Solving manufacturing problems for L-carnitine-L-tartrate to improve the likelihood of successful product scale-up

Solving manufacturing problems for L-carnitine-L-tartrate to improve the likelihood of successful product scale-up

L-carnitine-L-tartrate, a non-essential amino acid, is hygroscopic. This causes a problem in tablet production due to pronounced adhesion of tablets to punches. A 33 full factorial design was adopted to suggest a tablet formulation. Three adsorbents were suggested (Aerosil 200, Aerosil R972, talc) t...

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Bibliographic Details
Main Authors: Badawi Aliaa A., Hegazy Mahmoud M., Louis Dina, Eldegwy Mohammed A.
Format: Article
Language:English
Published: Sciendo 2017-12-01
Series:Acta Pharmaceutica
Subjects:
l-carnitine-l-tartrate
adsorbent
scale-up
compression force
ejection force
hygroscopic
Online Access:https://doi.org/10.1515/acph-2017-0033

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