CCR9 axis inhibition enhances hepatic migration of plasmacytoid DCs and protects against liver injury

CCR9 axis inhibition enhances hepatic migration of plasmacytoid DCs and protects against liver injury

Plasmacytoid dendritic cells (pDCs) perform dual proinflammatory and immunosuppressive roles. We recently reported the potential of pDC therapy for treatment of intractable acute liver failure. However, establishment of efficient methods to deliver pDCs to the liver is essential for future clinical...

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Bibliographic Details
Main Authors: Yuzo Koda, Nobuhiro Nakamoto, Po-Sung Chu, Toshiaki Teratani, Akihisa Ueno, Takeru Amiya, Nobuhito Taniki, Sayako Chiba, Kentaro Miyamoto, Michiie Sakamoto, Takanori Kanai
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-09-01
Series:JCI Insight
Subjects:
Hepatology
Immunology
Online Access:https://doi.org/10.1172/jci.insight.159910

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