Anti-Obesity Effects of Aqueous Extracts of Sunbanghwalmyung-Eum in High-Fat- and High-Cholesterol-Diet-Induced Obese C57BL/6J Mice
Sunbanghwalmyung-eum (SBH) is a traditional herbal medicine that exhibits various pharmacological properties, such as antioxidant, anti-inflammatory, and anticancer activities. In this study, we investigated the systemic anti-obesity effects of an aqueous extract of SBH in the liver, adipose, and mu...
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MDPI AG
2022-07-01
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| author | Hye-Lin Kim You Mee Ahn So Min Lee Chang-Seob Seo Seong-Hwan Park Ok-Sun Bang Jeeyoun Jung |
| author_facet | Hye-Lin Kim You Mee Ahn So Min Lee Chang-Seob Seo Seong-Hwan Park Ok-Sun Bang Jeeyoun Jung |
| author_sort | Hye-Lin Kim |
| collection | DOAJ |
| description | Sunbanghwalmyung-eum (SBH) is a traditional herbal medicine that exhibits various pharmacological properties, such as antioxidant, anti-inflammatory, and anticancer activities. In this study, we investigated the systemic anti-obesity effects of an aqueous extract of SBH in the liver, adipose, and muscle tissue from high-fat and high-cholesterol diet (HFHCD)-induced obese C57BL/6J mice. After 6 weeks of an HFHCD, the mice were continuously fed HFHC with oral administration of SBH (100 mg/kg/day), Sim (simvastatin, 5 mg/kg/day, positive control), or water (HFHC only) for another 6 weeks. Our results showed that SBH attenuated the HFHCD-induced body weight gain and fat accumulation in the liver, and improved plasma lipid levels, such as those of triglycerides (TGs), blood total cholesterol (TC), and low-density lipoprotein (LDL-c). SBH and Sim inhibited the inflammation accompanied by obesity via decreasing inflammatory cytokine interleukin (IL)-1β, tumor necrosis factor α (TNFα), and monocyte chemoattractant protein 1 (MCP1). Moreover, SBH downregulated the expression of protein levels of adipogenic-related factors, including peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα), in the liver, adipose, and muscle tissue. The SBH and Sim treatment also significantly upregulated the phosphorylation of AMP-activated protein kinase α (AMPKα) in the liver and hormone-sensitive lipase (HSL) in the adipose tissue. Overall, the effects of SBH on HFHCD-induced obesity were similar to or more potent than those of simvastatin. These results indicated that SBH has great potential as a therapeutic herbal medicine for obesity. |
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| last_indexed | 2024-03-09T06:05:14Z |
| publishDate | 2022-07-01 |
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| series | Nutrients |
| spelling | doaj.art-4f6e738fb62d4e73ab40ab05da7ea5cc2023-12-03T12:04:39ZengMDPI AGNutrients2072-66432022-07-011414292910.3390/nu14142929Anti-Obesity Effects of Aqueous Extracts of Sunbanghwalmyung-Eum in High-Fat- and High-Cholesterol-Diet-Induced Obese C57BL/6J MiceHye-Lin Kim0You Mee Ahn1So Min Lee2Chang-Seob Seo3Seong-Hwan Park4Ok-Sun Bang5Jeeyoun Jung6KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, KoreaKM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, KoreaKM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, KoreaKM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, KoreaKM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, KoreaKM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, KoreaKM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, KoreaSunbanghwalmyung-eum (SBH) is a traditional herbal medicine that exhibits various pharmacological properties, such as antioxidant, anti-inflammatory, and anticancer activities. In this study, we investigated the systemic anti-obesity effects of an aqueous extract of SBH in the liver, adipose, and muscle tissue from high-fat and high-cholesterol diet (HFHCD)-induced obese C57BL/6J mice. After 6 weeks of an HFHCD, the mice were continuously fed HFHC with oral administration of SBH (100 mg/kg/day), Sim (simvastatin, 5 mg/kg/day, positive control), or water (HFHC only) for another 6 weeks. Our results showed that SBH attenuated the HFHCD-induced body weight gain and fat accumulation in the liver, and improved plasma lipid levels, such as those of triglycerides (TGs), blood total cholesterol (TC), and low-density lipoprotein (LDL-c). SBH and Sim inhibited the inflammation accompanied by obesity via decreasing inflammatory cytokine interleukin (IL)-1β, tumor necrosis factor α (TNFα), and monocyte chemoattractant protein 1 (MCP1). Moreover, SBH downregulated the expression of protein levels of adipogenic-related factors, including peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα), in the liver, adipose, and muscle tissue. The SBH and Sim treatment also significantly upregulated the phosphorylation of AMP-activated protein kinase α (AMPKα) in the liver and hormone-sensitive lipase (HSL) in the adipose tissue. Overall, the effects of SBH on HFHCD-induced obesity were similar to or more potent than those of simvastatin. These results indicated that SBH has great potential as a therapeutic herbal medicine for obesity.https://www.mdpi.com/2072-6643/14/14/2929Sunbanghwalmyung-eumhigh-fat high-cholesterol dietobesityC57BL/6J mice |
| spellingShingle | Hye-Lin Kim You Mee Ahn So Min Lee Chang-Seob Seo Seong-Hwan Park Ok-Sun Bang Jeeyoun Jung Anti-Obesity Effects of Aqueous Extracts of Sunbanghwalmyung-Eum in High-Fat- and High-Cholesterol-Diet-Induced Obese C57BL/6J Mice Nutrients Sunbanghwalmyung-eum high-fat high-cholesterol diet obesity C57BL/6J mice |
| title | Anti-Obesity Effects of Aqueous Extracts of Sunbanghwalmyung-Eum in High-Fat- and High-Cholesterol-Diet-Induced Obese C57BL/6J Mice |
| title_full | Anti-Obesity Effects of Aqueous Extracts of Sunbanghwalmyung-Eum in High-Fat- and High-Cholesterol-Diet-Induced Obese C57BL/6J Mice |
| title_fullStr | Anti-Obesity Effects of Aqueous Extracts of Sunbanghwalmyung-Eum in High-Fat- and High-Cholesterol-Diet-Induced Obese C57BL/6J Mice |
| title_full_unstemmed | Anti-Obesity Effects of Aqueous Extracts of Sunbanghwalmyung-Eum in High-Fat- and High-Cholesterol-Diet-Induced Obese C57BL/6J Mice |
| title_short | Anti-Obesity Effects of Aqueous Extracts of Sunbanghwalmyung-Eum in High-Fat- and High-Cholesterol-Diet-Induced Obese C57BL/6J Mice |
| title_sort | anti obesity effects of aqueous extracts of sunbanghwalmyung eum in high fat and high cholesterol diet induced obese c57bl 6j mice |
| topic | Sunbanghwalmyung-eum high-fat high-cholesterol diet obesity C57BL/6J mice |
| url | https://www.mdpi.com/2072-6643/14/14/2929 |
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