Xiaocheng Luo Xiaocheng Luo Yuexi Lu Yuexi Lu Xiaodong Huang Xiaodong Huang |
| author_facet | Dewu Bi Dewu Bi Jianyan Lin Jianyan Lin Xiaolu Luo Xiaolu Luo Lü Lin Lü Lin Xike Tang Xike Tang Xiaocheng Luo Xiaocheng Luo Yuexi Lu Yuexi Lu Xiaodong Huang Xiaodong Huang |
| author_sort | Dewu Bi |
| collection | DOAJ |
| description | ObjectivesThis study aimed to investigate the clinical and biochemical profiles of patients with imported malaria infection between 1 January 2011 and 30 April 2022 and admitted to the Fourth People’s Hospital of Nanning.MethodsThis cohort study enrolled 170 patients with conformed imported malaria infection. The clinical and biochemical profiles of these participants were analyzed with malaria parasite clearance, and signs and symptoms related to malaria disappearance were defined as the primary outcome. A multivariable logistic regression model was used to evaluate the odds ratios (ORs) with 95% confidence intervals (CIs) for cerebral malaria. The Cox model was used to estimate the hazard ratios (HRs) with 95% CIs for parasite clearance.ResultsAdenosine deaminase and parasitemia were found to be independent risk factors for severe malaria in patients with imported malaria (OR = 1.0088, 95% CI: 1.0010–1.0167, p = 0.0272 and OR = 2.0700, 95% CI: 1.2584–3.4050, p = 0.0042, respectively). A 0.5–standard deviation (SD) increase of variation for urea (HR = 0.6714, 95% CI: 0.4911–0.9180), a 0.5-SD increase of variation for creatinine (HR = 0.4566, 95% CI: 0.2762–0.7548), a 0.25-SD increase of variation for albumin (HR = 0.4947, 95% CI: 0.3197–0.7653), a 0.25-SD increase of variation for hydroxybutyrate dehydrogenase (HR = 0.6129, 95% CI: 0.3995–0.9402), and a 1.0-SD increase of variation for ferritin (HR = 0.5887, 95% CI: 0.3799–0.9125) were associated with a higher risk for increased parasite clearance duration than a low-level change.ConclusionsAspartate aminotransferase, urea, creatinine, albumin, hydroxybutyrate dehydrogenase, and ferritin are useful biochemical indicators in routine clinical practice to evaluate prognosis for imported malaria. |
| first_indexed | 2024-04-11T08:11:26Z |
| format | Article |
| id | doaj.art-4f68cd7df5874400a8dcce967b2e5fb5 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-11T08:11:26Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-4f68cd7df5874400a8dcce967b2e5fb52022-12-22T04:35:19ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-11-011210.3389/fcimb.2022.10084301008430Biochemical characteristics of patients with imported malariaDewu Bi0Dewu Bi1Jianyan Lin2Jianyan Lin3Xiaolu Luo4Xiaolu Luo5Lü Lin6Lü Lin7Xike Tang8Xike Tang9Xiaocheng Luo10Xiaocheng Luo11Yuexi Lu12Yuexi Lu13Xiaodong Huang14Xiaodong Huang15Department of Clinical Laboratory, Fourth People’s Hospital of Nanning, Nanning, Guangxi, ChinaAffiliated Infectious Disease Hospital of Nanning, Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Clinical Laboratory, Fourth People’s Hospital of Nanning, Nanning, Guangxi, ChinaAffiliated Infectious Disease Hospital of Nanning, Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Clinical Laboratory, Fourth People’s Hospital of Nanning, Nanning, Guangxi, ChinaAffiliated Infectious Disease Hospital of Nanning, Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Clinical Laboratory, Fourth People’s Hospital of Nanning, Nanning, Guangxi, ChinaAffiliated Infectious Disease Hospital of Nanning, Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Clinical Laboratory, Fourth People’s Hospital of Nanning, Nanning, Guangxi, ChinaAffiliated Infectious Disease Hospital of Nanning, Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Clinical Laboratory, Fourth People’s Hospital of Nanning, Nanning, Guangxi, ChinaAffiliated Infectious Disease Hospital of Nanning, Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Clinical Laboratory, Fourth People’s Hospital of Nanning, Nanning, Guangxi, ChinaAffiliated Infectious Disease Hospital of Nanning, Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Clinical Laboratory, Fourth People’s Hospital of Nanning, Nanning, Guangxi, ChinaAffiliated Infectious Disease Hospital of Nanning, Guangxi Medical University, Nanning, Guangxi, ChinaObjectivesThis study aimed to investigate the clinical and biochemical profiles of patients with imported malaria infection between 1 January 2011 and 30 April 2022 and admitted to the Fourth People’s Hospital of Nanning.MethodsThis cohort study enrolled 170 patients with conformed imported malaria infection. The clinical and biochemical profiles of these participants were analyzed with malaria parasite clearance, and signs and symptoms related to malaria disappearance were defined as the primary outcome. A multivariable logistic regression model was used to evaluate the odds ratios (ORs) with 95% confidence intervals (CIs) for cerebral malaria. The Cox model was used to estimate the hazard ratios (HRs) with 95% CIs for parasite clearance.ResultsAdenosine deaminase and parasitemia were found to be independent risk factors for severe malaria in patients with imported malaria (OR = 1.0088, 95% CI: 1.0010–1.0167, p = 0.0272 and OR = 2.0700, 95% CI: 1.2584–3.4050, p = 0.0042, respectively). A 0.5–standard deviation (SD) increase of variation for urea (HR = 0.6714, 95% CI: 0.4911–0.9180), a 0.5-SD increase of variation for creatinine (HR = 0.4566, 95% CI: 0.2762–0.7548), a 0.25-SD increase of variation for albumin (HR = 0.4947, 95% CI: 0.3197–0.7653), a 0.25-SD increase of variation for hydroxybutyrate dehydrogenase (HR = 0.6129, 95% CI: 0.3995–0.9402), and a 1.0-SD increase of variation for ferritin (HR = 0.5887, 95% CI: 0.3799–0.9125) were associated with a higher risk for increased parasite clearance duration than a low-level change.ConclusionsAspartate aminotransferase, urea, creatinine, albumin, hydroxybutyrate dehydrogenase, and ferritin are useful biochemical indicators in routine clinical practice to evaluate prognosis for imported malaria.https://www.frontiersin.org/articles/10.3389/fcimb.2022.1008430/fullimported malariabiochemical outcomesrisk factorparasite clearanceprognostic model |
| spellingShingle | Dewu Bi Dewu Bi Jianyan Lin Jianyan Lin Xiaolu Luo Xiaolu Luo Lü Lin Lü Lin Xike Tang Xike Tang Xiaocheng Luo Xiaocheng Luo Yuexi Lu Yuexi Lu Xiaodong Huang Xiaodong Huang Biochemical characteristics of patients with imported malaria Frontiers in Cellular and Infection Microbiology imported malaria biochemical outcomes risk factor parasite clearance prognostic model |
| title | Biochemical characteristics of patients with imported malaria |
| title_full | Biochemical characteristics of patients with imported malaria |
| title_fullStr | Biochemical characteristics of patients with imported malaria |
| title_full_unstemmed | Biochemical characteristics of patients with imported malaria |
| title_short | Biochemical characteristics of patients with imported malaria |
| title_sort | biochemical characteristics of patients with imported malaria |
| topic | imported malaria biochemical outcomes risk factor parasite clearance prognostic model |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1008430/full |
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