Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 Mice

Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 Mice

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can cause neurological disease in humans, but little is known about the pathogenesis of SARS-CoV-2 infection in the central nervous system (CNS). Herein, using K18-hACE2 mice, we demonstrate that SARS-CoV-2 neuroinvasion and ence...

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Bibliographic Details
Main Authors: Pratima Kumari, Hussin A. Rothan, Janhavi P. Natekar, Shannon Stone, Heather Pathak, Philip G. Strate, Komal Arora, Margo A. Brinton, Mukesh Kumar
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Viruses
Subjects:
SARS-CoV-2
COVID-19
K18-hACE2 mice
neuroinvasion
neuroinflammation
encephalitis
Online Access:https://www.mdpi.com/1999-4915/13/1/132

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https://www.mdpi.com/1999-4915/13/1/132

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