Bacterial accumulation in intestinal folds induced by physical and biological factors
Abstract Background The gut microbiota, vital for host health, influences metabolism, immune function, and development. Understanding the dynamic processes of bacterial accumulation within the gut is crucial, as it is closely related to immune responses, antibiotic resistance, and colorectal cancer....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | BMC Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12915-024-01874-5 |
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| author | Jinyou Yang Toma Isaka Kenji Kikuchi Keiko Numayama-Tsuruta Takuji Ishikawa |
| author_facet | Jinyou Yang Toma Isaka Kenji Kikuchi Keiko Numayama-Tsuruta Takuji Ishikawa |
| author_sort | Jinyou Yang |
| collection | DOAJ |
| description | Abstract Background The gut microbiota, vital for host health, influences metabolism, immune function, and development. Understanding the dynamic processes of bacterial accumulation within the gut is crucial, as it is closely related to immune responses, antibiotic resistance, and colorectal cancer. We investigated Escherichia coli behavior and distribution in zebrafish larval intestines, focusing on the gut microenvironment. Results We discovered that E. coli spread was considerably suppressed within the intestinal folds, leading to a strong physical accumulation in the folds. Moreover, a higher concentration of E. coli on the dorsal side than on the ventral side was observed. Our in vitro microfluidic experiments and theoretical analysis revealed that the overall distribution of E. coli in the intestines was established by a combination of physical factor and bacterial taxis. Conclusions Our findings provide valuable insight into how the intestinal microenvironment affects bacterial motility and accumulation, enhancing our understanding of the behavioral and ecological dynamics of the intestinal microbiota. |
| first_indexed | 2024-04-24T12:36:03Z |
| format | Article |
| id | doaj.art-4f7351122d6d47c09c2f11415770b523 |
| institution | Directory Open Access Journal |
| issn | 1741-7007 |
| language | English |
| last_indexed | 2024-04-24T12:36:03Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj.art-4f7351122d6d47c09c2f11415770b5232024-04-07T11:30:55ZengBMCBMC Biology1741-70072024-04-0122111210.1186/s12915-024-01874-5Bacterial accumulation in intestinal folds induced by physical and biological factorsJinyou Yang0Toma Isaka1Kenji Kikuchi2Keiko Numayama-Tsuruta3Takuji Ishikawa4School of Intelligent Medicine, China Medical UniversityDepartment of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku UniversityDepartment of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku UniversityDepartment of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku UniversityDepartment of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku UniversityAbstract Background The gut microbiota, vital for host health, influences metabolism, immune function, and development. Understanding the dynamic processes of bacterial accumulation within the gut is crucial, as it is closely related to immune responses, antibiotic resistance, and colorectal cancer. We investigated Escherichia coli behavior and distribution in zebrafish larval intestines, focusing on the gut microenvironment. Results We discovered that E. coli spread was considerably suppressed within the intestinal folds, leading to a strong physical accumulation in the folds. Moreover, a higher concentration of E. coli on the dorsal side than on the ventral side was observed. Our in vitro microfluidic experiments and theoretical analysis revealed that the overall distribution of E. coli in the intestines was established by a combination of physical factor and bacterial taxis. Conclusions Our findings provide valuable insight into how the intestinal microenvironment affects bacterial motility and accumulation, enhancing our understanding of the behavioral and ecological dynamics of the intestinal microbiota.https://doi.org/10.1186/s12915-024-01874-5Gut microbiotaBacterial accumulationZebrafish intestineEscherichia coliMathematical analysis |
| spellingShingle | Jinyou Yang Toma Isaka Kenji Kikuchi Keiko Numayama-Tsuruta Takuji Ishikawa Bacterial accumulation in intestinal folds induced by physical and biological factors BMC Biology Gut microbiota Bacterial accumulation Zebrafish intestine Escherichia coli Mathematical analysis |
| title | Bacterial accumulation in intestinal folds induced by physical and biological factors |
| title_full | Bacterial accumulation in intestinal folds induced by physical and biological factors |
| title_fullStr | Bacterial accumulation in intestinal folds induced by physical and biological factors |
| title_full_unstemmed | Bacterial accumulation in intestinal folds induced by physical and biological factors |
| title_short | Bacterial accumulation in intestinal folds induced by physical and biological factors |
| title_sort | bacterial accumulation in intestinal folds induced by physical and biological factors |
| topic | Gut microbiota Bacterial accumulation Zebrafish intestine Escherichia coli Mathematical analysis |
| url | https://doi.org/10.1186/s12915-024-01874-5 |
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