Caspase 3 exhibits a yeast metacaspase proteostasis function that protects mitochondria from toxic TDP43 aggregates

Caspase 3 exhibits a yeast metacaspase proteostasis function that protects mitochondria from toxic TDP43 aggregates

Caspase 3 activation is a hallmark of cell death and there is a strong correlation between elevated protease activity and evolving pathology in neurodegenerative disease, such as amyotrophic lateral sclerosis (ALS). At the cellular level, ALS is characterized by protein aggregates and inclusions, co...

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Bibliographic Details
Main Authors: Steve Brunette, Anupam Sharma, Ryan Bell, Lawrence Puente, Lynn A Megeney
Format: Article
Language:English
Published: Shared Science Publishers OG 2023-07-01
Series:Microbial Cell
Subjects:
caspase
metacaspase
yeast
tdp43
proteostasis
protein aggregation
Online Access:http://microbialcell.com/researcharticles/2023a-brunette-microbial-cell/

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