Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia
TRPV1 as a drug target suffers from side effects of hypothermia. Here, authors engineer a peptide, sRhTx, as a positive allosteric modulator of TRPV1 channel. It potentiates the activity of TRPV1 to reversibly ablate pain-sensing nerve terminals for long-lasting analgesia without changing mice body...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34817-1 |
| _version_ | 1797958549414871040 |
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| author | Heng Zhang Jia-Jia Lin Ya-Kai Xie Xiu-Zu Song Jia-Yi Sun Bei-Lei Zhang Yun-Kun Qi Zhen-Zhong Xu Fan Yang |
| author_facet | Heng Zhang Jia-Jia Lin Ya-Kai Xie Xiu-Zu Song Jia-Yi Sun Bei-Lei Zhang Yun-Kun Qi Zhen-Zhong Xu Fan Yang |
| author_sort | Heng Zhang |
| collection | DOAJ |
| description | TRPV1 as a drug target suffers from side effects of hypothermia. Here, authors engineer a peptide, sRhTx, as a positive allosteric modulator of TRPV1 channel. It potentiates the activity of TRPV1 to reversibly ablate pain-sensing nerve terminals for long-lasting analgesia without changing mice body temperature. |
| first_indexed | 2024-04-11T00:21:43Z |
| format | Article |
| id | doaj.art-4f6d4493ac1f4d9c9aa5df9ee8c2731d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T00:21:43Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4f6d4493ac1f4d9c9aa5df9ee8c2731d2023-01-08T12:15:45ZengNature PortfolioNature Communications2041-17232023-01-0114111210.1038/s41467-022-34817-1Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesiaHeng Zhang0Jia-Jia Lin1Ya-Kai Xie2Xiu-Zu Song3Jia-Yi Sun4Bei-Lei Zhang5Yun-Kun Qi6Zhen-Zhong Xu7Fan Yang8Department of Biophysics, Kidney Disease Center of the First Affiliated Hospital, Zhejiang University School of MedicineLiangzhu Laboratory, Zhejiang University Medical CenterLiangzhu Laboratory, Zhejiang University Medical CenterDepartment of Dermatology, The Third People’s Hospital of HangzhouDepartment of Dermatology, The Third People’s Hospital of HangzhouDepartment of Dermatology, The Third People’s Hospital of HangzhouDepartment of Medicinal Chemistry, School of Pharmacy, Qingdao UniversityLiangzhu Laboratory, Zhejiang University Medical CenterDepartment of Biophysics, Kidney Disease Center of the First Affiliated Hospital, Zhejiang University School of MedicineTRPV1 as a drug target suffers from side effects of hypothermia. Here, authors engineer a peptide, sRhTx, as a positive allosteric modulator of TRPV1 channel. It potentiates the activity of TRPV1 to reversibly ablate pain-sensing nerve terminals for long-lasting analgesia without changing mice body temperature.https://doi.org/10.1038/s41467-022-34817-1 |
| spellingShingle | Heng Zhang Jia-Jia Lin Ya-Kai Xie Xiu-Zu Song Jia-Yi Sun Bei-Lei Zhang Yun-Kun Qi Zhen-Zhong Xu Fan Yang Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia Nature Communications |
| title | Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia |
| title_full | Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia |
| title_fullStr | Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia |
| title_full_unstemmed | Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia |
| title_short | Structure-guided peptide engineering of a positive allosteric modulator targeting the outer pore of TRPV1 for long-lasting analgesia |
| title_sort | structure guided peptide engineering of a positive allosteric modulator targeting the outer pore of trpv1 for long lasting analgesia |
| url | https://doi.org/10.1038/s41467-022-34817-1 |
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