Cancer immunometabolism: advent, challenges, and perspective
Abstract For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism to the center stage of innate and adaptive immunomodulation. Given this, we focus on changes...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-04-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-024-01981-5 |
| _version_ | 1797219996023128064 |
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| author | Qin Dang Borui Li Bing Jin Zeng Ye Xin Lou Ting Wang Yan Wang Xuan Pan Qiangsheng Hu Zheng Li Shunrong Ji Chenjie Zhou Xianjun Yu Yi Qin Xiaowu Xu |
| author_facet | Qin Dang Borui Li Bing Jin Zeng Ye Xin Lou Ting Wang Yan Wang Xuan Pan Qiangsheng Hu Zheng Li Shunrong Ji Chenjie Zhou Xianjun Yu Yi Qin Xiaowu Xu |
| author_sort | Qin Dang |
| collection | DOAJ |
| description | Abstract For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism to the center stage of innate and adaptive immunomodulation. Given this, we focus on changes in immunometabolism, a converging series of biochemical events that alters immune cell function, propose the immune roles played by diversified metabolic derivatives and enzymes, emphasize the key metabolism-related checkpoints in distinct immune cell types, and discuss the ongoing and upcoming realities of clinical treatment. It is expected that future research will reduce the current limitations of immunotherapy and provide a positive hand in immune responses to exert a broader therapeutic role. |
| first_indexed | 2024-04-24T12:42:31Z |
| format | Article |
| id | doaj.art-4f69a13e8cb647ed8701a321ece4ee74 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-04-24T12:42:31Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-4f69a13e8cb647ed8701a321ece4ee742024-04-07T11:10:36ZengBMCMolecular Cancer1476-45982024-04-0123112210.1186/s12943-024-01981-5Cancer immunometabolism: advent, challenges, and perspectiveQin Dang0Borui Li1Bing Jin2Zeng Ye3Xin Lou4Ting Wang5Yan Wang6Xuan Pan7Qiangsheng Hu8Zheng Li9Shunrong Ji10Chenjie Zhou11Xianjun Yu12Yi Qin13Xiaowu Xu14Department of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterSchool of Clinical Medicine, Zhengzhou UniversityDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Hepatobiliary Surgery, Yijishan Hospital, The First Affiliated Hospital of Wannan Medical CollegeDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji UniversityDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterAbstract For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism to the center stage of innate and adaptive immunomodulation. Given this, we focus on changes in immunometabolism, a converging series of biochemical events that alters immune cell function, propose the immune roles played by diversified metabolic derivatives and enzymes, emphasize the key metabolism-related checkpoints in distinct immune cell types, and discuss the ongoing and upcoming realities of clinical treatment. It is expected that future research will reduce the current limitations of immunotherapy and provide a positive hand in immune responses to exert a broader therapeutic role.https://doi.org/10.1186/s12943-024-01981-5ImmunometabolismMetabolic reprogrammingImmunityMetabolic adaptationCancer-immunity cycleCancer-immunometabolism subcycle |
| spellingShingle | Qin Dang Borui Li Bing Jin Zeng Ye Xin Lou Ting Wang Yan Wang Xuan Pan Qiangsheng Hu Zheng Li Shunrong Ji Chenjie Zhou Xianjun Yu Yi Qin Xiaowu Xu Cancer immunometabolism: advent, challenges, and perspective Molecular Cancer Immunometabolism Metabolic reprogramming Immunity Metabolic adaptation Cancer-immunity cycle Cancer-immunometabolism subcycle |
| title | Cancer immunometabolism: advent, challenges, and perspective |
| title_full | Cancer immunometabolism: advent, challenges, and perspective |
| title_fullStr | Cancer immunometabolism: advent, challenges, and perspective |
| title_full_unstemmed | Cancer immunometabolism: advent, challenges, and perspective |
| title_short | Cancer immunometabolism: advent, challenges, and perspective |
| title_sort | cancer immunometabolism advent challenges and perspective |
| topic | Immunometabolism Metabolic reprogramming Immunity Metabolic adaptation Cancer-immunity cycle Cancer-immunometabolism subcycle |
| url | https://doi.org/10.1186/s12943-024-01981-5 |
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