Dietary intake of fructose increases purine de novo synthesis: A crucial mechanism for hyperuricemia

Dietary intake of fructose increases purine de novo synthesis: A crucial mechanism for hyperuricemia

BackgroundFructose consumption is a potential risk factor for hyperuricemia because uric acid (UA) is a byproduct of fructose metabolism caused by the rapid consumption of adenosine triphosphate and accumulation of adenosine monophosphate (AMP) and other purine nucleotides. Additionally, a clinical...

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Bibliographic Details
Main Authors:	Pengfei Zhang, Huimin Sun, Xinyu Cheng, Yajing Li, Yanli Zhao, Wuxuan Mei, Xing Wei, Hairong Zhou, Yunbo Du, Changchun Zeng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Series:	Frontiers in Nutrition
Subjects:	purine de novo synthesis fructose hyperuricemia metabolomic analysis RNA-seq analysis
Online Access:	https://www.frontiersin.org/articles/10.3389/fnut.2022.1045805/full

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