Henoch-Schönlein purpura in adults: a case series from a multidisciplinary study group
BACKGROUND: Henoch-Schönlein purpura (HSP) is a systemic vasculitis involving small vessels with the deposition of immune complexes containing IgA. It has been extensively studied in children, but in adults, its natural history is much less known. OBJECTIVES: to report a series of patients with HSP...
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| Format: | Article |
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Sociedade Brasileira de Reumatologia
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| Series: | Revista Brasileira de Reumatologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042006000600004&lng=en&tlng=en |
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| author | Boris A. Cruz Ana Lúcia V. Vaz de Melo Mariana P. G. Ubirajara Silva Alberto Kazuo Fuzikawa Zaida J. Cabrera Hélcio Antônio Tavares Filho Felipe Fagioli Carolina Rutkowski Abrahão Salomão Filho Austenir Maciel Coelho Rejane Pinheiro Damasceno |
| author_facet | Boris A. Cruz Ana Lúcia V. Vaz de Melo Mariana P. G. Ubirajara Silva Alberto Kazuo Fuzikawa Zaida J. Cabrera Hélcio Antônio Tavares Filho Felipe Fagioli Carolina Rutkowski Abrahão Salomão Filho Austenir Maciel Coelho Rejane Pinheiro Damasceno |
| author_sort | Boris A. Cruz |
| collection | DOAJ |
| description | BACKGROUND: Henoch-Schönlein purpura (HSP) is a systemic vasculitis involving small vessels with the deposition of immune complexes containing IgA. It has been extensively studied in children, but in adults, its natural history is much less known. OBJECTIVES: to report a series of patients with HSP presenting in their adulthood. PATIENTS AND METHODS: the Minas Gerais Vasculitis Study Group´s Members (MGVSG) were invited to report patients with HSP who appeared in their adulthood. A standardized retrospective chart review was done. RESULTS: eleven patients, two male and nine female, age 39.4 +/- 20.1 yearsold were studied. Nine patients presented purpura, seven presented arthritis, four patients had gastrointestinal involvement and ten patients (91%) presented glomerulonephritis (GN). Eight patients were subjected to renal biopsies. Six of them presented endocapillary proliferative GN and only two of them had minimal mesangial proliferation. In the other three patients, HSP was confirmed by skin biopsies. All patients received steroids, in five of them steroids were combined with other immunosuppressive agents. After a follow-up of 39.0 +/- 64.6 months, four patients (36%) presented impairment of renal function, but only one (9%) developed end stage renal disease and was successfully appeared to renal transplantation. At the end of follow-up, seven patients (64%) are in complete remission and four in partial remission. CONCLUSION: in adulthood, HSP represents a distinct clinical syndrome with a higher frequency of renal involvement and more severe systemic vasculitis. Nevertheless, the final outcome in this series was as good as reported in children, maybe due to aggressive immunosuppressive therapy. |
| first_indexed | 2024-12-17T12:01:43Z |
| format | Article |
| id | doaj.art-4f71f1d514ef4960b231c62b53566077 |
| institution | Directory Open Access Journal |
| issn | 1809-4570 |
| language | English |
| last_indexed | 2024-12-17T12:01:43Z |
| publisher | Sociedade Brasileira de Reumatologia |
| record_format | Article |
| series | Revista Brasileira de Reumatologia |
| spelling | doaj.art-4f71f1d514ef4960b231c62b535660772022-12-21T21:49:48ZengSociedade Brasileira de ReumatologiaRevista Brasileira de Reumatologia1809-4570466380384S0482-50042006000600004Henoch-Schönlein purpura in adults: a case series from a multidisciplinary study groupBoris A. Cruz0Ana Lúcia V. Vaz de Melo1Mariana P. G. Ubirajara Silva2Alberto Kazuo Fuzikawa3Zaida J. Cabrera4Hélcio Antônio Tavares Filho5Felipe Fagioli6Carolina Rutkowski7Abrahão Salomão Filho8Austenir Maciel Coelho9Rejane Pinheiro Damasceno10Biocor InstitutoBiocor InstitutoBiocor InstitutoBiocor InstitutoBiocor InstitutoBiocor InstitutoInstituto Mineiro de NefrologiaInstituto Mineiro de NefrologiaInstituto Mineiro de NefrologiaHospital Governador Israel PinheiroHospital Governador Israel PinheiroBACKGROUND: Henoch-Schönlein purpura (HSP) is a systemic vasculitis involving small vessels with the deposition of immune complexes containing IgA. It has been extensively studied in children, but in adults, its natural history is much less known. OBJECTIVES: to report a series of patients with HSP presenting in their adulthood. PATIENTS AND METHODS: the Minas Gerais Vasculitis Study Group´s Members (MGVSG) were invited to report patients with HSP who appeared in their adulthood. A standardized retrospective chart review was done. RESULTS: eleven patients, two male and nine female, age 39.4 +/- 20.1 yearsold were studied. Nine patients presented purpura, seven presented arthritis, four patients had gastrointestinal involvement and ten patients (91%) presented glomerulonephritis (GN). Eight patients were subjected to renal biopsies. Six of them presented endocapillary proliferative GN and only two of them had minimal mesangial proliferation. In the other three patients, HSP was confirmed by skin biopsies. All patients received steroids, in five of them steroids were combined with other immunosuppressive agents. After a follow-up of 39.0 +/- 64.6 months, four patients (36%) presented impairment of renal function, but only one (9%) developed end stage renal disease and was successfully appeared to renal transplantation. At the end of follow-up, seven patients (64%) are in complete remission and four in partial remission. CONCLUSION: in adulthood, HSP represents a distinct clinical syndrome with a higher frequency of renal involvement and more severe systemic vasculitis. Nevertheless, the final outcome in this series was as good as reported in children, maybe due to aggressive immunosuppressive therapy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042006000600004&lng=en&tlng=enpúrpura de Henoch-Schönleinvasculite sistêmicaadultos |
| spellingShingle | Boris A. Cruz Ana Lúcia V. Vaz de Melo Mariana P. G. Ubirajara Silva Alberto Kazuo Fuzikawa Zaida J. Cabrera Hélcio Antônio Tavares Filho Felipe Fagioli Carolina Rutkowski Abrahão Salomão Filho Austenir Maciel Coelho Rejane Pinheiro Damasceno Henoch-Schönlein purpura in adults: a case series from a multidisciplinary study group Revista Brasileira de Reumatologia púrpura de Henoch-Schönlein vasculite sistêmica adultos |
| title | Henoch-Schönlein purpura in adults: a case series from a multidisciplinary study group |
| title_full | Henoch-Schönlein purpura in adults: a case series from a multidisciplinary study group |
| title_fullStr | Henoch-Schönlein purpura in adults: a case series from a multidisciplinary study group |
| title_full_unstemmed | Henoch-Schönlein purpura in adults: a case series from a multidisciplinary study group |
| title_short | Henoch-Schönlein purpura in adults: a case series from a multidisciplinary study group |
| title_sort | henoch schonlein purpura in adults a case series from a multidisciplinary study group |
| topic | púrpura de Henoch-Schönlein vasculite sistêmica adultos |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042006000600004&lng=en&tlng=en |
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